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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
hCG and Vision
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<blockquote data-quote="Nelson Vergel" data-source="post: 9723" data-attributes="member: 3"><p>Women who use HCG to improve fertility use high doses of this peptide (5000-10000 IU per week). Even with these doses, the incidence of retina cancer in children born after women used high dose HCG is low. </p><p></p><p>[h=4]"hCG and Retinoblastoma[/b]We observed that hCG treatment increased, via LHR, the proliferation of Y79 retinoblastoma cell line in vitro. This may suggest a potential risk of gonadotropin use in women infertility treatment on the incidence of this malignant tumor occurrence. Retinoblastoma account for 11% of cancer cases in the first four years of life <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Abramson1" target="_blank">[62]</a> and a link with in vitro fertilization has been pointed out by several authors <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Anteby1" target="_blank">[63]</a>–<a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Marees1" target="_blank">[65]</a>. However, other studies did not established a clear link with this specific type of cancer <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Banerjee1" target="_blank">[66]</a>–<a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-FoixLhlias1" target="_blank">[68]</a> even if the increased risk of pediatric cancers after infertility treatment have been globally demonstrated <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Kallen1" target="_blank">[69]</a>. The discrepancy between the studies may be due to the low incidence of this disease (1 out of 15–20 000 children) leading to only few cases of retinoblastoma after infertility treatment. For instance, in the work of Foix-L’hélias (2012), only 8% of the retinoblastoma cases studied (20 out of 244) occurred in children whom mothers had undergone various infertility treatments <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-FoixLhlias1" target="_blank">[68]</a>. Our finding suggests that future studies on the potential hazard of gonadotropins used for ovarian stimulation should take into account the exact protocol of the hormonal treatment (length, type and concentration of gonadotropins)."</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 9723, member: 3"] Women who use HCG to improve fertility use high doses of this peptide (5000-10000 IU per week). Even with these doses, the incidence of retina cancer in children born after women used high dose HCG is low. [h=4]"hCG and Retinoblastoma[/b]We observed that hCG treatment increased, via LHR, the proliferation of Y79 retinoblastoma cell line in vitro. This may suggest a potential risk of gonadotropin use in women infertility treatment on the incidence of this malignant tumor occurrence. Retinoblastoma account for 11% of cancer cases in the first four years of life [URL="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Abramson1"][62][/URL] and a link with in vitro fertilization has been pointed out by several authors [URL="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Anteby1"][63][/URL]–[URL="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Marees1"][65][/URL]. However, other studies did not established a clear link with this specific type of cancer [URL="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Banerjee1"][66][/URL]–[URL="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-FoixLhlias1"][68][/URL] even if the increased risk of pediatric cancers after infertility treatment have been globally demonstrated [URL="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-Kallen1"][69][/URL]. The discrepancy between the studies may be due to the low incidence of this disease (1 out of 15–20 000 children) leading to only few cases of retinoblastoma after infertility treatment. For instance, in the work of Foix-L’hélias (2012), only 8% of the retinoblastoma cases studied (20 out of 244) occurred in children whom mothers had undergone various infertility treatments [URL="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052567#pone.0052567-FoixLhlias1"][68][/URL]. Our finding suggests that future studies on the potential hazard of gonadotropins used for ovarian stimulation should take into account the exact protocol of the hormonal treatment (length, type and concentration of gonadotropins)." [/QUOTE]
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