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Mental Health
Bioavailable testosterone is associated with symptoms of depression in adult men
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<blockquote data-quote="Seagal" data-source="post: 276389" data-attributes="member: 45300"><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557700/[/URL]</p><p></p><p>Results</p><p>Mean testosterone, sex hormone-binding globulin, and luteinizing hormone levels were significantly higher in the depressive symptom group than in the non-depressed group. The mean calculated free serum testosterone level and free testosterone index (FTI) were significantly lower in the depressive symptom group than in the non-depressed group. Additionally, the mean FTI was significantly negatively correlated with the Beck Depression Inventory scale score in the multiple linear regression model (95% confidence interval: −3.274 to −0.406).</p><p></p><p>Calculated free serum testosterone (cFT) was quantified using Vermeulen’s formula and calculated as follows: free testosterone (nmol/L) = −a + √b)/c/10−9, with a=SHBG (nmol/L)−total testosterone (nmol/L) + 23.43, b = a2 + (4 × 23.43 × testosterone [nmol/L]), and c = 2 × 23.43 × 109.32 The free testosterone index (FTI) was defined as testosterone (nmol/L)/SHBG (nmol/L) and the testosterone secreting index (TSI) as testosterone (nmol/L)/LH (IU/L).</p></blockquote><p></p>
[QUOTE="Seagal, post: 276389, member: 45300"] [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557700/[/URL] Results Mean testosterone, sex hormone-binding globulin, and luteinizing hormone levels were significantly higher in the depressive symptom group than in the non-depressed group. The mean calculated free serum testosterone level and free testosterone index (FTI) were significantly lower in the depressive symptom group than in the non-depressed group. Additionally, the mean FTI was significantly negatively correlated with the Beck Depression Inventory scale score in the multiple linear regression model (95% confidence interval: −3.274 to −0.406). Calculated free serum testosterone (cFT) was quantified using Vermeulen’s formula and calculated as follows: free testosterone (nmol/L) = −a + √b)/c/10−9, with a=SHBG (nmol/L)−total testosterone (nmol/L) + 23.43, b = a2 + (4 × 23.43 × testosterone [nmol/L]), and c = 2 × 23.43 × 109.32 The free testosterone index (FTI) was defined as testosterone (nmol/L)/SHBG (nmol/L) and the testosterone secreting index (TSI) as testosterone (nmol/L)/LH (IU/L). [/QUOTE]
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Mental Health
Bioavailable testosterone is associated with symptoms of depression in adult men
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