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    Metformin improves semen and testosterone in men with metabolic syndrome

    Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome


    Fertility and Sterility
    Volume 95, Issue 6, May 2011, Pages 2150–2152


    Forty-five patients (age range: 26 to 44 years) were evaluated. Five patients experienced mild side effects such as nausea and diarrhea without interrupting treatment. The patients’ metabolic and hormone profiles are presented in Table 1. Although no statistically significant differences were observed in the patients’ BMI, waist circumference, or triglyceride levels before and after metformin treatment, the HOMA index and plasma SHBG levels statistically significantly decreased after metformin treatment (P<.001 and P<.001, respectively). The FSH levels were not effected by metformin therapy, but we observed a statistically significant increase in the total testosterone (P<.02), free testosterone (P<.001), and LH (P<.01) levels, and a statistically significant decrease in the E2 (P<.01) level after metformin treatment.
    Metformin improved sperm quantity and quality.

    NOTE:

    What is oligoasthenoteratozoospermia?

    Oligoasthenoteratozoospermia (OAT) is a condition that includes oligozoospermia (low number of sperm), asthenozoospermia (poor sperm movement), and teratozoospermia (abnormal sperm shape). OAT is the most common cause of male subfertility. Subfertility is when a man cannot get a woman pregnant after 1 year of regular sex without birth control.

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