Prostate Cancer: Can Biomarkers Make a Treatment Difference?

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CoastWatcher

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Many men, far too many, will be diagnosed with prostate cancer. At this point in time, there are four variables that determine treatment response: patient age, tumour size, pre-treatment PSA level, and Gleason score. Most urologists will admit that these are (at best) imperfect guides for physician and patient both. Researchers are currently looking at six, prognostic biomarkers that it is hoped will identify those patients at risk for aggressive prostate cancer, or the recurrence of prostate cancer, following treatment.

A study in France analyzed all available data for these biomarkers: PHI, 4Kscore, MiPS, GPS, Prolaris, Decipher. Would these biomarkers help doctors know who, when diagnosed with prostate cancer, could best be served by:

  • A first or second biopsy
  • Active surveillance/watchful waiting
  • Radical prostatectomy
  • Adjuvant treatment

Two of the biomarkers, PHI and 4Kscore, had the highest level of evidence for predicting aggressive prostate cancer. The other four showed potential for helping guide clinical decision making, but call for greater study.


We continue to see that progress in the battle against prostate cancer may be steady, but is still very slow.


https://www.ncbi.nlm.nih.gov/pubmed/28753865
https://www.urotoday.com/recent-abs...te-cancer-management-a-systematic-review.html
 
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