SAM-E: Safe to take if on Zoloft?

Hi guys,

I'm new here and will make my intro post soon. For now I need a quick answer. I recently did a phone consult with Nelson (helpful) and he suggested take SAM-E (among other things) to help get past my depression. Is it okay to take this if I'm on Zoloft (100 mg daily)?

I've worked my way up to 400 mg/twice a day of SAM-E. Been on it for 10 days or so....but don't feel any difference.

Thanks,
NEO

If you do not feel a difference, make sure you are taking it on an empty stomach and that you are also taking it with B vitamins (low levels of several B vitamins may render SAMe ineffective). You can also go as high as 1600 mg per day

You cannot take antidepressants with it. http://www.rxlist.com/same-page3/supplements.htm

More on SAMe here: https://www.excelmale.com/forum/thr...cts-the-Liver?highlight=S-Adenosyl+methionine

What if you are injecting b vitamins will that render the sam-e ineffective?

SAMe Improves Fatigue, Depression, and Protects the Liver

Routinely prescribed in Europe for nearly 30 y, SAMe has gained popularity in the United States since its release as an over-the-counter dietary supplement in 1998–1999. Given its range of activity, SAMe has been proposed as a potential treatment for many medical conditions, particularly major depression (10). Marketed as an agent for improving mood and emotional well-being, SAMe has been featured in the national media and the popular press and has steadily attracted the attention of patients and clinicians.

SAMe is synthesized from the amino acid L-methionine through a metabolic pathway called the one-carbon cycle, which relies, in part, on adequate concentrations of the vitamins folate and B-12 (Figure 1⇑) (10, 11). Deficiencies of both of these vitamins have also been linked to depression. For example, between 10% and 30% of depressed patients may have low folate concentrations, and these patients appear to respond less well to antidepressants (12). Vitamin B-12 is converted to methylcobalamin, which is also involved in the synthesis of the various central nervous system neurotransmitters. Vitamin B-12 deficiency may result in an earlier age of onset of depression (13). The common mediator of this effect may be reduced SAMe. Correction of folate and vitamin B-12 deficiencies may alleviate depressive symptoms and augment the response to antidepressant therapy, perhaps because of the resultant increase in SAMe concentrations.

Source: http://ajcn.nutrition.org/content/76/5/1158S.full

Buy SAMe: http://www.amazon.com/Jarrow-Formul...TF8&qid=1395429120&sr=8-4&keywords=same+400mg

Brain fog..confusion my brain read this is b vits may inhibit the absorption of sam-e so sorry for the confusion.