Testosterone Replacement Therapy Benefits Outweigh Risks: AACE

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CoastWatcher

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Published on AACE Online Newsroom (http://media.aace.com) on 5/15/15 3:15 pm EDT

Testosterone Replacement Therapy Benefits Outweigh Risks, Say Researchers

Release Date:
Friday, May 15, 2015 3:15 pm EDT


Terms:

AACE Annual Meeting Press Releases


Dateline City:
NASHVILLE, Tenn.


NASHVILLE, Tenn.--(BUSINESS WIRE)--The benefits of testosterone replacement therapy (TRT) to treat low testosterone in both men and women substantially outweigh any risks, according to a panel of researchers presenting today at the American Association of Clinical Endocrinologists' 24[SUP]th [/SUP]Annual Scientific and Clinical Congress.
Low testosterone – also known as low T – is characterized by lack of sex drive, diminishing energy, and hair, bone and muscle mass loss.
The panel's comments were in response to the FDA's March 2015 safety alert cautioning that the benefits and safety of testosterone medications prescribed for age-related low testosterone levels have not been established. In that statement, the FDA also called for manufacturers to include labeling about a possible increased risk of heart attacks and strokes.
Endocrinologist Sandeep Dhindsa, MD, asserted that the FDA provided no meaningful definition of aging, leaving it unclear whether or not age restrictions for testosterone therapy also apply to middle-aged individuals. Dr. Dhindsa added that the safety alert does not address the role that testosterone decline itself plays in common co-morbidities such as obesity and type 2 diabetes at all ages, including adolescents and young men.
“Any patient being considered for testosterone replacement therapy should undergo a thorough diagnostic work-up,” Dr. Dhindsa said. “The decision to replace testosterone therapy should be guided by the signs, symptoms and testosterone concentrations rather than the underlying cause,” he said.
Susan Davis, MBBS, FRACP, PhD and Director of the Women's Health Research Program in the School of Public Health and Preventive Medicine, Monash University, Melbourne, also touted the safety and efficacy of TRT in women experiencing hypoactive sexual desire disorder (HSDD), a condition that persistently affects female sexual function, profoundly impairing quality of life.
“Testosterone has been used to treat women with HSDD for decades with no evidence of emergent adverse events and should be seen as an effective and safe management option not just for sexual function, but also for effects on muscle and bone,” Dr. Davis said.
Their comments aligned with the soon-to-be-published AACE Reproductive Endocrinology position statement on the association of testosterone and cardiovascular risks, which notes that there is no compelling evidence that TRT either increases or decreases cardiovascular risks and concludes that testosterone therapy favorably changes many cardiovascular risk factors by decreasing fat mass, increasing muscle mass and decreasing insulin resistance.
To read additional press releases about the AACE 24[SUP]th[/SUP] Annual Scientific and Clinical Congress in Nashville, please visit media.aace.com or use the Twitter hashtag #AACE15.
About the American Association of Clinical Endocrinologists (AACE)
The American Association of Clinical Endocrinologists (AACE) represents more than 7,000 endocrinologists in the United States and abroad. AACE is the largest association of clinical endocrinologists in the world. A majority of AACE members are certified in endocrinology, diabetes and metabolism and concentrate on the treatment of patients with endocrine and metabolic disorders including diabetes, thyroid disorders, osteoporosis, growth hormone deficiency, cholesterol disorders, hypertension and obesity. Visit our site at www.aace.com.
About the American College of Endocrinology (ACE)
The American College of Endocrinology (ACE) is the educational and scientific arm of the American Association of Clinical Endocrinologists (AACE). ACE is the leader in advancing the care and prevention of endocrine and metabolic disorders by: providing professional education and reliable public health information; recognizing excellence in education, research and service; promoting clinical research and defining the future of Clinical Endocrinology. For more information, please visit www.aace.com/college.

Language:
English


Contact:
The American Association of Clinical Endocrinologists (AACE)
Amy Johnson, 904-400-0884
[email protected]

Source URL: http://media.aace.com/press-release...terone-replacement-therapy-benefits-outweigh-













The American Association of Clinical Endocrinologists respond to the FDA's March 2015 safety alert with a strong statement in support of TRT.
 
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Defy Medical TRT clinic doctor

CoastWatcher

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However, they do not appear to have updated their clinical practice guidelines for treating hypogonadism. These guidelines still state that 100 - 150mg/IM every two weeks is a reasonable dose.
 
Hey Coastwatcher........I couldn't get the article to pull up. Do you think you can copy and paste it or send an attachment? When I click on the link you provided, the URL says page cannot be found. Thanks!

Curt
 
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