Progesterone Question

Can you have too much progesterone? Does it hurt anything if you have levels above the reference range? I know from a previous test the reference range was 0.10 - 0.84 (ng/mL).

The only thing I can think of is if you're on an AI and have a high level of progesterone then it might bring your estrogen level to low. Could it hurt anything else?

Drawbacks of Pregnenolone Supplementation
Now, as with any hormone, there are a number of drawbacks of pregnenolone supplementation. Not everyone will experience side effects, but most users report one or more of the following:

Bloating -- Many pregnenolone users have reported feeling bloated and puffy with regular use, even when taking the hormone in tandem with DHEA or other steroid hormones. This may be due to the fact that pregnenolone increases the production of ALL sex hormones, including estradiol (the precursor to estrogen). An increase in estrogen can increase water retention, leading to bloating.

High Estrogen Levels -- As mentioned above, pregnenolone is turned into a lot of different sex hormones, including various forms of estradiol. This increase in estradiol can cause your estrogen levels to rise.

Strange Dreams -- A number of people taking pregnenolone have reported vivid, strange dreams after taking the supplement. While pregnenolone can help to reduce anxiety and stress (as we saw above), it has been known to cause your brain to be over-active when you sleep, and may lead to odd dreams.

Other Side Effects -- According to WebMD "There isn't enough information to know if pregnenolone is safe when taken by mouth." However, it has been known to cause effects similar to those resulting from other steroid hormones: arrhythmia, hair loss, facial hair growth, headaches, negative mood changes, acne, anger, anxiety, irritability, and insomnia. For those with hormone-sensitive conditions (like breast, ovarian, or uterine cancer, or endometriosis), the hormone may increase health problems thanks to the fact that pregnenolone increases the production of estrogen.

However, the truth is that these drawbacks are really fairly minimal. For the most part, pregnenolone is a fairly safe option with limited side effects. However, it's important that you understand what you're getting into when taking pregnenolone.

How Much Do You Need?

If you are considering taking to increase natural hormone production, it's vital that you know HOW MUCH to take. The last thing you want is to overdo it and end up suffering the negative side effects!

According to the experts, the optimal levels of serum pregnenolone is 180 ng/dL. If your pregnenolone is below those levels, you can look into supplements. If your levels are around that number, you may not need to take pregnenolone.

The typical dose of pregnenolone is between 50 and 200 mg per day, usually taken first thing in the morning. The pills are meant to be taken on an empty stomach, or you can use a cream (transdermal application).

However, you may want to consult with your endocrinologist before taking any pregnenolone. They may recommend a higher or lower dosage according to your pregnenolone levels, or they may counsel you against it. It's essential that you get the recommendation from a medical professional before you undergo any sort of supplement, especially hormones like pregnenolone.


https://www.discountedlabs.com/blog/post/pregnenolone-what-you-need-to-know/

thanks for the info Vince.