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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Maximus: Oral TRT+ (native T + enclomiphene + pregnenolone)
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<blockquote data-quote="Cataceous" data-source="post: 277507" data-attributes="member: 38109"><p>Lack of acute toxicity does not imply long-term safety. Once you get north of 50 ng/mL there are negative correlations over time. Causality may not be firmly established, but why push upper limits without good reason? Interestingly, one study shows an inverted U-shaped curve for serum testosterone as a function of vitamin D levels. The peak for testosterone occurs when vitamin D is in the 30s ng/dL.</p><p></p><p></p><p>The "topical guys" usually experience HPTA suppression and elevated DHT to boot. The duration of action appears to be the driving factor in the former. There's no reason to attack esters per se except for marketing purposes. This approach exposes the vulnerability in having enclomiphene in the protocol. It is decidedly non-bioidentical, and the safety of long-term use is not well-established. There are very likely some effects on non-target receptors, with uncertain consequences. These concerns are not enough to stop me from using enclomiphene, but I have to view it as a calculated risk.</p><p></p><p>These quibbles aside, I'm happy to see another option in the TRT marketplace, and you guys should be commended for making it happen.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 277507, member: 38109"] Lack of acute toxicity does not imply long-term safety. Once you get north of 50 ng/mL there are negative correlations over time. Causality may not be firmly established, but why push upper limits without good reason? Interestingly, one study shows an inverted U-shaped curve for serum testosterone as a function of vitamin D levels. The peak for testosterone occurs when vitamin D is in the 30s ng/dL. The "topical guys" usually experience HPTA suppression and elevated DHT to boot. The duration of action appears to be the driving factor in the former. There's no reason to attack esters per se except for marketing purposes. This approach exposes the vulnerability in having enclomiphene in the protocol. It is decidedly non-bioidentical, and the safety of long-term use is not well-established. There are very likely some effects on non-target receptors, with uncertain consequences. These concerns are not enough to stop me from using enclomiphene, but I have to view it as a calculated risk. These quibbles aside, I'm happy to see another option in the TRT marketplace, and you guys should be commended for making it happen. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Maximus: Oral TRT+ (native T + enclomiphene + pregnenolone)
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