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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
HMG (Human Menopausal Gonadotropin) Vrs HCG (Human Chorionic Gonadotropin) - What’s the difference?
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<blockquote data-quote="Cataceous" data-source="post: 278558" data-attributes="member: 38109"><p>This effect is discussed in <a href="https://pubmed.ncbi.nlm.nih.gov/10087026/" target="_blank">this research</a>. </p><p></p><p style="margin-left: 20px"><em>... the semimechanistic models indicated that the production rate of testosterone increases in [the] presence of rhCG, but the increase does not asymptote to a maximum level but instead <strong>decreases</strong> at higher concentrations of rhCG ...</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>... Last, the relationship of rhCG versus the production rate of testosterone is by means of a rather complex binding model, which is consistent with a two-site binding receptor with an effect proportional to one-site bound concentration.</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>The binding model allows at least two interpretations: the receptor is either deactivated (i.e., stimulation of production rate decreases) or internalized (and stimulation of production rate ends) when more than one molecule binds to it. The study design did not allow separation of a concentration effect at the receptor level or receptor internalization (or a combination of the two), and it is questionable whether an in vivo study aimed at answering this point is feasible. One of the reviewers pointed out a third possibility: a refractory period before the alpha subunit of the G protein recombines with the beta-gamma portion.</em></p> <p style="margin-left: 20px"></p></blockquote><p></p>
[QUOTE="Cataceous, post: 278558, member: 38109"] This effect is discussed in [URL='https://pubmed.ncbi.nlm.nih.gov/10087026/']this research[/URL]. [INDENT][I]... the semimechanistic models indicated that the production rate of testosterone increases in [the] presence of rhCG, but the increase does not asymptote to a maximum level but instead [B]decreases[/B] at higher concentrations of rhCG ...[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]... Last, the relationship of rhCG versus the production rate of testosterone is by means of a rather complex binding model, which is consistent with a two-site binding receptor with an effect proportional to one-site bound concentration.[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]The binding model allows at least two interpretations: the receptor is either deactivated (i.e., stimulation of production rate decreases) or internalized (and stimulation of production rate ends) when more than one molecule binds to it. The study design did not allow separation of a concentration effect at the receptor level or receptor internalization (or a combination of the two), and it is questionable whether an in vivo study aimed at answering this point is feasible. One of the reviewers pointed out a third possibility: a refractory period before the alpha subunit of the G protein recombines with the beta-gamma portion.[/I][/INDENT] [INDENT][I][/I][/INDENT] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
HMG (Human Menopausal Gonadotropin) Vrs HCG (Human Chorionic Gonadotropin) - What’s the difference?
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