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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How can one increase SHBG when it is too low?
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<blockquote data-quote="Nelson Vergel" data-source="post: 18230" data-attributes="member: 3"><p>Taking metformin with TRT may increase sex hormone binding globulin (and probably help with fat loss).</p><p></p><p><strong>Effects of short term metformin administration on androgens in normal men.</strong></p><p></p><p>Shegem NS, et al. Saudi Med J. 2002.</p><p><a href="http://www.ncbi.nlm.nih.gov/m/pubmed/12235466/#" target="_blank">Show full citation</a></p><p></p><p><strong>Abstract</strong></p><p></p><p>OBJECTIVE: To study the effect of metformin on androgens in normal men.</p><p>METHODS: A total of 12 healthy males volunteered to participate in the study. A blood sample was obtained from each of them and analyzed for the following: Testosterone (total and free), sex hormone binding globulin dehydroepiandrosterone sulphate, 17-hydroxyprogesterone, luteinizing hormone, and follicle stimulating hormone. In addition, each participant was subjected to a glucose tolerance test and his insulin level was measured. Metformin 850 mg twice daily for 2-weeks was given to each subject after which the above tests were repeated. A paired t-test was used to assess the statistical significance of any observed differences before and after metformin.</p><p>RESULTS: After metformin administration, there was a significant reduction in serum level of total testosterone (p=0.0001), free testosterone (P=0.002), and 17 hydroxyprogesterone (p=0.0001). There was also a significant increase in serum level of sex hormone binding globulin (p=0.009) and dehydroepiandrosterone sulphate (P=0.0008). Serum levels of luteinizing hormone and follicle stimulating hormone showed no significant changes. Similarly, there were no changes in fasting plasma glucose, fasting serum insulin, weight, or blood pressure.</p><p>CONCLUSION: Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. The clinical significance of these findings needs further investigation.</p><p></p><p></p><p><strong><a href="https://www.excelmale.com/forum/showthread.php?4002-where-to-buy-metformin-without-a-script" target="_blank">where to buy metformin without a script</a></strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 18230, member: 3"] Taking metformin with TRT may increase sex hormone binding globulin (and probably help with fat loss). [B]Effects of short term metformin administration on androgens in normal men.[/B] Shegem NS, et al. Saudi Med J. 2002. [URL="http://www.ncbi.nlm.nih.gov/m/pubmed/12235466/#"]Show full citation[/URL] [B]Abstract[/B] OBJECTIVE: To study the effect of metformin on androgens in normal men. METHODS: A total of 12 healthy males volunteered to participate in the study. A blood sample was obtained from each of them and analyzed for the following: Testosterone (total and free), sex hormone binding globulin dehydroepiandrosterone sulphate, 17-hydroxyprogesterone, luteinizing hormone, and follicle stimulating hormone. In addition, each participant was subjected to a glucose tolerance test and his insulin level was measured. Metformin 850 mg twice daily for 2-weeks was given to each subject after which the above tests were repeated. A paired t-test was used to assess the statistical significance of any observed differences before and after metformin. RESULTS: After metformin administration, there was a significant reduction in serum level of total testosterone (p=0.0001), free testosterone (P=0.002), and 17 hydroxyprogesterone (p=0.0001). There was also a significant increase in serum level of sex hormone binding globulin (p=0.009) and dehydroepiandrosterone sulphate (P=0.0008). Serum levels of luteinizing hormone and follicle stimulating hormone showed no significant changes. Similarly, there were no changes in fasting plasma glucose, fasting serum insulin, weight, or blood pressure. CONCLUSION: Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. The clinical significance of these findings needs further investigation. [b][URL="https://www.excelmale.com/forum/showthread.php?4002-where-to-buy-metformin-without-a-script"]where to buy metformin without a script[/URL][/b] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How can one increase SHBG when it is too low?
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