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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How can one increase SHBG when it is too low?
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<blockquote data-quote="Vestpocket" data-source="post: 83254" data-attributes="member: 4848"><p>The problem with SERMs is that the current offerings (tamoxifen/clomiphene) only increase SHBG by up to 30% in studies. For a guy suffering with SHBG between 8-13 nmol/L, we're talking about a difference of a paltry +3 nmol/L. That's essentially irrelevant.</p><p></p><p>The kind of increase we're looking for is 100% — minimum. We want to bring that guy at 13 nmol/L to a more normal 26 nmol/L.</p><p></p><p>Also, if a male isn't seeing SHBG elevation as his E2 increases, he isn't likely to see any movement whatsoever with SHBG just because of a medication that might be a <em>slight </em>estrogen agonist. If estradiol itself didn't work, neither will a SERM.</p><p></p><p>So, we toss SERMs out the window for the sake of this discussion.</p></blockquote><p></p>
[QUOTE="Vestpocket, post: 83254, member: 4848"] The problem with SERMs is that the current offerings (tamoxifen/clomiphene) only increase SHBG by up to 30% in studies. For a guy suffering with SHBG between 8-13 nmol/L, we're talking about a difference of a paltry +3 nmol/L. That's essentially irrelevant. The kind of increase we're looking for is 100% — minimum. We want to bring that guy at 13 nmol/L to a more normal 26 nmol/L. Also, if a male isn't seeing SHBG elevation as his E2 increases, he isn't likely to see any movement whatsoever with SHBG just because of a medication that might be a [I]slight [/I]estrogen agonist. If estradiol itself didn't work, neither will a SERM. So, we toss SERMs out the window for the sake of this discussion. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How can one increase SHBG when it is too low?
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