1. #1

    TRT: Improving RA Patient's Lives

    Men with Rheumatoid Arthritis (RA) have been shown to have a high incidence of testosterone deficiency. Low testosterone (T) can also predispose these patients to have more severe disease. Researchers at the Veteran's Administration investigated the effect of TRT on rheumatoid arthritis activity in male patients.

    Doctors prescribed a HORRIBLE TRT protocol - 200mg every eight weeks. Assessment of RA activity and treatment monitoring included: patient and physician global scores, tender and swollen joint counts, liver function tests, CBC, ESR and CRP. TRT monitoring assessments included: 30-second chair rise, 50-feet walk test, measurement of grip strength, Aging Male Symptoms (AMS) scale, as well as testosterone, prolactin, LH, and FSH measurements. Despite the inadequate protocol, patients showed marked improvement. No adverse side effects of TRT were reported.



    With TRT, 100% of patients had a decreased 50-foot walk time, 85% increased their 30-second chair rise, 92% decreased their DAS28, 50% had decreased CRP levels and 92% had decreased ESR. At 16 weeks of therapy, 50 % of patients met DAS28 remission criteria (DAS28<2.6).

    "Effect of Treatment of Hypogonadism On Rheumatoid Arthritis In Male Veterans," American College of Rheumatology Conference, https://acr.confex.com/acr/2011/webp...aper18649.html
    TIME (weeks)
    MEASURE
    (mean�SEM)
    0
    8
    16
    P value
    (0-8wks)
    P value
    (0-16wks)
    Serum T (ng/dl)
    213.4 14.2
    205 25.9
    310.9 57.5
    0.7
    0.03
    DAS28
    3.8 0.3
    2.9 0.3
    2.6 0.2
    0.0002
    0.0014
    MD-HAQ
    1.1 0.1
    1 0.1
    0.9 0.1
    0.5
    0.3
    Patient Global (mm)
    44.2 7.8
    35.1 4.8
    33.8 5.6
    0.3
    0.6
    Physician Global (mm)
    33.2 6.4
    23.7 3
    23.6 3.9
    0.15
    0.3
    ESR (mm/hr)
    29.2 5
    22.2 5
    21.9 6
    0.4
    0.017
    CRP (ng/ml)
    0.7 0.2
    0.4 0.1
    1.9 1
    0.09
    0.9
    HCT (%)
    40.0 1
    41.2 1.1
    41.1 1
    0.09
    0.1
    50-Foot Walk (secs)
    30 2
    22 2
    19.5 2
    0.0014
    0.0011
    30-sec chair (times)
    8.3 0.5
    9.1 0.5
    10.8 0.7
    0.178
    0.05
    Grip �Right (mmHg)
    55.5 6.7
    61.4 6.6
    86.07 9.0
    0.4
    0.009
    Grip �Left (mmHg)
    56 6.5
    59.4 6.4
    78.9 10.5
    0.5
    0.018
    AMS Score
    39 3.4
    31 2.4
    27.9 2.7
    0.0016
    0.0017
    I am not a physician. Comments offered here are for discussion purposes only. Please consult your doctor before initiating, changing, or stopping any therapy.

  2. # ADS
    Purchase From Our Affiliates
    Join Date
    Always
    Posts
    51
    Help Excelmale

    Defy
     

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Similar Threads

  1. Half lives of medications. Most underrated aspect of TRT
    By Gman86 in forum Testosterone Basics & Questions
    Replies: 31
    Last Post: 03-05-2018, 12:13 PM
  2. Patient Sues Doctor for Failing to monitor PSA during TRT
    By Jinzang in forum The Hang Out – Where Everything Goes!
    Replies: 1
    Last Post: 09-27-2017, 12:32 PM
  3. Younger guys: How much did TRT improve your dating lives?
    By Birdman in forum The Hang Out – Where Everything Goes!
    Replies: 1
    Last Post: 05-01-2017, 06:38 AM
  4. Younger guys: How much did TRT improve your dating lives?
    By Birdman in forum Testosterone Basics & Questions
    Replies: 1
    Last Post: 05-01-2017, 06:38 AM
  5. Replies: 4
    Last Post: 10-10-2016, 07:06 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •