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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 39981" data-attributes="member: 12687">You are ALL correct, just in different ways...GeauxBears and Gene are correct in the most practical sense, but before I get to that - ERO, you are correct that an AI will not cause an increase in T for a man on TRT via HPTA stimulation, simply as you stated because the HPTA is suppressed anyways. HOWEVER, GeauxBears and Gene are correct that the AI will still &quot;PRESERVE&quot; some testosterone from being &quot;lost&quot; in the conversion to estradiol. In other words, it will prevent some of the T from being &quot;chopped off the top&quot; so to speak, and therefore may result in a mild-moderate increase in Total T (we must keep in mind that the concentrations of E in the male system are so much smaller than the concentrations of T that this is usually a minor impact). As another layer of complexity, and sometimes a stronger effect, lower E with an AI *usually* translates to lower SHBG, which may then translate to higher free T...obviously many other factors, but you can see that angle.</blockquote>

[QUOTE="Dr Justin Saya MD, post: 39981, member: 12687"] You are ALL correct, just in different ways...GeauxBears and Gene are correct in the most practical sense, but before I get to that - ERO, you are correct that an AI will not cause an increase in T for a man on TRT via HPTA stimulation, simply as you stated because the HPTA is suppressed anyways. HOWEVER, GeauxBears and Gene are correct that the AI will still "PRESERVE" some testosterone from being "lost" in the conversion to estradiol. In other words, it will prevent some of the T from being "chopped off the top" so to speak, and therefore may result in a mild-moderate increase in Total T (we must keep in mind that the concentrations of E in the male system are so much smaller than the concentrations of T that this is usually a minor impact). As another layer of complexity, and sometimes a stronger effect, lower E with an AI *usually* translates to lower SHBG, which may then translate to higher free T...obviously many other factors, but you can see that angle. [/QUOTE]

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