Resveratrol: No Impact on Metabolic Syndrome, Negatively Impacts Certain Markers

Buy Lab Tests Online

CoastWatcher

Moderator
It's known that inflammation is associated with (among other things) metabolic syndrome and obesity. Preliminary evidence suggested that resveratrol - popular/widely used as a dietary supplement - had both anti-inflammatory and positive metabolic effects and there was hope such effects could be demonstrated in a clinical/therapeutic setting.

  • A randomized, placebo-controlled, double-blind study was undertaken with the enrollment of middle-aged, community-dwelling men with metabolic syndrome into one of three groups. Average age was 49.5 years, body mass index was 33.8, and waist circumference was 115 cm.
  • Daily oral supplementation with 1000mg of resveratrol/150mg of resveratrol/placebo for 16 weeks.
  • Patient blood draws measured high-sensitivity C-reactive protein (hs-CRP), circulating lipids, inflammatory markers were sought and evaluated in circulation and adipose/muscle tissue biopsy specimens, while glucose metabolism and visceral fat deposition were evaluated as well.

Results

  • Resveratrol did not lower circulating levels of: hs-CRP, interleukin 6, or soluble urokinase plasminogen activator receptor in plasma. Inflammatory gene expression remained unchanged in adipose and muscle tissue.
  • Resveratrol had no beneficial effect on blood pressure, body composition, lipid deposition in the liver or striated muscle.
  • Resveratrol had no beneficial effect on lipid metabolism
  • Resveratrol increased total cholesterol, LDL cholesterol, and fructosamine.

Journal of Clinical Endocrinology & Metabolism, 2017 May 1.

https://www.ncbi.nlm.nih.gov/m/pubmed/28182820/
 
Defy Medical TRT clinic doctor

madman

Super Moderator
I personally believe there is a fine line regarding antioxidants as supplements as excess can be detrimental to ones health.
.
 

madhacker

Member
The Effects of Resveratrol Intake on Weight Loss: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29, 0.33), and type 2 diabetes mellitus (SMD -0.17; 95% CI, -0.37, 0.02). Overall, the current meta-analysis demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, but did not affect leptin and adiponectin levels.”

 
Buy Lab Tests Online
Defy Medical TRT clinic

Sponsors

enclomiphene
nelson vergel coaching for men
Discounted Labs
TRT in UK Balance my hormones
Testosterone books nelson vergel
Register on ExcelMale.com
Trimix HCG Offer Excelmale
Thumos USA men's mentoring and coaching
Testosterone TRT HRT Doctor Near Me

Online statistics

Members online
11
Guests online
5
Total visitors
16

Latest posts

bodybuilder test discounted labs
Top