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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low dose enclomiphene combined with Low dose TRT
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<blockquote data-quote="aneuman" data-source="post: 258698" data-attributes="member: 43264"><p>Unfortunately I still can't find the original article which I thought I had saved in Zotero, but found this in a previous post I made. It's just the abstract though:</p><p></p><p></p><p></p><p>Here's the link:</p><p></p><p><a href="https://pure.psu.edu/en/publications/regulation-of-human-gonadotropins-viii-suppression-of-serum-lh-an" target="_blank">Regulation of human gonadotropins. VIII. suppression of serum LH and FSH in adult males following exogenous testosterone administration</a></p><p></p><p>I think it makes sense though. You've mentioned in previous occasions that the typical young, healthy male makes between 5-10 mg os testosterone a day. If your provide 5 mg exogenously, you'll be getting close to the natural top, so it means that there's no reason for the HPGA to shut down, as the total level is within its managed range. As exogenous T starts to get cleared from the system, the HPGA takes over and tries to restart natural production.</p><p></p><p>Once you start going over 5 mg per day, you're getting into persistently elevated levels of T that won't clear soon enough before the next injection for the HPGA to intervene, so it starts to shutdown production until it's atrophies.</p><p></p><p>I'm obviously oversimplifying a much more complex process that includes aromatization, SHBG, etc and ignores a potential androgenic feedback loop.</p><p></p><p>Would love to hear your comments in this regard. In the meantime, I'll continue to look for the original article where I saw this, which wasn't this one.</p></blockquote><p></p>
[QUOTE="aneuman, post: 258698, member: 43264"] Unfortunately I still can't find the original article which I thought I had saved in Zotero, but found this in a previous post I made. It's just the abstract though: Here's the link: [URL='https://pure.psu.edu/en/publications/regulation-of-human-gonadotropins-viii-suppression-of-serum-lh-an']Regulation of human gonadotropins. VIII. suppression of serum LH and FSH in adult males following exogenous testosterone administration[/URL] I think it makes sense though. You've mentioned in previous occasions that the typical young, healthy male makes between 5-10 mg os testosterone a day. If your provide 5 mg exogenously, you'll be getting close to the natural top, so it means that there's no reason for the HPGA to shut down, as the total level is within its managed range. As exogenous T starts to get cleared from the system, the HPGA takes over and tries to restart natural production. Once you start going over 5 mg per day, you're getting into persistently elevated levels of T that won't clear soon enough before the next injection for the HPGA to intervene, so it starts to shutdown production until it's atrophies. I'm obviously oversimplifying a much more complex process that includes aromatization, SHBG, etc and ignores a potential androgenic feedback loop. Would love to hear your comments in this regard. In the meantime, I'll continue to look for the original article where I saw this, which wasn't this one. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low dose enclomiphene combined with Low dose TRT
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