Article: Yet Another Review of Testosterone and Heart Attacks

Demonstrated benefits of T [testosterone] included sexual activity and desire, physical activity, and mood. There were 9 major adverse CV [cardiovascular] events (MACE) in the T arm and 16 in the placebo arm. No study reported increased MACE with TTh [testosterone therapy]. A 3y RCT [randomized clinical trial] showed no difference in carotid atherosclerosis. Several large observational studies reported reduced CV events with TTh, including one showing progressively reduced CV and mortality risk with greater duration of TTh. Men whose serum T normalized with TTh had reduced risk of MI [myocardial infarction] and death compared with men whose T levels failed to normalize.

We conclude that existing evidence fails to support increased CV risk with TTh; on the contrary, there is evidence suggestive of real-world CV benefits. Finally, existing evidence provides benefits of TTh in older men without known etiology for T deficiency.

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