Testosterone therapy benefits men with Crohn’s disease

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Nelson Vergel

Founder, ExcelMale.com
Testosterone therapy in men with Crohn’s disease improves the clinical course of the disease: data from long-term observational registry study

Mahmoud Nasser

Hormone Molecular Biology and Clinical Investigation. ISSN (Online) 1868-1891, ISSN (Print) 1868-1883

Abstract


Background: Crohn’s disease is an inflammatory chronic bowel disease characterized by an imbalanced production of pro-inflammatory mediators (tumor necrosis factor-α) and an increased recruitment of leukocytes to the site of inflammation. Low serum testosterone is associated with an increase in inflammatory factors, while testosterone administration reduces them. There is evidence for an immunomodulatory effect of testosterone on differentiation of regulatory T cells.

Materials and methods: The research was carried out in clinics in Germany and Syria. The study was a cumulative, prospective, registry study with an increasing number of men over time receiving testosterone. While men diagnosed with Crohn’s disease received appropriate treatment for Crohn’s disease, they were tested for testosterone deficiency (cut-off point ≤12.1 nmol/L). In total, 92 men received parenteral testosterone undecanoate 1000 mg/12 weeks for up to 7 years. Fourteen men opted not to receive testosterone and served as a comparison group.

Results: In men receiving testosterone, the Crohn’s Disease Activity Index declined from 239.36±36.96 to 71.67±3.26 at 84 months (p<0.0001 vs. baseline). C-reactive protein levels decreased from 12.89±8.64 to 1.78±1.37 mg/L at 84 months (p<0.0001 vs. baseline). Leukocyte count decreased from 11.93±2.85 to 6.21±1.01×109/L (p<0.0001 at 84 months vs. baseline). No changes were observed in the comparison group. There were no significant side effects of testosterone.

Conclusions: Normalizing serum testosterone in hypogonadal men with Crohn’s disease had a positive effect on the clinical course, also evidenced by biochemical parameters. Testosterone administration appeared safe.
 
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iman55

New Member
wondering if there is anything else to take for regaining my muscle size?
taking test cyp., hcg, armidex
still at 9-10%bodyfat, just a lot smaller
 

DLK

Member
iman, the problem with trying to put on weight with crohns is that you don't have the ability to aborb the same amount of nutrients as someone without it. your body just cant get enough calories, protein, etc. aborbed through the intestinal tract to gain.
 

Nelson Vergel

Founder, ExcelMale.com
We had the same problem in HIV wasting. I bet anabolic steroids like nandrolone and oxandrolone can help if you can have a doctor justify them as treatment of illness related unintentional weight loss.
 
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