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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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<blockquote data-quote="trax123" data-source="post: 277352" data-attributes="member: 46508"><p>My point was basically my guess is the formulary compounding method is simpler and not refined, though this could mean less crystallization - this is why they use so many different binders and solvents, whereas Natesto's manufacturing process may be more labor intensive to dissolve the hormone in castor oil which is why they're able to produce a much 'cleaner' end-product.</p><p></p><p>Thank you Madman for posting all the links to related discussions (you don't need to keep posting them by the way). </p><p></p><p>Jatenzo obviously causes more suppression and has some more classical TRT side fx which the nasal gel does not. So it's a consideration for me personally and perhaps for others having issues with the gel.</p><p></p><p>I will investigate Empower's gel. My physician has also been able to contact Acerus through their representative (apparently it was difficult but they got to them).</p><p></p><p>//Aside</p><p>So I will comment if I hear anything. I'm not expecting much though, my sense is they probably consider this within tolerances since the entire vial - something like 330mg of Testosterone - gets delivered over 10 days. If you graph the variance against an expected mean of 33mg/day (3x dosing daily) you'll see zeroes and some 100mg doses probably but it's probably true that in 5 days you'll probably get about half of it. </p><p></p><p>Given it's already a low dose with a very short half life AND clinical effects with most people average out over time, I suspect they're 1) well aware of the issue and 2) don't care because ultimately the drug is getting delivered. I agree Granger's point that this could actually interfere with the stated HPG axis pulsing that Natesto is meant to preserve, but I'm also thinking the dose is so low it might not matter in - MOST - people b/c the half life is vanishingly fast.</p><p></p><p>Ergo, I would basically consider Natesto safe/ok from a drug standpoint but very low quality from a product standpoint. And I absolutely don't see this getting fixed, esp. given the comments above about dozens of vials all having crystals and all of mine also having crystals.</p></blockquote><p></p>
[QUOTE="trax123, post: 277352, member: 46508"] My point was basically my guess is the formulary compounding method is simpler and not refined, though this could mean less crystallization - this is why they use so many different binders and solvents, whereas Natesto's manufacturing process may be more labor intensive to dissolve the hormone in castor oil which is why they're able to produce a much 'cleaner' end-product. Thank you Madman for posting all the links to related discussions (you don't need to keep posting them by the way). Jatenzo obviously causes more suppression and has some more classical TRT side fx which the nasal gel does not. So it's a consideration for me personally and perhaps for others having issues with the gel. I will investigate Empower's gel. My physician has also been able to contact Acerus through their representative (apparently it was difficult but they got to them). //Aside So I will comment if I hear anything. I'm not expecting much though, my sense is they probably consider this within tolerances since the entire vial - something like 330mg of Testosterone - gets delivered over 10 days. If you graph the variance against an expected mean of 33mg/day (3x dosing daily) you'll see zeroes and some 100mg doses probably but it's probably true that in 5 days you'll probably get about half of it. Given it's already a low dose with a very short half life AND clinical effects with most people average out over time, I suspect they're 1) well aware of the issue and 2) don't care because ultimately the drug is getting delivered. I agree Granger's point that this could actually interfere with the stated HPG axis pulsing that Natesto is meant to preserve, but I'm also thinking the dose is so low it might not matter in - MOST - people b/c the half life is vanishingly fast. Ergo, I would basically consider Natesto safe/ok from a drug standpoint but very low quality from a product standpoint. And I absolutely don't see this getting fixed, esp. given the comments above about dozens of vials all having crystals and all of mine also having crystals. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Natesto: large shards UPDATE- batch is all bad.
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