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Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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<blockquote data-quote="Nelson Vergel" data-source="post: 16915" data-attributes="member: 3"><p><strong>EFFECT OF TESTOSTERONE REPLACEMENT THERAPY ON INCIDENCE OF DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM </strong></p><p><strong></strong> </p><p>Rishi Sharma; Olurinde Oni; Rajat Barua; Mukut Sharma; Ram Sharma; Guoqing Chen; Kamal Gupta</p><p></p><p>J Am Coll Cardiol. 2015;65(10_S):. doi:10.1016/S0735-1097(15)61422-X</p><p></p><p></p><p>Background:</p><p></p><p>Testosterone Replacement Therapy (TRT) prescriptions have increased 400% in the last decade. Concern over the risk of deep venous thrombosis (DVT) and pulmonary embolism (PE) with TRT has led the FDA to issue an alert. The association of TRT with DVT/PE is not clearly understood. The aim of this study was to examine the incidence of DVT/PE following TRT using a large patient database.</p><p></p><p>Methods:</p><p></p><p></p><p>We used Veteran Affairs Informatics and Computing Infrastructure (VINCI) database, to select a cohort of US veterans who were found to have low serum total testosterone levels (sTT) during 1999 - 2012. We compared the risk of incidence of DVT/PE between those who received TRT resulting in normalization of sTT and those who did not receive TRT. Those with prior history of DVT/PE were excluded. The risk adjusted and unadjusted approaches were used to adjust for the potential confounding effects. We also assessed various independent risk factors and their association with DVT/PE risk.</p><p></p><p>Results:</p><p></p><p>Of a total of 54000 patients with low sTT, 41121 received TRT (mean age = 63.9 yrs ± 11.4, mean follow-up = 5.9 yrs ± 3.2) while 12879 did not (mean age = 67.0 yrs ± 13.4, mean follow-up = 4.4 yrs ± 3.0). New cases of DVT/PE were identified in 259 patients in the TRT group vs. 59 in the non-TRT group. Table shows that there was no statistically significant increase in the incidence of DVT/PE following TRT therapy.</p><p></p><p></p><p> </p><p>Conclusion:</p><p></p><p>In patients with low sTT , TRT did not result in a statistically significant increase in incidence of DVT/PE.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 16915, member: 3"] [B]EFFECT OF TESTOSTERONE REPLACEMENT THERAPY ON INCIDENCE OF DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM [/B] Rishi Sharma; Olurinde Oni; Rajat Barua; Mukut Sharma; Ram Sharma; Guoqing Chen; Kamal Gupta J Am Coll Cardiol. 2015;65(10_S):. doi:10.1016/S0735-1097(15)61422-X Background: Testosterone Replacement Therapy (TRT) prescriptions have increased 400% in the last decade. Concern over the risk of deep venous thrombosis (DVT) and pulmonary embolism (PE) with TRT has led the FDA to issue an alert. The association of TRT with DVT/PE is not clearly understood. The aim of this study was to examine the incidence of DVT/PE following TRT using a large patient database. Methods: We used Veteran Affairs Informatics and Computing Infrastructure (VINCI) database, to select a cohort of US veterans who were found to have low serum total testosterone levels (sTT) during 1999 - 2012. We compared the risk of incidence of DVT/PE between those who received TRT resulting in normalization of sTT and those who did not receive TRT. Those with prior history of DVT/PE were excluded. The risk adjusted and unadjusted approaches were used to adjust for the potential confounding effects. We also assessed various independent risk factors and their association with DVT/PE risk. Results: Of a total of 54000 patients with low sTT, 41121 received TRT (mean age = 63.9 yrs ± 11.4, mean follow-up = 5.9 yrs ± 3.2) while 12879 did not (mean age = 67.0 yrs ± 13.4, mean follow-up = 4.4 yrs ± 3.0). New cases of DVT/PE were identified in 259 patients in the TRT group vs. 59 in the non-TRT group. Table shows that there was no statistically significant increase in the incidence of DVT/PE following TRT therapy. Conclusion: In patients with low sTT , TRT did not result in a statistically significant increase in incidence of DVT/PE. [/QUOTE]
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Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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