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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
e2 vs e2 ultra sensitive
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<blockquote data-quote="Gene Devine" data-source="post: 16726" data-attributes="member: 4"><p>This is an excerpt from Dr. John Crisler's new book; Testosterone; A Receipt for Success re the Sensitive E2 assay.</p><p></p><p>Good idea to buy the book and learn!</p><p></p><p>This is VERY important: unless you specify a “sensitive” (or “ultrasensitive”, or “enhanced”) assay for your male patients, the lab will default to the standard estradiol test, which is designed for women. The standard laboratory methodology is invalid for adult males. In fact, if you do that by what is called immunoassay technique with Quest Diagnostics, a paragraph will appear below the results, directing you to run the correct test next time.</p><p></p><p></p><p>The reason for this discrepancy is the bottom of “normal range” for a woman is the top of “normal range” for a man. Without getting too technical, laboratory science is based on what is called the bell curve, which uses statistical analysis of a given patient population to figure out what “normal” is. Specifically, it is meant to cover 95% of the population. Aside from the issues with the concept of “normal” range (explored more fully elsewhere in this paper) the bell curve, for this test, sits well within the “normal” range for females. </p><p></p><p>Therefore the hormonal concentration range appropriate to adult males falls on a very flat slope out on the edge of the bell curve. You want your result to land on a steep slope--positive or negative--of the bell curve. Laboratory testing is best when small changes in concentrations result in large changes in the reported result.</p></blockquote><p></p>
[QUOTE="Gene Devine, post: 16726, member: 4"] This is an excerpt from Dr. John Crisler's new book; Testosterone; A Receipt for Success re the Sensitive E2 assay. Good idea to buy the book and learn! This is VERY important: unless you specify a “sensitive” (or “ultrasensitive”, or “enhanced”) assay for your male patients, the lab will default to the standard estradiol test, which is designed for women. The standard laboratory methodology is invalid for adult males. In fact, if you do that by what is called immunoassay technique with Quest Diagnostics, a paragraph will appear below the results, directing you to run the correct test next time. The reason for this discrepancy is the bottom of “normal range” for a woman is the top of “normal range” for a man. Without getting too technical, laboratory science is based on what is called the bell curve, which uses statistical analysis of a given patient population to figure out what “normal” is. Specifically, it is meant to cover 95% of the population. Aside from the issues with the concept of “normal” range (explored more fully elsewhere in this paper) the bell curve, for this test, sits well within the “normal” range for females. Therefore the hormonal concentration range appropriate to adult males falls on a very flat slope out on the edge of the bell curve. You want your result to land on a steep slope--positive or negative--of the bell curve. Laboratory testing is best when small changes in concentrations result in large changes in the reported result. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
e2 vs e2 ultra sensitive
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