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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Issues on trt, ED and high DHT
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<blockquote data-quote="madman" data-source="post: 193455" data-attributes="member: 13851"><p>post#26</p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/dht-labs-should-i-worry.18858/page-2#post-150520[/URL]</p><p></p><p><a href="https://academic.oup.com/edrv/article/38/3/220/3788611" target="_blank">Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels</a></p><p></p><p><strong>We are reminded of Horton’s admonition some 25 years ago when he concluded that <u>blood levels of DHT provide only a hint of tissue levels and that DHT should be regarded as a paracrine hormone formed and acting primarily within target tissues (39)</u>.</strong></p><p><strong></strong></p><p><strong>The modest increases observed in serum DHT and in the DHT/T ratio observed after TRT are unlikely to be a cause of clinical concern, particularly when viewed in the context of changes observed in these parameters for currently marketed T replacement products and those under development for which DHT data are available. <u>There is no sound current clinical evidence to indicate that elevated DHT concentrations (either short-lived peaks or sustained supraphysiological levels) are associated with risk beyond that known for androgens (most notably, T), including adverse effects on the prostate</u>.</strong></p></blockquote><p></p>
[QUOTE="madman, post: 193455, member: 13851"] post#26 [URL unfurl="true"]https://www.excelmale.com/forum/threads/dht-labs-should-i-worry.18858/page-2#post-150520[/URL] [URL='https://academic.oup.com/edrv/article/38/3/220/3788611']Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels[/URL] [B]We are reminded of Horton’s admonition some 25 years ago when he concluded that [U]blood levels of DHT provide only a hint of tissue levels and that DHT should be regarded as a paracrine hormone formed and acting primarily within target tissues (39)[/U]. The modest increases observed in serum DHT and in the DHT/T ratio observed after TRT are unlikely to be a cause of clinical concern, particularly when viewed in the context of changes observed in these parameters for currently marketed T replacement products and those under development for which DHT data are available. [U]There is no sound current clinical evidence to indicate that elevated DHT concentrations (either short-lived peaks or sustained supraphysiological levels) are associated with risk beyond that known for androgens (most notably, T), including adverse effects on the prostate[/U].[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Issues on trt, ED and high DHT
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