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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
In the search for libid, Started “”“””Addyi”””””
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<blockquote data-quote="madman" data-source="post: 268655" data-attributes="member: 13851"><p><strong><em>*Currently, it is theorized that flibanserin acts as an agonist at the 5HT1A post-synaptic receptor and as an antagonist at the 5HT2A post-synaptic receptor.</em></strong></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/treatments-for-low-sex-drive-in-men.24739/[/URL]</p><p></p><p><strong>*SEROTONIN RECEPTOR MODULATORS</strong></p><p></p><p><em><strong>Flibanserin (Addyi) is a novel therapy for the treatment of female HSDD. After achieving FDA approval in 2015, the drug was marketed for premenopausal women suffering from HSDD of any severity. <u>Currently, it is theorized that flibanserin acts as an agonist at the 5HT1A post-synaptic receptor and as an antagonist at the 5HT2A post-synaptic receptor. Through modulation of these post-synaptic serotonin receptors in the pre-frontal cortex, flibanserin mediates the release of dopamine and norepinephrine, which play an important role in promoting sexual excitation</u>.13 <u>Concurrently, flibanserin also reduces the level of serotonin, which normally reduces sexual interest by inhibiting dopamine release</u>. At present, flibanserin is not approved for the treatment of low libido in men.</strong> While it is theoretically feasible that similar pathophysiology for HSDD exists in men as in women, clinical trial data would be necessary to prove the effectiveness and safety of flibanserin in men before any widespread off-label use can be recommended. <strong>At present, it is prudent for all prescribers of flibanserin to educate patients on potential side effects including risks for hypotension and syncope, and avoiding the concurrent use of cytochrome P450 3A4 (CYP3A4) inhibitors.13</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 268655, member: 13851"] [B][I]*Currently, it is theorized that flibanserin acts as an agonist at the 5HT1A post-synaptic receptor and as an antagonist at the 5HT2A post-synaptic receptor.[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/treatments-for-low-sex-drive-in-men.24739/[/URL] [B]*SEROTONIN RECEPTOR MODULATORS[/B] [I][B]Flibanserin (Addyi) is a novel therapy for the treatment of female HSDD. After achieving FDA approval in 2015, the drug was marketed for premenopausal women suffering from HSDD of any severity. [U]Currently, it is theorized that flibanserin acts as an agonist at the 5HT1A post-synaptic receptor and as an antagonist at the 5HT2A post-synaptic receptor. Through modulation of these post-synaptic serotonin receptors in the pre-frontal cortex, flibanserin mediates the release of dopamine and norepinephrine, which play an important role in promoting sexual excitation[/U].13 [U]Concurrently, flibanserin also reduces the level of serotonin, which normally reduces sexual interest by inhibiting dopamine release[/U]. At present, flibanserin is not approved for the treatment of low libido in men.[/B] While it is theoretically feasible that similar pathophysiology for HSDD exists in men as in women, clinical trial data would be necessary to prove the effectiveness and safety of flibanserin in men before any widespread off-label use can be recommended. [B]At present, it is prudent for all prescribers of flibanserin to educate patients on potential side effects including risks for hypotension and syncope, and avoiding the concurrent use of cytochrome P450 3A4 (CYP3A4) inhibitors.13[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
In the search for libid, Started “”“””Addyi”””””
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