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A new study explores anti-aging properties of metformin
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<blockquote data-quote="Vince" data-source="post: 28319" data-attributes="member: 843"><p><a href="https://www.excelmale.com/forum/showthread.php?5733-Metformin-interesting-read" target="_blank">Metformin-interesting read</a></p><p></p><p>Medical researchers say that the drug metformin, used for treating type 2 diabetes, could become the world's first anti-aging drug that enables adults to live well beyond 120 years. According to experts, the drug could extend healthy life and lifespan, and stave off illnesses associated with aging, such as Alzheimer's and Parkinson's disease.</p><p></p><p></p><p>Scientists <a href="http://www.dailymail.co.uk/health/article-3338807/Diabetes-pill-help-live-120-Common-treatment-set-trialled-year-hope-stave-illnesses-Alzheimer-s-Parkinson-s.html" target="_blank">believe</a> that metformin, the world's most widely-used diabetes drug, is a good candidate for an anti-aging drug because tests conducted using animals demonstrated the ability of the drug to slow down the aging process.</p><p>Metformin, which <a href="http://www.nature.com/news/anti-ageing-pill-pushed-as-bona-fide-drug-1.17769" target="_blank">suppresses</a> glucose production in the liver and increases sensitivity to insulin, has been used for more than six decades to treat type 2 diabetes and is considered a safe drug for humans.</p><p>Recent <a href="http://news.nationalpost.com/health/no-more-alzheimers-worlds-first-anti-aging-drug-could-let-you-live-more-than-120-years-in-good-health" target="_blank">tests</a>, which show that metformin <a href="http://www.telegraph.co.uk/news/science/science-news/12017112/Worlds-first-anti-ageing-drug-could-see-humans-live-to-120.html" target="_blank">prolongs</a> the lifespan and health of certain species of worms and strains of laboratory mice, have sparked interest in the drug as a possible anti-aging drug.</p><p>A series of tests, <a href="http://www.telegraph.co.uk/news/science/science-news/12017112/Worlds-first-anti-ageing-drug-could-see-humans-live-to-120.html" target="_blank">conducted</a> by a team of Belgian researchers on a species of roundworms, <em>C. elegans</em>, found that metformin <a href="http://blogs.sciencemag.org/pipeline/archives/2015/09/22/the-first-real-anti-aging-trial-in-humans" target="_blank">prolonged</a> the lives of the roundworms by making them age more slowly and keeping them healthier for longer.</p><p>Other trials found that it also prolongs the healthy life and lifespan of certain strains of mice.</p><p></p><p>Read more at <a href="http://www.inquisitr.com/2599362/diabetes-drug-metformin-could-increase-human-lifespan-to-120-years/#M2R9OZIDouWAl1AD.99" target="_blank">Diabetes Drug Metformin Could Increase Human Lifespan To 120 Years</a></p><p>Experts at Cardiff University in the U.K. also pointed to anecdotal evidence that human patients treated with metformin for diabetes live longer than expected, often longer than people without diabetes. The anecdotal evidence is paradoxical because diabetes normally shortens lifespan, as sufferers have a heightened susceptibility to cardiovascular diseases and kidney complications.Based on results of tests on animals, scientists believe metformin could also make humans live beyond 120 years.</p><p>Researchers plan to conduct the first clinical trials of the project, dubbed Targeting Aging with Metformin (TAME), next year to see whether results obtained in animals can also be replicated in humans. Researchers are hopeful of a major breakthrough in the decades-long search for an anti-aging drug.</p><p>The study, to be conducted in the U.S., will involve 3,000 adults aged 70- to 80-years-old, with known risk of cancer, heart disease, and neurodegenerative diseases that cause cognitive impairment, and people who already have one or a combination of the conditions.</p><p>The individuals will be placed on the drug and monitored to see if it exerts significant preventive effect on the disease conditions, or whether it affects the progress of the conditions and overall lifespan of participants.</p><p></p><p>Read more at <a href="http://www.inquisitr.com/2599362/diabetes-drug-metformin-could-increase-human-lifespan-to-120-years/#M2R9OZIDouWAl1AD.99" target="_blank">Diabetes Drug Metformin Could Increase Human Lifespan To 120 Years</a></p></blockquote><p></p>
[QUOTE="Vince, post: 28319, member: 843"] [URL="https://www.excelmale.com/forum/showthread.php?5733-Metformin-interesting-read"]Metformin-interesting read[/URL] Medical researchers say that the drug metformin, used for treating type 2 diabetes, could become the world's first anti-aging drug that enables adults to live well beyond 120 years. According to experts, the drug could extend healthy life and lifespan, and stave off illnesses associated with aging, such as Alzheimer's and Parkinson's disease. Scientists [URL='http://www.dailymail.co.uk/health/article-3338807/Diabetes-pill-help-live-120-Common-treatment-set-trialled-year-hope-stave-illnesses-Alzheimer-s-Parkinson-s.html']believe[/URL] that metformin, the world's most widely-used diabetes drug, is a good candidate for an anti-aging drug because tests conducted using animals demonstrated the ability of the drug to slow down the aging process. Metformin, which [URL='http://www.nature.com/news/anti-ageing-pill-pushed-as-bona-fide-drug-1.17769']suppresses[/URL] glucose production in the liver and increases sensitivity to insulin, has been used for more than six decades to treat type 2 diabetes and is considered a safe drug for humans. Recent [URL='http://news.nationalpost.com/health/no-more-alzheimers-worlds-first-anti-aging-drug-could-let-you-live-more-than-120-years-in-good-health']tests[/URL], which show that metformin [URL='http://www.telegraph.co.uk/news/science/science-news/12017112/Worlds-first-anti-ageing-drug-could-see-humans-live-to-120.html']prolongs[/URL] the lifespan and health of certain species of worms and strains of laboratory mice, have sparked interest in the drug as a possible anti-aging drug. A series of tests, [URL='http://www.telegraph.co.uk/news/science/science-news/12017112/Worlds-first-anti-ageing-drug-could-see-humans-live-to-120.html']conducted[/URL] by a team of Belgian researchers on a species of roundworms, [I]C. elegans[/I], found that metformin [URL='http://blogs.sciencemag.org/pipeline/archives/2015/09/22/the-first-real-anti-aging-trial-in-humans']prolonged[/URL] the lives of the roundworms by making them age more slowly and keeping them healthier for longer. Other trials found that it also prolongs the healthy life and lifespan of certain strains of mice. Read more at [URL="http://www.inquisitr.com/2599362/diabetes-drug-metformin-could-increase-human-lifespan-to-120-years/#M2R9OZIDouWAl1AD.99"]Diabetes Drug Metformin Could Increase Human Lifespan To 120 Years[/URL] Experts at Cardiff University in the U.K. also pointed to anecdotal evidence that human patients treated with metformin for diabetes live longer than expected, often longer than people without diabetes. The anecdotal evidence is paradoxical because diabetes normally shortens lifespan, as sufferers have a heightened susceptibility to cardiovascular diseases and kidney complications.Based on results of tests on animals, scientists believe metformin could also make humans live beyond 120 years. Researchers plan to conduct the first clinical trials of the project, dubbed Targeting Aging with Metformin (TAME), next year to see whether results obtained in animals can also be replicated in humans. Researchers are hopeful of a major breakthrough in the decades-long search for an anti-aging drug. The study, to be conducted in the U.S., will involve 3,000 adults aged 70- to 80-years-old, with known risk of cancer, heart disease, and neurodegenerative diseases that cause cognitive impairment, and people who already have one or a combination of the conditions. The individuals will be placed on the drug and monitored to see if it exerts significant preventive effect on the disease conditions, or whether it affects the progress of the conditions and overall lifespan of participants. Read more at [URL="http://www.inquisitr.com/2599362/diabetes-drug-metformin-could-increase-human-lifespan-to-120-years/#M2R9OZIDouWAl1AD.99"]Diabetes Drug Metformin Could Increase Human Lifespan To 120 Years[/URL] [/QUOTE]
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A new study explores anti-aging properties of metformin
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