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    Anyone currently using metformin and getting it online?

    Anyone currently using metformin and getting it online? If so, where from and do you feel it is working for you? What benefits are you getting? Any issues?

    Last edited by Nelson Vergel; 02-28-2018 at 04:23 PM.

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    Help Excelmale

    Defy
     

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    Moderator Vince's Avatar
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    Here's an old thread of mine you may like to read.
    Last edited by Nelson Vergel; 02-28-2018 at 04:24 PM.
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

  4. #3
    I have a script from Defy for it. I'm using it in an attempt to get my HCT down. Last labs 6 mos ago showed that it had not gone up. I also use Grapefruit Seed Extract. I'm due to have new labs and will see if its working or not.

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    Quote Originally Posted by Hoosier52 View Post
    I have a script from Defy for it. I'm using it in an attempt to get my HCT down. Last labs 6 mos ago showed that it had not gone up. I also use Grapefruit Seed Extract. I'm due to have new labs and will see if its working or not.
    I don't believe that metformin will lower your HCT, were you told that by a doctor?
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

  6. #5
    Quote Originally Posted by Vince View Post
    I don't believe that metformin will lower your HCT, were you told that by a doctor?
    Read studies online. Dr. Saya approved when I inquired about using it so I assume he must agree.

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  8. #7
    Low hematocrit is a common side effect of many illnesses and of drug therapies like metformin. Reductions in kidney function that occur in diabetes can also cause lower hematocrit values.

    https://www.diabeteshealth.com/diabetes-and-anemia/

  9. #8
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    Low hematocrit is a common side effect of many illnesses and of drug therapies like metformin. Reductions in kidney function that occur in diabetes can also cause lower hematocrit values. Hematocrit is part of the calculation that all glucose monitors use for measuring glucose.

    Diabetes and Anemia: | Diabetes Health

    www.diabeteshealth.com/diabetes-and-anemia/
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

  10. #9
    Quote Originally Posted by Matt Leiser View Post
    Anyone currently using metformin and getting it online? If so, where from and do you feel it is working for you? What benefits are you getting? Any issues?
    I'm using it, and found that it helps bring my average glucose level down. I also had my telomeres tested in December, and i was concerned that due to poor sleep quality (don't know if it is from stress, or sleep apnea - I do use a CPAP machine, or both) my telomeres would have been adversely impacted. However, I was pleased to see that they are above average. I began to wonder if that is partially due to taking 2500mg of metformin daily.

    There are a number of articles about the positive relationship between metformin and telomeres, like this one: https://ampkprogeriahiv.wordpress.co...hiv-1-latency/

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    I started metformin today. 500 mgs twice daily. Think I’m going to start with one at night for a week then move to twice a day. Give my gut a chance to adapt to it.

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    Moderator Vince's Avatar
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    Quote Originally Posted by Matt Leiser View Post
    I started metformin today. 500 mgs twice daily. Think I’m going to start with one at night for a week then move to twice a day. Give my gut a chance to adapt to it.
    You may wish to supplement with B12, metformin can lower your B12 levels. I believe Metformin ER is a better choice.
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

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    Quote Originally Posted by Vince View Post
    You may wish to supplement with B12, metformin can lower your B12 levels. I believe Metformin ER is a better choice.
    Im currently supplementing 600 mcgs. Is that sufficient or do you think I need to increase?

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    Quote Originally Posted by Matt Leiser View Post
    Im currently supplementing 600 mcgs. Is that sufficient or do you think I need to increase?
    The best way to know is checking your A1C and fat fasting glucose. I do believe the minimum dose should be 1000mg daily.
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

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    Quote Originally Posted by Matt Leiser View Post
    Im currently supplementing 600 mcgs. Is that sufficient or do you think I need to increase?
    That dose sounds good to me. You don't want to OD on B12 which could happen if you are eating right.

    Recommended Daily Allowance

    The Institute of Medicine's Food and Nutrition Board recommends that healthy adult men and women over 19 years old consume 2.4 micrograms of vitamin B-12 each day. Pregnant women need 2.6 micrograms daily and women who are breastfeeding need 2.8 micrograms daily. However, due to absorption rate decreasing with age, people over age 50 may need as much as 500 to 1,000 micrograms of supplemental vitamin B-12 each day.
    ===============
    Examples of good sources include eggs, milk, yogurt and cheese. These foods provide between 10 and 19 percent of the RDA of vitamin B-12 per serving. Foods that have 20 percent or more of the vitamin's RDA in every serving are considered excellent sources and include 3 ounces of clams, 3 ounces of beef, 1 cup of vitamin-fortified breakfast cereal or 3 ounces of fish, such as salmon, trout, tuna or haddock.

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    Quote Originally Posted by FeelingLost View Post
    That dose sounds good to me. You don't want to OD on B12 which could happen if you are eating right.
    I hope you're only joking about the OD.
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

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    Quote Originally Posted by Vince View Post
    I hope you're only joking about the OD.
    Sorry Vince I did not mean overdose as in dying. Just taking too much is bad for you.
    Can you take too much b12 in a day?

    Don't take more than 100 milligrams a day, which is the upper tolerable limit set by the federal government. Adults of all ages need 2.4 micrograms a day of vitamin B12; there is no upper tolerable limit for B12 because high doses are considered safe for most people.

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    Quote Originally Posted by FeelingLost View Post
    Sorry Vince I did not mean overdose as in dying. Just taking too much is bad for you.
    My B12 are well over the high range, my lipidologist told me nothing to worry about. High ranges of B12 will not hurt you.
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

  19. #18
    Super Moderator Nelson Vergel's Avatar
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    I highly recommend to read this article and watch the video in this post:

    Is Metformin a Miracle Drug?

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    Quote Originally Posted by Nelson Vergel View Post
    I highly recommend to read this article and watch the video in this post:

    Is Metformin a Miracle Drug?
    Thanks Nelson! This video presentation was the exact reason I talked to my doctor about trying Metformin.

  21. #20
    Some are calling it “vitamin M” and I’ve heard they’re trying to put it in the water supply now (okay that one is a joke). It’s a good drug, as drugs go, but as with everything comes with potential side effects.
    Lead Physician & Medical Director
    www.defymedical.com

    NOTE: Comments on this forum are NOT medical advice and are no substitute for individualized patient care. Comments on this forum do not constitute or establish a physician-patient relationship. Please consult your personal physician prior to initiating or changing ANY treatment regimen.

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    Super Moderator Nelson Vergel's Avatar
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    I had to stop it since it has an interaction with integrase inhibitors (HIV med) that made my CPK and body aches increase. It's too bad since I actually loved the way my gut felt. I lost 6 pounds but regained them after stopping.

    People with kidney dysfunction should be careful also.

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    I’ve learned quite a bit researching this drug, but most importantly, never trust a fart in the first few days...

  24. #23
    I do not have diabetes. My doc asked me about taking this after my blood test at end of 2017. Glucose was elevated, and I said no way I am not going to be diabetic. I checked it at work a week later first thing in the morning with a good meter, 91. I ate breakfast and retested 102. 2 hours later 93, ate lunch then tested at 2:30 and my glucose was 92.

    Having read this thread, if I take this will it have side effects If I dont have the "D". DOC talked me into taking Berberine 500mg a day.

    I was supposed to take a statin 10 years ago for my lipids and I refused it. Doc just told me my pipes are wide open for having eleveted lipids. However, my homocysteine is elevated.

    I eat keto, no sugar, very low carb, but I like some bourbon at night when I get home. Is this safe for me to take, or should I just stick to the Berberine?

  25. #24
    Quote Originally Posted by blackebob View Post
    I do not have diabetes. My doc asked me about taking this after my blood test at end of 2017. Glucose was elevated, and I said no way I am not going to be diabetic. I checked it at work a week later first thing in the morning with a good meter, 91. I ate breakfast and retested 102. 2 hours later 93, ate lunch then tested at 2:30 and my glucose was 92.

    Having read this thread, if I take this will it have side effects If I dont have the "D". DOC talked me into taking Berberine 500mg a day.

    I was supposed to take a statin 10 years ago for my lipids and I refused it. Doc just told me my pipes are wide open for having eleveted lipids. However, my homocysteine is elevated.

    I eat keto, no sugar, very low carb, but I like some bourbon at night when I get home. Is this safe for me to take, or should I just stick to the Berberine?
    We share similar histories. I do not have diabetes, but like you and many, many, many others I have a history of other than normal blood sugars. Although strongly associated with inflammatory processes, the etiology of pre-diabetes is usually unclear, and by no means does it inevitably progress to full-blown diagnosed diabetes. In fact only about 35-40% of those with prediabetes will do so. But you are still right to be concerned. While the majority of pre-diabetics do not progress to diabetes, pre-diabetes is not a benign condition. Pre-diabetics, e.g., experience serious cardiovascular events (stroke and heart attacks) at significantly higher rates than those with normal blood sugars.

    Berberine is not something to fool around with. It does seem to work to some degree, but it may do so by affecting your liver in potentially dangerous ways. It has not undergone the rigorous testing process to which all FDA-approved prescription drugs are subjected, and my view is that it currently should not be prescribed for the treatment of diabetes or pre-diabetes.

    Metformin is a good drug with a good track record. It has been around for many decades and is generally very well-tolerated with almost no serious side effects noted except for the rare possibility of lactic acidosis in those with existing kidney disease. Metformin has occasionally been linked in the literature to a decrease in serum Vitamin B-12, so one might want to have that tested when starting metformin to have a baseline (and perhaps take a low-dose B-complex vitamin or multivitamin with Bs if you don’t already; high doses of B-12 probably aren’t indicated).

    I am on metformin and it enabled me to achieve basically normal blood sugars. You may want to consider discussing this with a doctor with experience in the treatment of pre-diabetes and diabetes. For further general information and discussions of treatment protocols for pre-diabetes, see this site and Dr. Richard Bernstein's seminal book on the subject, Diabetes Solution.

    You should consult your doctor before taking any medication, including metformin.

  26. #25
    Quote Originally Posted by dnfuss View Post
    We share similar histories. I do not have diabetes, but like you and many, many, many others I have a history of other than normal blood sugars. Although strongly associated with inflammatory processes, the etiology of pre-diabetes is usually unclear, and by no means does it inevitably progress to full-blown diagnosed diabetes. In fact only about 35-40% of those with prediabetes will do so. But you are still right to be concerned. While the majority of pre-diabetics do not progress to diabetes, pre-diabetes is not a benign condition. Pre-diabetics, e.g., experience serious cardiovascular events (stroke and heart attacks) at significantly higher rates than those with normal blood sugars.

    Berberine is not something to fool around with. It does seem to work to some degree, but it may do so by affecting your liver in potentially dangerous ways. It has not undergone the rigorous testing process to which all FDA-approved prescription drugs are subjected, and my view is that it currently should not be prescribed for the treatment of diabetes or pre-diabetes.

    Metformin is a good drug with a good track record. It has been around for many decades and is generally very well-tolerated with almost no serious side effects noted except for the rare possibility of lactic acidosis in those with existing kidney disease. Metformin has occasionally been linked in the literature to a decrease in serum Vitamin B-12, so one might want to have that tested when starting metformin to have a baseline (and perhaps take a low-dose B-complex vitamin or multivitamin with Bs if you don’t already; high doses of B-12 probably aren’t indicated).

    I am on metformin and it enabled me to achieve basically normal blood sugars. You may want to consider discussing this with a doctor with experience in the treatment of pre-diabetes and diabetes. For further general information and discussions of treatment protocols for pre-diabetes, see this site and Dr. Richard Bernstein's seminal book on the subject, Diabetes Solution.

    You should consult your doctor before taking any medication, including metformin.
    Thank you.

    I have probably read your reply half a dozen times today trying to digest everything in it. Let me first say, and I am terrible at typing, that is why I want to get it out first, THANK YOU. I appreciate the time that it took for you to give me such a detailed reply, time that you could have spent doing any number of other things. I know how long it would have taken me to type that out so I want you to know how much I appreciate your response DNFUSS.

    I was under the opinion that metformin was the worse of the two evils. I mean when a Doc says "I want you to think about going on a diabetes drug" , and your brain goes DIABETES! What the hell did you say? I kind of was in defense mode. My parents both have diabetes, but I am convinced it is because of their terrible diet, and sedentary life style. MY older brother takes metformin as a preventive measure. He is more worried about it than me. All I heard was DIABETES/Metformin. Perhaps I was to quick to jump on the Berberine wagon. I was worried about what I might take that could damage my liver, and low and behold my liver enzymes were elevated this test, after starting Berbrerine. My T is also high right now, so yeah it is never easy to pin point what the reason is.

    I have also learned about the Dawn Phenomenon, I am going to chose to believe, that is the reason is my glucose test came back elevated for me.

    I think, thanks to you, and Vince that I am going to put the Berberine aside for the time being.

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    Quote Originally Posted by blackebob View Post
    Thank you.

    I have probably read your reply half a dozen times today trying to digest everything in it. Let me first say, and I am terrible at typing, that is why I want to get it out first, THANK YOU. I appreciate the time that it took for you to give me such a detailed reply, time that you could have spent doing any number of other things. I know how long it would have taken me to type that out so I want you to know how much I appreciate your response DNFUSS.

    I was under the opinion that metformin was the worse of the two evils. I mean when a Doc says "I want you to think about going on a diabetes drug" , and your brain goes DIABETES! What the hell did you say? I kind of was in defense mode. My parents both have diabetes, but I am convinced it is because of their terrible diet, and sedentary life style. MY older brother takes metformin as a preventive measure. He is more worried about it than me. All I heard was DIABETES/Metformin. Perhaps I was to quick to jump on the Berberine wagon. I was worried about what I might take that could damage my liver, and low and behold my liver enzymes were elevated this test, after starting Berbrerine. My T is also high right now, so yeah it is never easy to pin point what the reason is.

    I have also learned about the Dawn Phenomenon, I am going to chose to believe, that is the reason is my glucose test came back elevated for me.

    I think, thanks to you, and Vince that I am going to put the Berberine aside for the time being.
    if you are on the fence about trying metformin, Nelson has a link to another post in the earlier part of this thread that will take you to an article on the benefits of taking metformin and a podcast presentation he did with Jay Campbell. They are both excellent and would be well worth your time researching. Your doctor has already offered it as an option so sounds like you can accept if you want. Let us know what you decide.

  28. #27
    Quote Originally Posted by Matt Leiser View Post
    if you are on the fence about trying metformin, Nelson has a link to another post in the earlier part of this thread that will take you to an article on the benefits of taking metformin and a podcast presentation he did with Jay Campbell. They are both excellent and would be well worth your time researching. Your doctor has already offered it as an option so sounds like you can accept if you want. Let us know what you decide.
    Thanks Matt, I will back track and watch it right now.

  29. #28
    Thanks to the very intelligent posters on here. Your generous time and efforts are appreciated.

    http://www.phlaunt.com/diabetes/14046739.php


    I feel I am getting close to being able to return to community college and get my doctorate in this stuff, okay maybe just my masters.

  30. #29
    Quote Originally Posted by blackebob View Post
    Thanks to the very intelligent posters on here. Your generous time and efforts are appreciated.

    http://www.phlaunt.com/diabetes/14046739.php


    I feel I am getting close to being able to return to community college and get my doctorate in this stuff, okay maybe just my masters.
    Glad if I was able to offer some possibly helpful information. FWIW, both of my parents were also diabetic.

    As Dr. Saya indicated above, metformin is “a good drug, as drugs go, but as with everything comes with potential side effects.” It is generally well-tolerated, the most common side effect being gastric distress, especially diarrhea (not to get too graphic, but I definitely needed to be able to access a toilet on short notice when I started on metformin). Some aver that the severity of this side effect is directly related to the amount of carbohydrates in one’s diet. I was on a quite low-carb diet and still had this side effect, so YMMV. I found symptomatic relief along with good clinical effect by switching to the extended-release formulation taken just before bed. Some swear by taking the regular formulation with meals. Again, YMMV.

    If you are reluctant to go on metformin right away, that is also understandable. Perhaps after going off berberine and a sufficient wash-out period, you could do another round of monitoring blood glucose levels as described here (note the information therein applying to low-carbers under the heading “A Special Consideration if You Have Been Eating A Low Carb Diet”). Depending on the numbers that you then see, you may decide to hold off going on metformin and instead opt for “watchful waiting” and periodic re-testing every few months. I did that for a while, but decided to go on metformin when I saw morning fasting glucose levels consistently above 100 mg/dl.

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