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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Large Testosterone Blood Level Variations Found with the Use of Androgel
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<blockquote data-quote="Nelson Vergel" data-source="post: 20465" data-attributes="member: 3"><p>[ATTACH]1478[/ATTACH]<strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Seru</strong><strong>m Testosterone (T) Level Variability in T Gel- Treated Older Hypogonadal Men: Treatment Monitoring Implications</strong></p><p> </p><p> </p><p>Ronald S. Swerdloff et al</p><p></p><p>doi: 10.1210/JC.2015-1542 J Clin Endocrinol Metab<strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Context: </strong>The optimal frequency for on-treatment serum testosterone (T) measurement used for dose adjustment after transdermal T gel application is unknown, especially in older men with thinner skin and slower metabolic clearance.</p><p> </p><p><strong>Objectives: </strong>To determine variability of post-gel application serum T concentrations and assess whether single levels are reflective of average serum T concentrations over 24h (Cavg0 &#8211;24).</p><p><strong>Design: </strong>A double-blinded, placebo-controlled randomized trial.</p><p> </p><p><strong>Setting: </strong>5 academic centers.</p><p> </p><p><strong>Participants: </strong>47 symptomatic men 65 y.o. with average of two morning T concentration <275 ng/dl.</p><p> </p><p><strong>Intervention(s): </strong>Transdermal T or placebo gel was applied for 120 + or - 14 days. Monthly dose adjustments were made if necessary to target serum T between 400/500 to 800 ng/dl.</p><p> </p><p><strong>Main Outcome Measures: </strong>Variability of serum T 2h post-gel application on 2 outpatient visits and at multiple time-points over 24h during the inpatient day.</p><p> </p><p><strong>Results:</strong> On-treatment T levels varied substantially on the two ambulatory days and over 24h during the inpatient day. Ambulatory 2h post-application T levels did not correlate significantly with either 2h post-application serum T or Cavg0 &#8211;24 measured during the inpatient day. Only 22.2% of men receiving T had Cavg0 &#8211;24 within the target range of 500 &#8211; 800ng/dl; 81.5% had Cavg0 &#8211;24 within the broader 300 &#8211;1000ng/dl range.</p><p> </p><p><strong>Conclusion:</strong> Large within-individual variations in serum T after T gel application render ambulatory 2h post-application T level a poor indicator of average serum T on another day. Our data point out the limitations of dose adjustments based on a single post-application serum T measurement.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 20465, member: 3"] [ATTACH=CONFIG]1478[/ATTACH][B] Seru[/B][B]m Testosterone (T) Level Variability in T Gel- Treated Older Hypogonadal Men: Treatment Monitoring Implications[/B] Ronald S. Swerdloff et al doi: 10.1210/JC.2015-1542 J Clin Endocrinol Metab[B] Context: [/B]The optimal frequency for on-treatment serum testosterone (T) measurement used for dose adjustment after transdermal T gel application is unknown, especially in older men with thinner skin and slower metabolic clearance. [B]Objectives: [/B]To determine variability of post-gel application serum T concentrations and assess whether single levels are reflective of average serum T concentrations over 24h (Cavg0 –24). [B]Design: [/B]A double-blinded, placebo-controlled randomized trial. [B]Setting: [/B]5 academic centers. [B]Participants: [/B]47 symptomatic men 65 y.o. with average of two morning T concentration <275 ng/dl. [B]Intervention(s): [/B]Transdermal T or placebo gel was applied for 120 + or - 14 days. Monthly dose adjustments were made if necessary to target serum T between 400/500 to 800 ng/dl. [B]Main Outcome Measures: [/B]Variability of serum T 2h post-gel application on 2 outpatient visits and at multiple time-points over 24h during the inpatient day. [B]Results:[/B] On-treatment T levels varied substantially on the two ambulatory days and over 24h during the inpatient day. Ambulatory 2h post-application T levels did not correlate significantly with either 2h post-application serum T or Cavg0 –24 measured during the inpatient day. Only 22.2% of men receiving T had Cavg0 –24 within the target range of 500 – 800ng/dl; 81.5% had Cavg0 –24 within the broader 300 –1000ng/dl range. [B]Conclusion:[/B] Large within-individual variations in serum T after T gel application render ambulatory 2h post-application T level a poor indicator of average serum T on another day. Our data point out the limitations of dose adjustments based on a single post-application serum T measurement. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Large Testosterone Blood Level Variations Found with the Use of Androgel
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