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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
How to Lower Hematocrit Using Grapefruit Seed Extract Naringin
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<blockquote data-quote="Nelson Vergel" data-source="post: 192150" data-attributes="member: 3"><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/curcumin-to-lower-hematocrit.20444/[/URL]</p><p></p><p>The appropriate dose of naringin to lower hematocrit levels is not definitively established, but several studies and sources provide some guidance on effective dosages and their safety.</p><ol> <li data-xf-list-type="ol"><strong>Study on Grapefruit Ingestion</strong>: A study involving the ingestion of grapefruit, which contains naringin, showed that consuming half to one grapefruit per day significantly lowered hematocrit levels in human subjects over a 42-day period. The decrease in hematocrit was statistically significant at the p < 0.01 level, indicating a strong effect.</li> <li data-xf-list-type="ol"><strong>Supplementation Studies</strong>: Naringin supplements are available in various dosages. For instance, a safety and pharmacokinetics study found that doses ranging from 150 mg to 900 mg of naringin were safe for healthy adults, with serum concentrations proportional to the dose administered. This suggests that a dose within this range could be effective and safe.</li> <li data-xf-list-type="ol"><strong>General Recommendations</strong>: Some sources recommend a daily dose of naringin in the range of 40 to 80 mg/kg body weight for various health benefits, including its potential to lower hematocrit levels. This dosage can vary based on individual factors such as age, weight, and overall health.</li> <li data-xf-list-type="ol"><strong>Commercial Supplements</strong>: Commercially available naringin supplements, such as those from Swanson, typically come in 500 mg capsules with a recommended dosage of one capsule twice per day. Another product suggests a daily intake of 600 mg, divided into two doses of 300 mg each.</li> </ol><p>Given these findings, a practical approach would be to start with a lower dose, such as 300 mg twice daily, and adjust based on individual response and under medical supervision. It is crucial to consult with a healthcare provider before starting any new supplement regimen, especially for managing specific health conditions like elevated hematocrit levels.</p><p></p><p></p><p>Citations:</p><p></p><p>[2] <a href="https://pubmed.ncbi.nlm.nih.gov/3243695/" target="_blank">Ingestion of grapefruit lowers elevated hematocrits in human subjects - PubMed</a></p><p>[3] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956701/" target="_blank">Safety and Pharmacokinetics of Naringenin: A Randomized, Controlled, Single Ascending Dose, Clinical Trial</a></p><p>[4] <a href="https://www.scielo.br/j/bjps/a/QCq7fk6CszPnvHNr7RfFWCG/?format=pdf&lang=en" target="_blank">https://www.scielo.br/j/bjps/a/QCq7fk6CszPnvHNr7RfFWCG/?format=pdf&lang=en</a></p><p>[5] <a href="https://www.osmosis.org/answers/hematocrit" target="_blank">https://www.osmosis.org/answers/hematocrit</a></p><p>[6] <a href="https://www.discountedlabs.com/blog/managing-high-hematocrit-levels-induced-by-testosterone-replacement-therapy-a-comprehensive-guide" target="_blank">Comprehensive Guide to Manage High Hematocrit Levels in Testosterone Replacement Therapy</a></p><p>[7] <a href="https://www.medicinenet.com/what_does_a_high_hematocrit_result_mean/article.htm" target="_blank">What Does a High Hematocrit Result Mean?</a></p><p>[8] <a href="https://www.wikihow.com/Lower-Hematocrit-Levels" target="_blank">How to Lower Hematocrit Levels (with Pictures) - wikiHow</a></p><p>[9] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072057/" target="_blank">Erythrocyte Storage Lesion Improvements Mediated by Naringin Screened from Vegetable/Fruit Juice Using Cell Extract and HPLC-MS</a></p><p>[10] <a href="https://www.amazon.com/Swanson-Naringin-500-Milligrams-Capsules/dp/B0017OFS0K" target="_blank">Amazon.com</a></p><p>[11] <a href="https://www.nutriavenue.com/naringin-an-antioxidant-flavonoid-against-cellular-aging/" target="_blank">Naringin: An Antioxidant Flavonoid Against Cellular Aging - nutriavenue.com</a></p><p>[12] <a href="https://pubmed.ncbi.nlm.nih.gov/14613759/" target="_blank">Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects - PubMed</a></p><p>[13] <a href="https://rjptonline.org/HTMLPaper.aspx?Journal=Research+Journal+of+Pharmacy+and+Technology%3BPID%3D2019-12-1-67" target="_blank">https://rjptonline.org/HTMLPaper.aspx?Journal=Research+Journal+of+Pharmacy+and+Technology;PID=2019-12-1-67</a></p><p>[14] <a href="https://us.supersmart.com/en/shop/anti-aging/grapefruit-extract-naringine-supplement-0724" target="_blank">https://us.supersmart.com/en/shop/anti-aging/grapefruit-extract-naringine-supplement-0724</a></p><p>[15] <a href="https://rjptonline.org/HTML_Papers/Research%20Journal%20of%20Pharmacy%20and%20Technology__PID__2019-12-1-67.html" target="_blank">https://rjptonline.org/HTML_Papers/Research Journal of Pharmacy and Technology__PID__2019-12-1-67.html</a></p><p>[16] <a href="https://www.amazon.com/Swanson-Naringin-500-Milligrams-Capsules/product-reviews/B0017OFS0K" target="_blank">https://www.amazon.com/Swanson-Naringin-500-Milligrams-Capsules/product-reviews/B0017OFS0K</a></p><p>[17] <a href="https://www.amazon.com/SUPERSMART-Grapefruit-Vegetarian-antibiotic-Properties/dp/B07JZ3Q4B4" target="_blank">https://www.amazon.com/SUPERSMART-Grapefruit-Vegetarian-antibiotic-Properties/dp/B07JZ3Q4B4</a></p><p>[18] <a href="https://www.researchgate.net/publication/320179736_Hematological_Diseases_and_Therapies_Protective_Effect_of_Flavonoid_Naringin_on_Lambda_cyhalothrin_In-duced_Haematological_and_Hepato-Pathological_Variations_in_Male_Wistar_Rats" target="_blank">https://www.researchgate.net/publication/320179736_Hematological_Diseases_and_Therapies_Protective_Effect_of_Flavonoid_Naringin_on_Lambda_cyhalothrin_In-duced_Haematological_and_Hepato-Pathological_Variations_in_Male_Wistar_Rats</a></p><p>[19] <a href="https://www.sciencedirect.com/science/article/abs/pii/S2210523913000664" target="_blank">https://www.sciencedirect.com/science/article/abs/pii/S2210523913000664</a></p><p>[20] <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/naringin" target="_blank">https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/naringin</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 192150, member: 3"] [URL unfurl="true"]https://www.excelmale.com/forum/threads/curcumin-to-lower-hematocrit.20444/[/URL] The appropriate dose of naringin to lower hematocrit levels is not definitively established, but several studies and sources provide some guidance on effective dosages and their safety. [LIST=1] [*][B]Study on Grapefruit Ingestion[/B]: A study involving the ingestion of grapefruit, which contains naringin, showed that consuming half to one grapefruit per day significantly lowered hematocrit levels in human subjects over a 42-day period. The decrease in hematocrit was statistically significant at the p < 0.01 level, indicating a strong effect. [*][B]Supplementation Studies[/B]: Naringin supplements are available in various dosages. For instance, a safety and pharmacokinetics study found that doses ranging from 150 mg to 900 mg of naringin were safe for healthy adults, with serum concentrations proportional to the dose administered. This suggests that a dose within this range could be effective and safe. [*][B]General Recommendations[/B]: Some sources recommend a daily dose of naringin in the range of 40 to 80 mg/kg body weight for various health benefits, including its potential to lower hematocrit levels. This dosage can vary based on individual factors such as age, weight, and overall health. [*][B]Commercial Supplements[/B]: Commercially available naringin supplements, such as those from Swanson, typically come in 500 mg capsules with a recommended dosage of one capsule twice per day. Another product suggests a daily intake of 600 mg, divided into two doses of 300 mg each. [/LIST] Given these findings, a practical approach would be to start with a lower dose, such as 300 mg twice daily, and adjust based on individual response and under medical supervision. It is crucial to consult with a healthcare provider before starting any new supplement regimen, especially for managing specific health conditions like elevated hematocrit levels. Citations: [2] [URL="https://pubmed.ncbi.nlm.nih.gov/3243695/"]Ingestion of grapefruit lowers elevated hematocrits in human subjects - PubMed[/URL] [3] [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956701/"]Safety and Pharmacokinetics of Naringenin: A Randomized, Controlled, Single Ascending Dose, Clinical Trial[/URL] [4] [URL]https://www.scielo.br/j/bjps/a/QCq7fk6CszPnvHNr7RfFWCG/?format=pdf&lang=en[/URL] [5] [URL]https://www.osmosis.org/answers/hematocrit[/URL] [6] [URL="https://www.discountedlabs.com/blog/managing-high-hematocrit-levels-induced-by-testosterone-replacement-therapy-a-comprehensive-guide"]Comprehensive Guide to Manage High Hematocrit Levels in Testosterone Replacement Therapy[/URL] [7] [URL="https://www.medicinenet.com/what_does_a_high_hematocrit_result_mean/article.htm"]What Does a High Hematocrit Result Mean?[/URL] [8] [URL="https://www.wikihow.com/Lower-Hematocrit-Levels"]How to Lower Hematocrit Levels (with Pictures) - wikiHow[/URL] [9] [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072057/"]Erythrocyte Storage Lesion Improvements Mediated by Naringin Screened from Vegetable/Fruit Juice Using Cell Extract and HPLC-MS[/URL] [10] [URL="https://www.amazon.com/Swanson-Naringin-500-Milligrams-Capsules/dp/B0017OFS0K"]Amazon.com[/URL] [11] [URL="https://www.nutriavenue.com/naringin-an-antioxidant-flavonoid-against-cellular-aging/"]Naringin: An Antioxidant Flavonoid Against Cellular Aging - nutriavenue.com[/URL] [12] [URL="https://pubmed.ncbi.nlm.nih.gov/14613759/"]Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects - PubMed[/URL] [13] [URL]https://rjptonline.org/HTMLPaper.aspx?Journal=Research+Journal+of+Pharmacy+and+Technology%3BPID%3D2019-12-1-67[/URL] [14] [URL]https://us.supersmart.com/en/shop/anti-aging/grapefruit-extract-naringine-supplement-0724[/URL] [15] [URL]https://rjptonline.org/HTML_Papers/Research%20Journal%20of%20Pharmacy%20and%20Technology__PID__2019-12-1-67.html[/URL] [16] [URL]https://www.amazon.com/Swanson-Naringin-500-Milligrams-Capsules/product-reviews/B0017OFS0K[/URL] [17] [URL]https://www.amazon.com/SUPERSMART-Grapefruit-Vegetarian-antibiotic-Properties/dp/B07JZ3Q4B4[/URL] [18] [URL]https://www.researchgate.net/publication/320179736_Hematological_Diseases_and_Therapies_Protective_Effect_of_Flavonoid_Naringin_on_Lambda_cyhalothrin_In-duced_Haematological_and_Hepato-Pathological_Variations_in_Male_Wistar_Rats[/URL] [19] [URL]https://www.sciencedirect.com/science/article/abs/pii/S2210523913000664[/URL] [20] [URL]https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/naringin[/URL] [/QUOTE]
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How to Lower Hematocrit Using Grapefruit Seed Extract Naringin
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