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General Health & Fitness
Nutrition and Supplements
Association Between Vitamin D and Testosterone Blood Levels
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<blockquote data-quote="Nelson Vergel" data-source="post: 28164" data-attributes="member: 3"><p><strong>Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men. </strong></p><p></p><p>Highlights</p><p></p><p>· Vitamin D might influence sex hormone and gonadotropin levels.</p><p>· We studied relationships between 25(OH)D, gene polymorphisms and sex hormone levels.</p><p>· Lower Vitamin D status is associated with lower testosterone levels.</p><p>· There was no association between gene polymorphisms and sex hormone levels.</p><p></p><p>Rafiq R, van Schoor NM, Sohl E, et al. J Steroid Biochem Mol Biol. <a href="http://www.sciencedirect.com/science/article/pii/S0960076015301394" target="_blank">http://www.sciencedirect.com/science/article/pii/S0960076015301394</a> </p><p></p><p>OBJECTIVE: Evidence regarding relationships of serum 25-hydroxyvitamin D (25(OH)D) with sex hormones and gonadotropin concentrations remains inconsistent. Polymorphisms in vitamin D-related genes may underly these relationships. Our aim was to examine the relationship of vitamin D status and polymorphisms in vitamin D-related genes with sex hormone and gonadotropin levels.</p><p></p><p>DESIGN AND MEASUREMENTS: We analysed data from the Longitudinal Aging Study Amsterdam, an ongoing population-based cohort study of older Dutch individuals (65-89 years).</p><p></p><p>We included data of men with measurements of serum 25-hydroxyvitamin D (25(OH)D) (n=643) and determination of vitamin D-related gene polymorphisms (n=459). 25(OH)D concentrations were classified into four categories: <25, 25-50, 50-75 and >75 nmol/L.</p><p></p><p>Outcome measures were total testosterone, calculated bioavailable and free fraction testosterone, SHBG, estradiol, LH and FSH concentrations. Hypogonadism was defined as a total testosterone level <8.0 nmol/L.</p><p></p><p>RESULTS: Serum 25(OH)D was positively associated with total and bioavailable testosterone levels.</p><p></p><p>After adjustments for confounders, men with serum 25(OH)D less than 25 (n=56), 25-50 (n=199) and 50-75 nmol/L (n=240) had lower total testosterone levels compared to men with serum 25(OH)D higher than 75 nmol/L (n=148) (Beta(95% confidence interval): -2.1(-3.7 to -0.4 nmol/L), -0.8(-1.9 to 0.4 nmol/L) and -1.4 (-2.4 to -0.3 nmol/L), respectively).</p><p></p><p>For bioavailable testosterone the association was significant only for men with serum 25(OH)D less than 25 nmol/L (-0.8 (-1.4 to -0.1 nmol/L)) compared to men with serum 25(OH)D >75 nmol/L.</p><p></p><p>Serum 25(OH)D was not related to SHBG, estradiol or gonadotropin levels.</p><p></p><p>Hypogonadism (n=29) was not associated with lower serum 25(OH)D.</p><p></p><p>No significant differences were found in hormone levels between the different genotypes of the vitamin D-related gene polymorphisms. Also, the polymorphisms did not modify the relationships of serum 25(OH)D with sex hormones or gonadotropins.</p><p></p><p>CONCLUSION: Vitamin D status is positively associated with testosterone levels. No association was found between vitamin D-related gene polymorphisms and hormone levels.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 28164, member: 3"] [B]Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men. [/B] Highlights · Vitamin D might influence sex hormone and gonadotropin levels. · We studied relationships between 25(OH)D, gene polymorphisms and sex hormone levels. · Lower Vitamin D status is associated with lower testosterone levels. · There was no association between gene polymorphisms and sex hormone levels. Rafiq R, van Schoor NM, Sohl E, et al. J Steroid Biochem Mol Biol. [url]http://www.sciencedirect.com/science/article/pii/S0960076015301394[/url] OBJECTIVE: Evidence regarding relationships of serum 25-hydroxyvitamin D (25(OH)D) with sex hormones and gonadotropin concentrations remains inconsistent. Polymorphisms in vitamin D-related genes may underly these relationships. Our aim was to examine the relationship of vitamin D status and polymorphisms in vitamin D-related genes with sex hormone and gonadotropin levels. DESIGN AND MEASUREMENTS: We analysed data from the Longitudinal Aging Study Amsterdam, an ongoing population-based cohort study of older Dutch individuals (65-89 years). We included data of men with measurements of serum 25-hydroxyvitamin D (25(OH)D) (n=643) and determination of vitamin D-related gene polymorphisms (n=459). 25(OH)D concentrations were classified into four categories: <25, 25-50, 50-75 and >75 nmol/L. Outcome measures were total testosterone, calculated bioavailable and free fraction testosterone, SHBG, estradiol, LH and FSH concentrations. Hypogonadism was defined as a total testosterone level <8.0 nmol/L. RESULTS: Serum 25(OH)D was positively associated with total and bioavailable testosterone levels. After adjustments for confounders, men with serum 25(OH)D less than 25 (n=56), 25-50 (n=199) and 50-75 nmol/L (n=240) had lower total testosterone levels compared to men with serum 25(OH)D higher than 75 nmol/L (n=148) (Beta(95% confidence interval): -2.1(-3.7 to -0.4 nmol/L), -0.8(-1.9 to 0.4 nmol/L) and -1.4 (-2.4 to -0.3 nmol/L), respectively). For bioavailable testosterone the association was significant only for men with serum 25(OH)D less than 25 nmol/L (-0.8 (-1.4 to -0.1 nmol/L)) compared to men with serum 25(OH)D >75 nmol/L. Serum 25(OH)D was not related to SHBG, estradiol or gonadotropin levels. Hypogonadism (n=29) was not associated with lower serum 25(OH)D. No significant differences were found in hormone levels between the different genotypes of the vitamin D-related gene polymorphisms. Also, the polymorphisms did not modify the relationships of serum 25(OH)D with sex hormones or gonadotropins. CONCLUSION: Vitamin D status is positively associated with testosterone levels. No association was found between vitamin D-related gene polymorphisms and hormone levels. [/QUOTE]
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Association Between Vitamin D and Testosterone Blood Levels
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