Vitamin D and Semen Quality: Disappointing Study Results

Buy Lab Tests Online

CoastWatcher

Moderator
Many men with hypogonadism present with dramatically low levels of Vitamin D. Animal models and cross-sectional cohort studies suggest that Vitamin D may have a beneficial role in male reproduction. A randomized clinical set out to determine the effect of 25-hydroxyvittamin D and calcium supplementation on the semen quality of infertile men. The results were disappointing.

  • A total of 1427 infertile men were screened to include 330; 1002 men did not meet inclusion criteria and 95 did not wish to participate.
  • The active group received cholecalciferol 300,000 IU initially, then 1400 IU cholecalciferol and 500 mg of calcium daily for 150 days; the other group received placebo.
  • Serum concentrations of 25OHD and 1,25-dihydroxyvitamin D3 were significantly higher in men in the treatment group compared with the placebo group.
  • Vitamin D supplementation was not associated with changes in semen parameters, although spontaneous pregnancies tended to be higher in couples in which the man was in the treatment group [7.3% vs 2.4%, Δ5.0% (-0.6%; 10.5%)]. Vitamin D treatment in a subgroup of oligozoospermic men increased the chance for a live birth compared with placebo [35.6% vs 18.3%, Δ17.3% (1.6%; 32.9%)].
  • Moreover, serum inhibin B levels were higher in men deficient in vitamin D who were randomly assigned to receive high-dose vitamin D [193 pg/mL vs 143 pg/mL, Δ49 pg/mL (8; 91 pg/mL)]; however, the increase in sperm concentration was not significantly higher than in the placebo group (P = 0.07).
  • High-dose vitamin D supplementation did not improve semen quality in vitamin D-insufficient infertile men.
  • The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D-deficient men may be of clinical importance and warrant verification by others.
"Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial," Journal of Clinical Endocrinology and Metabolism, 2018, https://www.ncbi.nlm.nih.gov/m/pubmed/29126319/
 
Defy Medical TRT clinic doctor
Buy Lab Tests Online
Defy Medical TRT clinic

Sponsors

enclomiphene
nelson vergel coaching for men
Discounted Labs
TRT in UK Balance my hormones
Testosterone books nelson vergel
Register on ExcelMale.com
Trimix HCG Offer Excelmale
Thumos USA men's mentoring and coaching
Testosterone TRT HRT Doctor Near Me

Online statistics

Members online
9
Guests online
6
Total visitors
15

Latest posts

bodybuilder test discounted labs
Top