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    Penis Injections for Hard Erections: TRIMIX

    Trimix or Quadmix—Available by prescription from compounding pharmacies. These are mixtures of prostaglandins and papaverine that increase blood flow and retention into the penis. Prostaglandins are mediators and have a variety of strong physiological effects, such as regulating the contraction and relaxation of smooth muscle tissue. Prostaglandins are not hormones and they are not produced at one discrete site, but rather in many places throughout the human body.


    Trimix is a mixture of two prostaglandins (phentolamine and alprostadil) plus papaverine (a vasodilator medication) that increase blood flow to the penis and cause strong and lasting erections, with or without sexual stimulation. These compounds appear to act together to increase arterial inflow, dilate smooth muscles,and restrict venous outflow promoting erectile rigidity with greater success and in smaller doses than if these compounds were used as single therapies.


    An example of a dosage combination for tri-mix is 10 micrograms of alprostadil, 500 micrograms of phentolamine and 15 mg of papaverine. Dosing of tri-mix preparations has not been standardized.



    Trimix is injected directly into the side of the penis through a fine- gauge “insulin-style” needle in very small amounts (0.1-0.5cc) that increase blood flow to the penis. It results in strong and lasting erections. The main potential side effect are hematomas(bruising), fibrosis if used too frequently and on the same injection site,pain, and dangerously long-lasting erections(priaprism). Priaprism may sound great but this can literally kill your penis by causing gangrene of the tissue after stagnant blood coagulates inside it. I know men who had to go to an emergency room 8 hours after having used too much Trimix and have the blood drained from their penis. To ensure perfect injection technique and dosing, it is imperative to be trained on how to dose this with the help of an urologist.



    Compounding pharmacies sell two types of Trimix formulations: Freeze dried (powder to be mixed later with water) or pre-mixed vials. Some men find the freeze dried form not to be as effective.


    It is extremely important to remember never to use Viagra, Cialis, or Levitra before or at the same time as you use Trimix. This is a dangerous combination that can increase the risk of priaprism. Be particularly careful with Cialis since it can stay in your blood stream for a longer time. I know someone who had priaprism since he had forgotten he had taken Cialis two days before using Trimix.


    Most men who use Trimix love it, even if they have had to learn the hard way about priaprism during one instance.Most of these men did not respond well nor had too many side effects to oral agents like Viagra or Cialis.

    Some men who do not respond completely with TRIMIX use a quad mixture (QUADMIX) of phentolamine, papaverine, prostaglandin E1 and atropine. Others who may have pain associated with a TRIMIX injection use a bi mixture (BIMIX) of phentolamine and papaverine.

    A single agent FDA approved drug that only has Prostaglandin E1 can be compounded generically or is also dispensed as injectable alprostadil either as Caverject Impulse® or Edex®. These two products are not as effective as TRIMIX but may be covered by some insurance companies. Their copay may be higher than paying for TRIMIX, though. The injection volume is also 10 times larger than TRIMIX.

    For instructions on how to inject Trimix, read:

    Instructions and general information about Trimix


    Video: How to Inject Trimix



    For instructions for physicians on how to treat priaprism in the unfortunate case that it happens:



    Priapism in Emergency Care



    A 10 cc bottle of Trimix can cost from $70 to $100 in compounding pharmacies. If a dose of 0.15 cc is needed per erection, this bottle canbe good for 67 erections. In comparison with Cialis and Viagra($16 a pill), this option seems economical. Asks us if you need a referral to compounding pharmacies.

    You will need a prescription written as : TRIMIX (10 micrograms of alprostadil, 500 micrograms of phentolamine and 15 mg of papaverine) , 5 mls, as directed. Make sure you ask for insulin syringes (30 gauge, 1/2 inch needles), and alcohol swabs with your order.


    Factsheet: Penile Injection Therapy

    Trimix Injections for Hard Erections- Part 2







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    Last edited by Nelson Vergel; 10-01-2016 at 12:11 PM.

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    Super Moderator Nelson Vergel's Avatar
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    Can't get a Trimix prescription?
    http://www.excelmale.com/trimix/

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    Last edited by Nelson Vergel; 09-12-2015 at 11:21 PM.

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    Super Moderator Nelson Vergel's Avatar
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    I have used a trimix solution for almost 18 months with less success than I expected. I started out with my urologist putting me on a single ...


    Different Results With Trimix [Archive] - ExcelMale.com

    www.excelmale.com/archive/index.php/t-1608.html

    Has anyone experienced different results with Trimix depending on which side you inject. With a dosage of 0.17 cc, I get firm erections when injecting on the ...


    Trimix the Ultimate Solution for ED

    www.excelmale.com/showthread.php?783-Trimix-the-Ultimate...

    The injection is no big deal and if you ask to have the Trimix formulated with 2% lidocaine you won't feel the injection as all! Here's the page ...


    Has anyone had erections lasting more than 3 hours with Trimix?

    www.excelmale.com/showthread.php?1183-Has...had...Trimix

    I had just such an experience with Trimix. On my first try I had an 8 hour erection. Sudafed, a hot bath, and squeezing my member helped it ...


    When Testosterone Is Not Enough

    www.excelmale.com/forumdisplay.php?50-When...Trimix...

    Sticky Thread Sticky: Penis Injections for Hard Erections: TRIMIX ... bimix, caverjet, papaverine, phetolamine, prostagladin e1, quadmix, trimix 3 Attachment (s).


    How long does Trimix work once injected...

    www.excelmale.com/showthread.php?3527-How-long...Trimix...

    If I injected, then went out to dinner, would Trimix still be hanging around waiting to help out, say an hour later... That would allow more ...


    Trimix Access Program

    www.excelmale.com/trimix/

    HOW THE TRI-MIX PROGRAM WORKS: Complete the health questionnaire and consent to treat forms located online: http://defymedical.com/resources/forms


    Different Results With Trimix

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    Has anyone experienced different results with Trimix depending on which side you inject. With a dosage of 0.17 cc, I get firm erections when ...


    Trimix

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    The closest clinic that advertise trimix are in Dallas or Phoenix. Are there any online clinics or sources that anyone has had good results with?


    The closest clinic that advertise trimix are in Dallas or Phoenix. Are there any online clinics or sources that anyone has had good results with?


    Trimix from Defy

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    Using TriMix in a gel form for ED

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    Trimix get it down help!!

    www.excelmale.com/showthread.php?7244-Trimix-get-it-down...

    Join Date: Sep 2013; Location: Houston, Texas, United States; Posts: 5,350. Has anyone had erections lasting more than 3 hours with Trimix?


    Trimix advice, soft glans, allergy meds

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    Took first .05 dose of trimix. Worked for 2.5 hours, then I did some things to get it down. (Squats worked) so I will reduce the dose. I noticed that ...








  8. #7
    Super Moderator Nelson Vergel's Avatar
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    Trimix starting dosage

    www.excelmale.com/showthread.php?7195-Trimix-starting-dosage

    Received my prescription of Trimix from defy. The recommended starting dose is . 5 ml. which will be halfway to the 1 ml mark correct?


    Traveling With Trimix

    http://www.excelmale.com/showthread....raveling-With-Trimix

    Any suggestions as to which travel cooler pack is best for keeping Trimix cool for extended time.


    HCG and TRIMIX ACCESSORIES – ExcelMale store

    www.excelmale.com/store/product.../hcg-and-trimix-accessories/

    HCG and TRIMIX ACCESSORIES. Showing all 3 results. Default sorting, Sort by popularity, Sort by average rating, Sort by newness, Sort by price: low to high ...


    Any experience with Trimix use several times over a few days?

    www.excelmale.com/showthread.php?7055-Any...Trimix-use...

    I use Cialis or Viagra without great results. I've thought about Trimix, and I wonder if anyone else has used Trimix more than once a day,


    Trimix the Ultimate Solution for ED [Archive] - ExcelMale.com

    www.excelmale.com/archive/index.php/t-783.html

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    Different Results With Trimix - Page 2

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    Trimix after sex??

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    Has anyone used Trimix as a second chance, so to speak?? So after having sex and cumming, injecting and starting again... Thanks.


    Why would Trimix not work while Viagra does?

    www.excelmale.com/showthread.php?2987-Why-would-Trimix...

    Ended up giving me THREE shots of Trimix total with only about a 60% erection. He now wants me to have a discussion about penile implant ...


    Thread: When Testosterone Doesn't Lead to Better Erections

    http://www.excelmale.com/showthread....n-Testosterone...

    Trimix is a mixture of two prostaglandins (phentolamine and alprostadil) plus papaverine (a vasodilator medication) that increase blood flow to ...


    Clinic wants to charge high price for TRIMIX

    http://www.excelmale.com/showthread....77-Clinic...to...TRIMIX

    Howdy, I just joined. Went to a clinic this week. They introduced me to Trimix, but gave a big price to get started, like $958. Is it that high priced?

  9. #8
    Super Moderator Nelson Vergel's Avatar
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    Risks of Penile Injections:


    1) Dizziness – a small per cent of men will experience light headedness with injection, if you experience this, sit/lie down immediately.

    2) Penile Curvature – The injection sites can scar in some men depending on which medication you are on (<1-4%) causing a bend in the penis with erections. If this develops, notify your MD.

    3) Pain – Most men rate their pain with injection at 1/10 (minimal to no pain) with injection. Depending on the medication, however, rates of pain from the medications themselves (not the needle stick) can occur in up to 15% of men.

    4) Priapism – This is most concerning side effect for injections, and it involves an erection that lasts longer than 4 hours in the absence of sexual stimulation. Typically it is extremely painful, and the penis is extremely rigid. If untreated (typically > 4-24 hours), it can result in permanent erectile dysfunction that would no longer be responsive to injection therapy. Priapism occurs in 1-5% of patients using injections and most often occurs when using too much medication, or mixtures of erections with other erectile aides. The goal length of erection is 30-45 minutes with injection, or resolution with ejaculation. If you experience an erection for > 2 hours do the following:

    Priapism Treatment Pathway – Follow these steps until the erection softens – if the erection becomes “bendable” you are okay.

    Penile Injection Handout

    1) Ejaculate (sometimes more than once is helpful).

    2) Apply an ice pack to the penis for 30 minutes to an hour.

    3) Take 2, 30 mg tabs of Sudafed for a total dose of 60 mg (this is available behind the counter, ask your pharmacist to help if necessary). Do not use the new formulation of Sudafed so talk to the pharmacist to get you the old formulation. You will be asked to provide your ID since meth drug dealers use the old formulation to make meth, so the government wants to keep close monitoring of anyone buying it frequently. You do not need a prescription. For faster action, chew it!


    4) If you are out of town or cannot reach any urologist, proceed to the emergency department and give them this instruction sheet:

    Emergency Room Instruction for Priapism

    1. If penis is erect for > 3 hours, begin by using a 26-27g needle (1/2 – 5/8 inch) attached to a 1 cc syringe. Inject phenylephrine 0.1 mg/ml or epinephrine 1:100,000 (Inject 1 cc of solution into corpora cavernosa).

    2. If no results in 2 minutes, inject the opposite corpora with 1 cc of the phenylephrine 0.1 mg/ml or 1:100,000 strength epinephrine.

    3. Wait 20 minutes. If still no results, proceed.

    4. Place tourniquet around the base of the penis, but do not tighten it until the needle is in place.

    5. Insert a 21g or greater butterfly needle and withdraw 15-20 ml of blood to release tension.

    6. Irrigate with 15-20 ml normal saline.

    7. If erection remains, irrigate with 5-15 ml of epinephrine solution (0.3 ml of 1:1000 epinephrine to 30 ml of normal saline).

    8. Repeat this no more than 2 times and remove as much fluid as possible after each irrigation.

    9. Remove tourniquet.

    10. Watch the pulse rate of the patient as an increase would indicate the corpora are draining and no further irrigation is needed.

    11. Remove the needle and apply pressure over the area of injection for 5 minutes.

    12. Observe the patient for at least 5 more minutes.

    13. If more definitive treatment is needed, call the urologist. Patient instructions following priapism:
    ‐ Use an ice pack to area for 30 minutes to 1 hour at home.
    ‐ No intercourse for 48 hours.
    ‐ No more injections until advised by your managing urologist!

    Source: Department of Surgery | Division of UrologySouthern Illinois University School of Medicine

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