ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
HELP - Doubts about TRT
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 279067" data-attributes="member: 38109"><p>A multitude of studies yield the testosterone production figures for healthy young men, as well as serum levels for healthy populations. Obese individuals are excluded from these populations. It's true that there is a skewing of averages in the overall population over time due to factors such as increasing overweight and obesity. If this is creeping into laboratory reference ranges then it's reasonable to rely on earlier research. I frequently refer to <a href="https://journals.sagepub.com/doi/pdf/10.1258/000456306778520115" target="_blank">this study</a>, which finds a normal range for Vermeulen calculated FT in healthy young men of 7.06-22.6 ng/dL.</p><p></p><p></p><p>The differences in total testosterone in response to injected dose are exaggerated by differences in SHBG, as well as differences in protocols and sampling times. The spread should be considerably less dramatic when free testosterone is examined under controlled conditions.</p><p></p><p>You would not be so blasé about taking thyroid hormones at triple the healthy normal production rate. Why should testosterone get a free pass? It's only because the side effects aren't quite as severe and the more-is-better perception persists. There are individuals who can take over 100 mg TC per week without apparent negative effects on health. However, let's not pretend that it's TRT when you're taking in more testosterone than the vast majority of the population could make naturally. If you're going to operate outside of physiological ranges then the burden of proof for safety is on you.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 279067, member: 38109"] A multitude of studies yield the testosterone production figures for healthy young men, as well as serum levels for healthy populations. Obese individuals are excluded from these populations. It's true that there is a skewing of averages in the overall population over time due to factors such as increasing overweight and obesity. If this is creeping into laboratory reference ranges then it's reasonable to rely on earlier research. I frequently refer to [URL='https://journals.sagepub.com/doi/pdf/10.1258/000456306778520115']this study[/URL], which finds a normal range for Vermeulen calculated FT in healthy young men of 7.06-22.6 ng/dL. The differences in total testosterone in response to injected dose are exaggerated by differences in SHBG, as well as differences in protocols and sampling times. The spread should be considerably less dramatic when free testosterone is examined under controlled conditions. You would not be so blasé about taking thyroid hormones at triple the healthy normal production rate. Why should testosterone get a free pass? It's only because the side effects aren't quite as severe and the more-is-better perception persists. There are individuals who can take over 100 mg TC per week without apparent negative effects on health. However, let's not pretend that it's TRT when you're taking in more testosterone than the vast majority of the population could make naturally. If you're going to operate outside of physiological ranges then the burden of proof for safety is on you. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
X (Twitter)
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
HELP - Doubts about TRT
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top