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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
advia centaur estradiol e2
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<blockquote data-quote="Nelson Vergel" data-source="post: 10472" data-attributes="member: 3"><p>I had never heard of it but it seems that it correlates well with the LC-MS/MS one.</p><p></p><p>Clin Biochem. 2012 Jul;45(10-11):811-5. doi: 10.1016/j.clinbiochem.2012.02.016. Epub 2012 Feb 25.</p><p></p><p>Performance evaluation of Siemens ADVIA Centaur enhanced estradiol assay and a split sample comparison with liquid chromatography-tandem mass spectrometry.</p><p>Chen Y1, Kinney L, Soldin SJ.</p><p>Author information</p><p>Abstract</p><p></p><p>OBJECTIVES:</p><p>The objective of this study was to evaluate the newly developed Siemens ADVIA Centaur enhanced Estradiol (eE2) assay and compare it with a well-established estradiol liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.</p><p></p><p>DESIGN AND METHODS:</p><p>The Siemens eE2 assay was evaluated using the Clinical and Laboratory Standards Institute evaluation protocols. Split patient samples were compared with the eE2 assay, the current ADVIA Centaur E2-6 Ill assay; and LC-MS/MS method by API5000 mass spectrometer.</p><p></p><p>RESULTS:</p><p>Within-run and total imprecision of the eE2 assay demonstrated coefficient of variations of 5.7%, 3.2%, 1.5%, and 10.4%, 7.3%, and 6.8%, at levels of 380, 752, and 2051 pmol/L, respectively. The method comparisons showed: eE2=0.903(E2-6 III) -16.2, R(2)=0.938, average bias=-12.3%; and eE2=0.946(LC-MS/MS)+19.5, R(2)=0.925, average bias: 0%.</p><p></p><p>CONCLUSION:</p><p>The Siemens eE2 assay correlates well with LC-MS/MS. This method is reliable, and appropriate for routine clinical laboratory use.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 10472, member: 3"] I had never heard of it but it seems that it correlates well with the LC-MS/MS one. Clin Biochem. 2012 Jul;45(10-11):811-5. doi: 10.1016/j.clinbiochem.2012.02.016. Epub 2012 Feb 25. Performance evaluation of Siemens ADVIA Centaur enhanced estradiol assay and a split sample comparison with liquid chromatography-tandem mass spectrometry. Chen Y1, Kinney L, Soldin SJ. Author information Abstract OBJECTIVES: The objective of this study was to evaluate the newly developed Siemens ADVIA Centaur enhanced Estradiol (eE2) assay and compare it with a well-established estradiol liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. DESIGN AND METHODS: The Siemens eE2 assay was evaluated using the Clinical and Laboratory Standards Institute evaluation protocols. Split patient samples were compared with the eE2 assay, the current ADVIA Centaur E2-6 Ill assay; and LC-MS/MS method by API5000 mass spectrometer. RESULTS: Within-run and total imprecision of the eE2 assay demonstrated coefficient of variations of 5.7%, 3.2%, 1.5%, and 10.4%, 7.3%, and 6.8%, at levels of 380, 752, and 2051 pmol/L, respectively. The method comparisons showed: eE2=0.903(E2-6 III) -16.2, R(2)=0.938, average bias=-12.3%; and eE2=0.946(LC-MS/MS)+19.5, R(2)=0.925, average bias: 0%. CONCLUSION: The Siemens eE2 assay correlates well with LC-MS/MS. This method is reliable, and appropriate for routine clinical laboratory use. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
advia centaur estradiol e2
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