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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Is HCG necessary for guys with primary hypogonadism?
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<blockquote data-quote="HarryCat" data-source="post: 11051" data-attributes="member: 856"><p>From this study: <a href="http://press.endocrine.org/doi/full/10.1210/jcem.85.12.7045" target="_blank"><strong>Long-Term Pharmacokinetics of Transdermal Testosterone Gel in Hypogonadal Men</strong></a></p><p></p><p><strong>"Suppression of serum gonadotropin levels</strong></p><p>Because of the wide variability in the baseline serum LH and FSH levels, these were expressed as the percent change from baseline in response to T replacement (Fig. 5). The mean percent suppression of serum LH levels was least in the T patch group (between ∼30–40%), intermediate in the T gel 50 group (between ∼55–60%), and most marked in the T gel 100 group (between∼ 80–85%; <em>P</em> < 0.01). The suppression of serum FSH paralleled that of serum LH levels. <strong>In the subjects with primary hypogonadism, mean serum LH and FSH levels were suppressed to within the normal range after both doses of T gel administration,</strong> but remained above the normal range after T patch application. The suppression of serum gonadotropins occurred in all hypogonadal subjects regardless of the classification of hypogonadism."</p><p></p><p>So the guys who were primary and had the highest T levels got their LH and FSH levels into the normal range. It seems to me that adding HCG would put the total stimulation of LH receptors back above what is normal.</p><p></p><p>I guess I just don't know enough but that rubs me the wrong way if we are trying to restore the body to normal physiological levels of hormones with TRT.</p></blockquote><p></p>
[QUOTE="HarryCat, post: 11051, member: 856"] From this study: [URL="http://press.endocrine.org/doi/full/10.1210/jcem.85.12.7045"][B]Long-Term Pharmacokinetics of Transdermal Testosterone Gel in Hypogonadal Men[/B][/URL] [B]"Suppression of serum gonadotropin levels[/B] Because of the wide variability in the baseline serum LH and FSH levels, these were expressed as the percent change from baseline in response to T replacement (Fig. 5). The mean percent suppression of serum LH levels was least in the T patch group (between ∼30–40%), intermediate in the T gel 50 group (between ∼55–60%), and most marked in the T gel 100 group (between∼ 80–85%; [I]P[/I] < 0.01). The suppression of serum FSH paralleled that of serum LH levels. [B]In the subjects with primary hypogonadism, mean serum LH and FSH levels were suppressed to within the normal range after both doses of T gel administration,[/B] but remained above the normal range after T patch application. The suppression of serum gonadotropins occurred in all hypogonadal subjects regardless of the classification of hypogonadism." So the guys who were primary and had the highest T levels got their LH and FSH levels into the normal range. It seems to me that adding HCG would put the total stimulation of LH receptors back above what is normal. I guess I just don't know enough but that rubs me the wrong way if we are trying to restore the body to normal physiological levels of hormones with TRT. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Is HCG necessary for guys with primary hypogonadism?
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