Why is it a bad idea to take clomid/gonadorelin while on TRT?

[phalloguy100]

I have read in this and other forums that taking clomid, gonadorelin, or kisspeptin while on TRT is a waste - that those things are used more for PCT, to regain testicular function. But why is it wasteful, or even contraindicated, to use those medications while on TRT? How does one harm the other?

If I wanted to simply keep LH/FSH levels at non-zero values so the testicles keep woking? (I do use hCG but I am wondering about alternatives).

 

[FunkOdyssey]

I have read in this and other forums that taking clomid, gonadorelin, or kisspeptin while on TRT is a waste - that those things are used more for PCT, to regain testicular function. But why is it wasteful, or even contraindicated, to use those medications while on TRT? How does one harm the other?

If I wanted to simply keep LH/FSH levels at non-zero values so the testicles keep woking? (I do use hCG but I am wondering about alternatives).

Because most people run long acting injections at doses too high for Clomid / enclomiphene to work, which makes it a complete waste from an hpta suppression perspective. It's something that might work at 50 mg or less weekly, in a world where everyone runs 100 or more.

If you use normal doses of short acting methods like oral testosterone, low doses of intermediate-acting methods like topicals or prop, or very low doses of long-acting methods, yes, the SERM can work to prevent suppression.

Gonadorelin and kisspeptin may work with very high frequency dosing like cataceous uses (I think 5x daily if memory serves).

 

[phalloguy100]

Interesting... makes me wonder how those gonadotropins/SERMS would work alongside Natesto.

 

[FunkOdyssey]

Interesting... makes me wonder how those gonadotropins/SERMS would work alongside Natesto.

SERMs would probably work very well and increase testosterone AUC in this scenario.

 

[Guided_by_Voices]

I switched from HCG to clomid about 5 months ago and I think I slightly prefer the clomid. I will get bloodwork soon what LH is doing. I use around 80-100mg of cyp per week. I also tried enclomiphene alone and in combination with the clomid, but I seem to do well with just the clomid. I tried it because of Dr. Gordon's views on the importance of having real LH circulating. I don't think this approach was ever given a fair chance do to the influence of the high-dose community.

 

[Mastodont]

I switched from HCG to clomid about 5 months ago and I think I slightly prefer the clomid. I will get bloodwork soon what LH is doing. I use around 80-100mg of cyp per week. I also tried enclomiphene alone and in combination with the clomid, but I seem to do well with just the clomid. I tried it because of Dr. Gordon's views on the importance of having real LH circulating. I don't think this approach was ever given a fair chance do to the influence of the high-dose community.

Fascinating, how much clomid per week and how often, how often do you inject the cyp?

 

[Guided_by_Voices]

25mg clomid twice per week. 45 cyp twice per week.

 

[Mastodont]

25mg clomid twice per week. 45 cyp twice per week.

Be sure to report on the LH once you get there.

 

[Cataceous]

I switched from HCG to clomid about 5 months ago and I think I slightly prefer the clomid. I will get bloodwork soon what LH is doing. I use around 80-100mg of cyp per week. ...

You'll be an outlier if you have non-negligible LH with this TRT dosing. If this fails then you could test my cistanche hypothesis.

 

[Guided_by_Voices]

You'll be an outlier if you have non-negligible LH with this TRT dosing. If this fails then you could test my cistanche hypothesis.

Thanks for reminding me of this. I just ordered some but I'm not going to try it until I do bloodwork.