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<blockquote data-quote="Anonymon" data-source="post: 231774" data-attributes="member: 42608"><p>Finasteride blocks 5AR type 2, not both 1 and 2. Here are the full list of conversions:</p><p></p><p>Cholestenone → 5α-Cholestanone</p><p>Progesterone → 5α-Dihydroprogesterone</p><p>3α-Dihydroprogesterone → Allopregnanolone</p><p>3β-Dihydroprogesterone → Isopregnanolone</p><p>Deoxycorticosterone → 5α-Dihydrodeoxycorticosterone</p><p>Corticosterone → 5α-Dihydrocorticosterone</p><p>Cortisol → 5α-Dihydrocortisol</p><p>Aldosterone → 5α-Dihydroaldosterone</p><p>Androstenedione → 5α-Androstanedione</p><p>Testosterone → 5α-Dihydrotestosterone</p><p>Nandrolone → 5α-Dihydronandrolone</p><p></p><p>I’m not entirely sure how type would affect what converts what, but there appears to be at least some substantial overlap because dutasteride inhibits type 1 and type 2 and reduces DHT even further than finasteride despite finasteride still hitting it pretty hard. Could also be dose related I suppose, but that’s less likely. Plenty of guys like me with PFS have documented issues with allopregnenolone and cortisol and testosterone, and things that overlap with that, such as thyroid levels. If you mess up any one of those hormonal axises you can easily throw the others off.</p><p></p><p>5AR seems self perpetuating, so if someone starts on test to a super high level and uses it, they seem to be a lot more protected from it, like bodybuilders. Maybe not all but many. </p><p></p><p>If any of the above get thrown off, you can also cause other issues to form that are further complications of it, and things can cascade from there, as it did with me. It’s not something to be taken lightly. The old wisdom used to be that if it messed something up it’d be your testosterone, so you’d just hop on gear and be fine. That’s decidedly not true and in many people makes things worse. </p><p></p><p>In general, 5AR’s amazing and if I could do anything it’d be to increase it.</p></blockquote><p></p>
[QUOTE="Anonymon, post: 231774, member: 42608"] Finasteride blocks 5AR type 2, not both 1 and 2. Here are the full list of conversions: Cholestenone → 5α-Cholestanone Progesterone → 5α-Dihydroprogesterone 3α-Dihydroprogesterone → Allopregnanolone 3β-Dihydroprogesterone → Isopregnanolone Deoxycorticosterone → 5α-Dihydrodeoxycorticosterone Corticosterone → 5α-Dihydrocorticosterone Cortisol → 5α-Dihydrocortisol Aldosterone → 5α-Dihydroaldosterone Androstenedione → 5α-Androstanedione Testosterone → 5α-Dihydrotestosterone Nandrolone → 5α-Dihydronandrolone I’m not entirely sure how type would affect what converts what, but there appears to be at least some substantial overlap because dutasteride inhibits type 1 and type 2 and reduces DHT even further than finasteride despite finasteride still hitting it pretty hard. Could also be dose related I suppose, but that’s less likely. Plenty of guys like me with PFS have documented issues with allopregnenolone and cortisol and testosterone, and things that overlap with that, such as thyroid levels. If you mess up any one of those hormonal axises you can easily throw the others off. 5AR seems self perpetuating, so if someone starts on test to a super high level and uses it, they seem to be a lot more protected from it, like bodybuilders. Maybe not all but many. If any of the above get thrown off, you can also cause other issues to form that are further complications of it, and things can cascade from there, as it did with me. It’s not something to be taken lightly. The old wisdom used to be that if it messed something up it’d be your testosterone, so you’d just hop on gear and be fine. That’s decidedly not true and in many people makes things worse. In general, 5AR’s amazing and if I could do anything it’d be to increase it. [/QUOTE]
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