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Hypopituitary, testosterone and estradiol.
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<blockquote data-quote="Nelson Vergel" data-source="post: 6395" data-attributes="member: 3"><p>What I am saying is that not a single study has determined what E2 is too high when it comes to sex drive, etc. We know the low side of the range (under 10 pg/mL) may predispose someone to issues. The balance of T versus E2 matters more than the absolute E2 value. Someone with 1000 ng/dL of TT with an E2 of 60 pg/mL (T/E2 of 17) may be be better off than someone with a TT of 550 ng/mL with an E2 of 60 pg/mL (T/E2 of 9). I would not give the first one anastrozole and may give the second one low dose anastrozole. Both have the same E2.</p><p></p><p>There is a reason for T to be the precursor of E. Like all hormones, balance is more important than absolute numbers. </p><p></p><p>We have very limited data on T/E2 ratios but I am pushing for more studies now or re evaluation of old data that can be re-analyzed. I know I will have a lot of push back but hey, new ideas are always rejected.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 6395, member: 3"] What I am saying is that not a single study has determined what E2 is too high when it comes to sex drive, etc. We know the low side of the range (under 10 pg/mL) may predispose someone to issues. The balance of T versus E2 matters more than the absolute E2 value. Someone with 1000 ng/dL of TT with an E2 of 60 pg/mL (T/E2 of 17) may be be better off than someone with a TT of 550 ng/mL with an E2 of 60 pg/mL (T/E2 of 9). I would not give the first one anastrozole and may give the second one low dose anastrozole. Both have the same E2. There is a reason for T to be the precursor of E. Like all hormones, balance is more important than absolute numbers. We have very limited data on T/E2 ratios but I am pushing for more studies now or re evaluation of old data that can be re-analyzed. I know I will have a lot of push back but hey, new ideas are always rejected. [/QUOTE]
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Hypopituitary, testosterone and estradiol.
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