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Native testosteorne, just like your body mades (unmodified, unesterified). The good stuff! It's chemically identical to endogeonous T, but because the oral tablet doesn't come from endogenous sources, I wouldn't call it that. But the part stimualted by enclomiphene can be. It's more...

592 ng/dL is not that high. What dose are you taking? In our last trial, we saw peak Total T levels at 1327 ng/dL on average.

Testosterone: https://pubmed.ncbi.nlm.nih.gov/7690364/ That's why oral testosterone pairs well with enclomiphene.

I've never seen a SERM able to raise LH/FSH to baseline levels while on injectable TRT. Dr. Justin Saya has noted this numerous times as well on discussion forums. Maybe a little bit, but not avoiding suppression altogether.

The doc may need to see a clean baseline that's within range, if done within the last 6 months. Otherwise you'd have to go off for a week and retest.

Testosterone itself increases IGF-1 and can counteracts the decrease from Enclomiphene. My own labs show no difference in IGF-1 from baseline (no drugs) on the combination of a higher dose of testosterone + lower dose of enclomiphene.

Yeah, it's pretty amazing you can get Quest/LabCorp level accuracy at home now. I never need to go into the lab anymore unless I need lipids or something else measured.

That's a great question, I'll have to ask the pharmacist. Though you can learn to swallow pills with these tricks: https://www.health.harvard.edu/blog/two-tricks-make-easier-swallow-pills-201411137515 76% of people report having floaters. Most people don't notice them until they're paying...

As I mentioned, there's only so much you can pass through bucally/sublingually. It's a good choice for low-dose drugs like enclomiphene & pregnenolone, it's not a good choice for drugs like testosterone that requires higher dosages. Studies on bucal testosterone like Striant don't get levels...

There's a physiological limit in how much you can absorb sublingually. Sublingual is just no a good delivery vehicle for testosterone. There's no need for "less liver issues," since there are no liver issues (per the research posted above). We do offer enclomiphene/pregnenolone alone. It...

Associational research is not very useful when it comes to Vit D. I suggest exploring the Vitamin D wiki’s studies. It’s not central to this discussion here, so let’s move on. You can take Oral TRT alone if you’re a “T only” purist. But adding a low dose of enclomiphene is generally worth...

How high are your total & free T levels on 474 mg/day?

Yes. It's not strictly necessary, but 5-20 mg sublingual enhances mood & energy, with little downside. In our clinical experience, patients prefer it to enclomiphene alone.

Interesting, thanks for sharing. Its not as easy for clinics to prescribe Oxandrolone and Proviron, especially if you're talking about healthier individuals. Clomid is actually more expensive now that one of the manufacturers shut down. There are now two published trials of enclomiphene and...

Estradiol is easily increased by splitting the daily dosage in half, or lowering the dose. I'm just showing a peak level of 1500+ testosterone just to show how non-suppressive it is even at high levels. Vitamin D toxicity is rare and does not happen until levels are 200+. 100 is perfectly safe...

Bioavailability can be overridden by dose. The dosage is less relevant than the outcome: serum levels. When total testosterone can go above 1500 ng/dl (see screenshot above), it's plenty potent. The enclomiphene/pregnenolone is sublingual. Because the oral testosterone need hundreds of mg, it...

The results are excellent (see my post above). There's no need to add Oxandrolone, given how effective the testosterone alone is. Enclomiphene is also far superior to Clomid in having less side effects.

On September 29, 2023, the FDA included enclomiphene on its 503A bulks list, which makes it clear that it is legal to compound. Oral TRT alone starts at $149/month, and Oral TRT+ (with enclomiphene/pregnenolone) starts at $199/month, with a 12 month commitment and multivitamin purchase. The...

Look at this patient's bloodwork. You ever seen a Total T> 1500 and Free T> 350 with an LH of 5.4 and FSH of 8.9? Remarkable. The clinical trial is being published on Monday on Maximus' website.

It's native, unmodified, unesterified testosterone, just like your body makes. It has several key advantages over testosterone undecanoate (TU) used by the Tlando, Jatenzo, & Kyzatrex: 1) It is bioidentical, so is as close to 'natural' as you can get with an exogenous TRT. 2) It can be...

Why inject GnRH? While TRT downregulates its, enclomiphene upregulates it by block estradiol's negative feedback on GnRH production—thus leading to an increase in secretion of GnRH and subsequently LH and FSH. Thus, doesn't enclomiphene make GnRH supplementation redundant?

That's incorrect guidance. Topical TRT decreases testicular volume, while enclomiphene increases testicular volume significantly (compared to both placebo & TRT). Intranasal TRT will have less LH/FSH suppression (on the order of 20-30% compared to 80-90% with injectable TRT), so it reduces...

Why wouldn't Empower release any enclomiphene? FYI, Maximus prescribes it as a standalone, but can't be taken concurrently with TRT. Natesto has a half-life of 10-100 minutes, while enclomiphene's half-life is 10.5 hours, while testosterone cypionate is 8 days. Generally, faster half life...

Have you considered or tried taking enclomiphene + intranasal testosterone together? The enclomiphene would stimulate endogenous production and likely prevent suppression from a short-acting form of testosterone. You could use the intranasal testosterone more PRN/as needed vs. strictly 3x/day...