ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Got Test results after 3 months 1% T-Gel . . . very rattled!
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 277977" data-attributes="member: 13851"><p><strong><em>*Variable rate of absorption.</em></strong></p><p></p><p><em><strong>*<u>Skin structural differences</u> may be one of the causes of these significant variations in bioavailability of drug</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*As significant day-to-day variability of serum T levels due to <u>absorption or other reasons</u> is likely, especially in older men</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Recent studies in <u>older hypogonadal men have shown that after testosterone gel application there were large fluctuations in serum testosterone concentration both within and between patients</u> [8]. <u>Skin structural differences may be one of the causes of these significant variations in the bioavailability of the drug</u>, which poses challenges in predicting the effectiveness of medication and determining an adequate dose, as well as an appropriate time for testing serum testosterone levels [8, 32].</strong> <strong>Non time-dependent pulses of serum testosterone also occur in relation to exercise and skin temperature. Both factors may be mediated through changes in dermal blood flow.</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<em>Different sites for drug application have been studied with various degrees of success. <strong><u>Scrotal skin is thin and highly vascular hence it leads to better and sustained absorption of testosterone, which made it one of the early targets in the development of transdermal patch preparations</u>. <u>Scrotal application is not used for the gels because of the relatively small area where the gel can be applied</u>.</strong> <strong>Application on the axillary region may enhance absorption and may cause less skin transfer, and has been shown to be beneficial to patients who failed other transdermal preparations in a single study [34].</strong> However, because the skin is sensitive in the area, skin irritation, edema, and erythema have been observed as in other transdermal preparations [35]. <strong>On the other hand, even though the application of 1.62 % testosterone gel on abdominal skin led to 30–40 % lower availability than on the upper arms and shoulders, application on all of these sites resulted in eugonadal testosterone levels [36]. <u>While a selection of an application site may not be an issue for most patients, those failing to achieve sufficient systemic levels may benefit from a change of site</u>.</strong></em></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<em><strong>Additionally, some gels include emollients that prevent skin drying and ensure better testosterone absorption. </strong><u>There are data to suggest that this may help achieve better bioavailability and higher serum concentrations</u> [37]</em></strong></em></p><p><em><strong><em></em></strong></em></p><p><em><strong><em></em></strong></em></p><p><em><strong><em>*For monitoring of testosterone concentrations after transdermal gel application,<u> blood for dose adjustment should be drawn 2–8 h after the application following manufacturers recommendations</u>. <u>As significant day-to-day variability of serum T levels due to absorption or other reasons is likely, especially in older men</u> [9], major dosing decisions should not be made based on a single measurement.</em></strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 277977, member: 13851"] [B][I]*Variable rate of absorption.[/I][/B] [I][B]*[U]Skin structural differences[/U] may be one of the causes of these significant variations in bioavailability of drug *As significant day-to-day variability of serum T levels due to [U]absorption or other reasons[/U] is likely, especially in older men *Recent studies in [U]older hypogonadal men have shown that after testosterone gel application there were large fluctuations in serum testosterone concentration both within and between patients[/U] [8]. [U]Skin structural differences may be one of the causes of these significant variations in the bioavailability of the drug[/U], which poses challenges in predicting the effectiveness of medication and determining an adequate dose, as well as an appropriate time for testing serum testosterone levels [8, 32].[/B] [B]Non time-dependent pulses of serum testosterone also occur in relation to exercise and skin temperature. Both factors may be mediated through changes in dermal blood flow. *[I]Different sites for drug application have been studied with various degrees of success. [B][U]Scrotal skin is thin and highly vascular hence it leads to better and sustained absorption of testosterone, which made it one of the early targets in the development of transdermal patch preparations[/U]. [U]Scrotal application is not used for the gels because of the relatively small area where the gel can be applied[/U].[/B] [B]Application on the axillary region may enhance absorption and may cause less skin transfer, and has been shown to be beneficial to patients who failed other transdermal preparations in a single study [34].[/B] However, because the skin is sensitive in the area, skin irritation, edema, and erythema have been observed as in other transdermal preparations [35]. [B]On the other hand, even though the application of 1.62 % testosterone gel on abdominal skin led to 30–40 % lower availability than on the upper arms and shoulders, application on all of these sites resulted in eugonadal testosterone levels [36]. [U]While a selection of an application site may not be an issue for most patients, those failing to achieve sufficient systemic levels may benefit from a change of site[/U].[/B][/I] *[I][B]Additionally, some gels include emollients that prevent skin drying and ensure better testosterone absorption. [/B][U]There are data to suggest that this may help achieve better bioavailability and higher serum concentrations[/U] [37] *For monitoring of testosterone concentrations after transdermal gel application,[U] blood for dose adjustment should be drawn 2–8 h after the application following manufacturers recommendations[/U]. [U]As significant day-to-day variability of serum T levels due to absorption or other reasons is likely, especially in older men[/U] [9], major dosing decisions should not be made based on a single measurement.[/I][/B][/I] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Got Test results after 3 months 1% T-Gel . . . very rattled!
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top