Alzheimer's Patients Have High SHBG

Buy Lab Tests Online

Nelson Vergel

Founder, ExcelMale.com
Xu J, Xia LL, Song N, Chen SD, Wang G.

Testosterone, Estradiol, and Sex Hormone-Binding Globulin in Alzheimer's Disease: A Meta-Analysis.
Curr Alzheimer Res. http://www.eurekaselect.com/node/13...lobulin-in-alzheimers-disease-a-meta-analysis


BACKGROUND: Previous studies suggested that plasma sex hormones may be implicated in the pathogenesis of Alzheimer's disease (AD). However, the relationship between sex hormones and AD remains unclear.


OBJECTIVE: To systematically review and quantitatively analyze studies observing plasma total testosterone (TT), estradiol (E2), and sex hormone-binding globulin (SHBG) levels among AD patients. METHODS: Medline, EMBASE, the Cochrane Library, and PsycINFO(R) were searched for studies published prior to March 28th, 2014. Published studies that reported plasma levels of TT, E2, and SHBG in AD and matched controls were included in the present meta-analysis.


RESULTS: Meta-analysis was performed using the random effects model, expressing continuous outcomes as the mean difference (MD) between AD and control populations. The 95% confidence intervals (CI) were also calculated. No differences were found in plasma levels of TT and E2 between AD and matched controls (TT MD -0.17 nmol/l, 95%CI -0.54, 0.20; E2 MD -1.16 pmol/l, 95%CI -9.85, 6.83). Plasma levels of SHBG were significantly increased in AD patients compared to healthy controls (SHBG MD 12.94 nmol/l, 95%CI 2.68, 23.20).


CONCLUSIONS: Evidence that SHBG and the bioavailability of functional sex hormones in plasma may be linked to the pathogenesis of AD.
 
Last edited:
Defy Medical TRT clinic doctor

Re-Ride

Member
["Plasma levels of SHBG were significantly increased in AD patients compared to healthy controls (SHBG MD 12.94 nmol/l, 95%CI 2.68, 23.20)"]

Nelson, shouldn't your title be "Up-regulated SHBG serum levels found in Alzheimer patients" ? The AD's had higher not lower SHBG compared to the controls.
 
Buy Lab Tests Online

Sponsors

bodybuilder test discounted labs
Defy Medical TRT clinic
nelson vergel coaching for men
Discounted Labs
TRT in UK Balance my hormones
Testosterone books nelson vergel
Register on ExcelMale.com
Trimix HCG Offer Excelmale
Thumos USA men's mentoring and coaching
Testosterone TRT HRT Doctor Near Me
how to save your marriage

Online statistics

Members online
4
Guests online
8
Total visitors
12

Latest posts

Top