Just got my Labs back.....

visionaire777 · Aug 26, 2017

just got my labs back,
I'm a 46 year old guy struggling with Chronic Fatigue and low libido and low energy.
i'm not taking any medication yet.
Can somebody shed some light on these results?
-----------------------------
Sex Horm Binding Glob, Serum - 118.5 H nmol/L (16.5-55.9)
Testosterone,Free and Total, Serum 411 - - ng/dL 264-916
Free and Total - Free Testosterone(Direct) - 6.2 L pg/mL ( 6.8-21.5 )
TSH - TSH 0.751 - - uIU/mL ( 0.450-4.500 )
Thyroxine (T4) Free, Direct, S T4,Free(Direct) 1.25 - - ng/dL 0.82-1.77
Luteinizing Hormone(LH), S - LH 1.9 - - mIU/mL ( 1.7-8.6 )
Estradiol, Sensitive 18.8 - pg/mL (8.0-35.0)
IGF-1 - Insulin-Like Growth Factor - 73 - - ng/mL ( 67-205 )
TgAb+Thyroglobulin,IMA or LCMS Thyroglobulin Antibody -
2.1 H IU/mL ( 0.0-0.9 )
Reverse T3, Serum - 24.2 H ng/dL (9.2-24.1)
Sex Horm Binding Glob, Serum - 118.5 H nmol/L (16.5-55.9)
Comp. Metabolic Panel (14) Glucose, Serum - 60 L mg/dL (65-99)
Iron and TIBC - Iron Bind.Cap.(TIBC) 275 - - ug/dL (250-450)
Iron and TIBC - UIBC - 98 L ug/dL (111-343)
Iron and TIBC - Iron, Serum - 177 H ug/dL (38-169)
Iron and TIBC - Iron Saturation - 64 H % (15-55)
Vitamin D, 25-Hydroxy - 33.5 - - ng/mL (30.0-100.0) .
DHEA-Sulfate 310.5 - - ug/dL (71.6-375.4)
Prolactin 8.3 - - ng/mL (4.0-15.2)
Ferritin, Serum 132 - ng/mL (30-400)
Thyroglobulin by LCMS 20.7 - ng/mL (1.4-29.2)
Cortisol 004055 Cortisol 12.4 - - ug/dL -

Vince Carter · Aug 26, 2017

Highest SHBG I think I've seen @ 118

visionaire777 · Aug 26, 2017

Vince, What does that mean ?

johndoesmith · Aug 26, 2017

visionaire777 said:
just got my labs back,
What does it mean when my

"Sex Hormone Binding Glob, Serum is way out of range at 119 on a scale of : 16.5-55.9 ?

Free and Total - Free Testosterone(Direct) - 6.2 L pg/mL ( 6.8-21.5 )

TSH - TSH 0.751 - - uIU/mL ( 0.450-4.500 )

Thyroxine (T4) Free, Direct, S T4,Free(Direct) 1.25 - - ng/dL 0.82-1.77

Luteinizing Hormone(LH), S - LH 1.9 - - mIU/mL ( 1.7-8.6 )

IGF-1 - Insulin-Like Growth Factor I 73 - - ng/mL ( 67-205 )

TgAb+Thyroglobulin,IMA or LCMS Thyroglobulin Antibody -
2.1 H IU/mL ( 0.0-0.9 )

Reverse T3, Serum - 24.2 H ng/dL (9.2-24.1)

Sex Horm Binding Glob, Serum - 118.5 H nmol/L (16.5-55.9)

Comp. Metabolic Panel (14) Glucose, Serum - 60 L mg/dL (65-99)

Iron and TIBC - Iron Bind.Cap.(TIBC) 275 - - ug/dL (250-450)
Iron and TIBC - UIBC - 98 L ug/dL (111-343)
Iron and TIBC - Iron, Serum - 177 H ug/dL (38-169)
Iron and TIBC - Iron Saturation - 64 H % (15-55)

Vitamin D, 25-Hydroxy - 33.5 - - ng/mL (30.0-100.0) .

DHEA-Sulfate 310.5 - - ug/dL (71.6-375.4)

We need more context, age, symptoms, on treatment or not(I assume you're not) and if you're taking any medications.

What was total testosterone? Did you have Estradiol tested?

CoastWatcher · Aug 26, 2017

You're going to have to provide some context for any of this to make sense. Why did you have blood drawn? What sort of symptoms were you experiencing, for how long? How old are you? What medication and supplements are you taking? Your general medical history?

You only provided your free testosterone value; what is your total testosterone? Was estradiol measured? If so, was it the sensitive, LC, MS/MS, assay?

Numbers absemt your your history and presenting symptoms are of little value. With more detail, the conversation can begin.

Blackhawk · Aug 26, 2017

SHBG binds to testosterone and estrogen rendering them pretty well otherwise useless. Your free T is low, but total T is not even shown. Total T could be quite high but free T low because of so much being bound by SHBG

Other concerns:
-Thyroid (Antibodies and elevated reverse T3)
-Hypoglycemia
-Iron

visionaire777 · Aug 26, 2017

Sorry, I'm a 46 year old guy, i'm struggling with chronic fatigue, low libido, light sleep,

CoastWatcher · Aug 26, 2017

visionaire777 said:
Sorry, I'm a 46 year old guy, i'm struggling with chronic fatigue, low libido, light sleep,

Well, your labs suggest some issues for further study.

Did you run total testosterone and estradiol? Your free testosterone suggests hypogonadism, if you will post your total testosterone it will shed more light on the subject. As was noted, your thyroid is cause for concern and further investigation.

Have you been checked for sleep apnea? Undiagnosed cases abound. It can hammer your hormones.

What else, if anything are you taking?

visionaire777 · Aug 26, 2017

Yes, i ran those too : i am not taking any medication, don't have sleep apnea,
though just had septoplasty which fixed my nasal breathing problems.

-----------------------------
Sex Horm Binding Glob, Serum - 118.5 H nmol/L (16.5-55.9)
Testosterone,Free and Total, Serum 411 - - ng/dL 264-916
Free and Total - Free Testosterone(Direct) - 6.2 L pg/mL ( 6.8-21.5 )
T4,Free (Direct) 1.25 - - ng/dL (0.82-1.77)
TSH - TSH 0.751 - - uIU/mL ( 0.450-4.500 )
Thyroxine (T4) Free, Direct, S T4,Free(Direct) 1.25 - - ng/dL 0.82-1.77
Luteinizing Hormone(LH), S - LH 1.9 - - mIU/mL ( 1.7-8.6 )
Estradiol, Sensitive 18.8 - pg/mL (8.0-35.0)
IGF-1 - Insulin-Like Growth Factor - 73 - - ng/mL ( 67-205 )
TgAb+Thyroglobulin,IMA or LCMS Thyroglobulin Antibody -
2.1 H IU/mL ( 0.0-0.9 )
Reverse T3, Serum - 24.2 H ng/dL (9.2-24.1)
Sex Horm Binding Glob, Serum - 118.5 H nmol/L (16.5-55.9)
Comp. Metabolic Panel (14) Glucose, Serum - 60 L mg/dL (65-99)
Iron and TIBC - Iron Bind.Cap.(TIBC) 275 - - ug/dL (250-450)
Iron and TIBC - UIBC - 98 L ug/dL (111-343)
Iron and TIBC - Iron, Serum - 177 H ug/dL (38-169)
Iron and TIBC - Iron Saturation - 64 H % (15-55)
Vitamin D, 25-Hydroxy - 33.5 - - ng/mL (30.0-100.0) .
DHEA-Sulfate 310.5 - - ug/dL (71.6-375.4)
Prolactin 8.3 - - ng/mL (4.0-15.2)
Ferritin, Serum 132 - ng/mL (30-400)
Thyroglobulin by LCMS 20.7 - ng/mL (1.4-29.2)

Blackhawk · Aug 26, 2017

Seems to me like plenty in that mix to get good help from a really good doc, not your average endocrinologist.

Low T
Somewhat Low E2
Thyroid concerns
Iron oddities
hypoglycemic

The SHBG number doesn't seem right in the overall context, really has me wondering if the test is skewed.

visionaire777 · Aug 26, 2017

ok thanks, really appreciate the feedback,
Do you think the guys at DEFY medical can help with this?
Who is the best doctor in the US who can help with this ?

CoastWatcher · Aug 26, 2017

visionaire777 said:
ok thanks, really appreciate the feedback,
Do you think the guys at DEFY medical can help with this?
Who is the best doctor in the US who can help with this ?

The doctors at Defy would be able to deal with this, I've no doubt. You'd receive fine are with them.

Blackhawk · Aug 26, 2017

visionaire777 said:
Do you think the guys at DEFY medical can help with this?
Who is the best doctor in the US who can help with this ?

Yes,

Don't know about best in the US but I really like Dr Saya.

madman · Aug 26, 2017

visionaire777 said:
just got my labs back,
I'm a 46 year old guy struggling with Chronic Fatigue and low libido and low energy.
i'm not taking any medication yet.
Can somebody shed some light on these results?
-----------------------------
Sex Horm Binding Glob, Serum - 118.5 H nmol/L (16.5-55.9)
Testosterone,Free and Total, Serum 411 - - ng/dL 264-916
Free and Total - Free Testosterone(Direct) - 6.2 L pg/mL ( 6.8-21.5 )
TSH - TSH 0.751 - - uIU/mL ( 0.450-4.500 )
Thyroxine (T4) Free, Direct, S T4,Free(Direct) 1.25 - - ng/dL 0.82-1.77
Luteinizing Hormone(LH), S - LH 1.9 - - mIU/mL ( 1.7-8.6 )
Estradiol, Sensitive 18.8 - pg/mL (8.0-35.0)
IGF-1 - Insulin-Like Growth Factor - 73 - - ng/mL ( 67-205 )
TgAb+Thyroglobulin,IMA or LCMS Thyroglobulin Antibody -
2.1 H IU/mL ( 0.0-0.9 )
Reverse T3, Serum - 24.2 H ng/dL (9.2-24.1)
Sex Horm Binding Glob, Serum - 118.5 H nmol/L (16.5-55.9)
Comp. Metabolic Panel (14) Glucose, Serum - 60 L mg/dL (65-99)
Iron and TIBC - Iron Bind.Cap.(TIBC) 275 - - ug/dL (250-450)
Iron and TIBC - UIBC - 98 L ug/dL (111-343)
Iron and TIBC - Iron, Serum - 177 H ug/dL (38-169)
Iron and TIBC - Iron Saturation - 64 H % (15-55)
Vitamin D, 25-Hydroxy - 33.5 - - ng/mL (30.0-100.0) .
DHEA-Sulfate 310.5 - - ug/dL (71.6-375.4)
Prolactin 8.3 - - ng/mL (4.0-15.2)
Ferritin, Serum 132 - ng/mL (30-400)
Thyroglobulin by LCMS 20.7 - ng/mL (1.4-29.2)
Cortisol 004055 Cortisol 12.4 - - ug/dL -

You did list total t in your first post but it is written incorrectly as you typed Testosterone, Free and Total, Serum 411 ng/dL 264-916

Vitamin_C · Aug 29, 2017

that SHBG tho....

visionaire777 · Aug 29, 2017

what does that mean that my SHBG is super high ?

Systemlord · Aug 29, 2017

visionaire777 said:
what does that mean that my SHBG is super high ?

I've never seen SHBG quite that high before, you should be concerned! You need to tell us about your lifestyle, diet, drinking alcohol, body weight and height, exercise etc. Labs only tell us part of the story.

https://naturalbiohealth.com/2015/05/06/shbg-critical-to-your-health/

visionaire777 · Aug 29, 2017

don't drink or smoke, eat a Paleo style diet, lots of Veggies and Good Meats.
46 years old, 5'11 / . 165 lbs. / . live a healthy lifestyle.

lexer · Aug 29, 2017

You have low free test and low LH. This is what you see from former steroid users. Did you ever use steroids or testosterone? Are you obverweight?

visionaire777 · Aug 30, 2017

no, to both of those. never used steroids, not overweight,

Just got my Labs back.....

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