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Hypopituitary, testosterone and estradiol.
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<blockquote data-quote="Nelson Vergel" data-source="post: 6411" data-attributes="member: 3"><p>PMGAMER18 No one deleted your post. Do you have a copy of it?</p><p></p><p>Yes, we have seen the LEF.org article that started it all.</p><p></p><p>As I reviewed <a href="https://www.excelmale.com/forum/threads/1100-Estradiol-and-Anastrozole-%28Arimidex%29-What-Every-Man-Should-Know" target="_blank">here</a>, I am not disputing the importance of keeping estradiol above 10 pg/mL since E2 levels under that value have been associated with low bone density, higher fat mass, higher cardiovascular risks and lower sex drive.</p><p></p><p>There is one study in men with heart disease that linked higher stroke risks with E2 above 35 pg/mL.</p><p></p><p>There is not a single study published that shows lower sex drive or erectile function with levels over 35 pg/mL. None. That does not mean there is no effect but it means that there are no data. Hopefully Lipshultz will shine a light on this when his complete review is published. No need to get defensive about this statement (unless you can show a published reference that I may have missed).</p><p></p><p>Publishing estradiol data without taking into consideration men's corresponding T levels is misleading.</p><p></p><p>I would speculate that higher estradiol in men with low T is detrimental in many aspects. But there is no indication that the same is true for men with high testosterone. I think that is what the studies should be looking at.</p><p></p><p>Should all men on TRT be given anastrozole? I don't think so unless they monitor their E2 via ultrasensitive testing and its range is 15-35 pg/mL</p><p></p><p>By the way, none of the studies referenced by LEF (or me) used the ultrasensitive test.</p><p></p><p>A clinic I consult with will be doing a study comparing the two estradiol tests in men with TT under and above 500 ng/dL. I will keep you informed about it soon.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 6411, member: 3"] PMGAMER18 No one deleted your post. Do you have a copy of it? Yes, we have seen the LEF.org article that started it all. As I reviewed [URL="https://www.excelmale.com/forum/threads/1100-Estradiol-and-Anastrozole-%28Arimidex%29-What-Every-Man-Should-Know"]here[/URL], I am not disputing the importance of keeping estradiol above 10 pg/mL since E2 levels under that value have been associated with low bone density, higher fat mass, higher cardiovascular risks and lower sex drive. There is one study in men with heart disease that linked higher stroke risks with E2 above 35 pg/mL. There is not a single study published that shows lower sex drive or erectile function with levels over 35 pg/mL. None. That does not mean there is no effect but it means that there are no data. Hopefully Lipshultz will shine a light on this when his complete review is published. No need to get defensive about this statement (unless you can show a published reference that I may have missed). Publishing estradiol data without taking into consideration men's corresponding T levels is misleading. I would speculate that higher estradiol in men with low T is detrimental in many aspects. But there is no indication that the same is true for men with high testosterone. I think that is what the studies should be looking at. Should all men on TRT be given anastrozole? I don't think so unless they monitor their E2 via ultrasensitive testing and its range is 15-35 pg/mL By the way, none of the studies referenced by LEF (or me) used the ultrasensitive test. A clinic I consult with will be doing a study comparing the two estradiol tests in men with TT under and above 500 ng/dL. I will keep you informed about it soon. [/QUOTE]
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Hypopituitary, testosterone and estradiol.
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