1. #1

    High Estradiol - Do I Need Anastrozole?

    Hi, my endo finally agreed to test my estradiol levels, and I got 50pg/dl when the range is like 0-40. But he said it is marginally high and refused to prescribe anaztrozole saying that may cause heart attacks and there is no studies about it.

    I am on a TRT only protocol 100mg/week and after a few months of feeling great and having high libido, it all came back to original state.

    My testosteroen and free T came ok so I suspect estradiol is to blame into this.

    I feel like I need to lower my estradiol, any idea which doctor wouold agree to prescibe anaztrozole, do I have higher changes with a primary care physician, an urologyst or another endo?

    I am planning to go into a Mens clinic, but cannot do it this year due to budget.

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  3. #2
    Was that the sensitive E2 test? I ask because all too often regular docs prescribe the wrong test that often (not always, but most of the time) shows a higher level than what you actually have.

    What about other blood work? Post what you have as it will help with the discussion.

  4. #3
    Quote Originally Posted by ERO View Post
    Was that the sensitive E2 test? I ask because all too often regular docs prescribe the wrong test that often (not always, but most of the time) shows a higher level than what you actually have.

    What about other blood work? Post what you have as it will help with the discussion.
    Indeed good call...blood work will generate some discussion, as the wrong test will take you in the wrong direction and on the surface 50 really isnt that high that you need to approach it as a must reduce.

  5. #4
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    Thanks Guys. My protocol is 100mg shots weekly of Depo Testosterone Cypionate.

    On day 3 after the shot:
    Total T 856 ng/dl
    Free T 256 ng/dl
    SHBG 19 nmol/L
    Free T % 3.0%

    On day 7 (just before next shot)
    Total T 445 ng/dl
    Free T 126 ng/dl
    SHBG 17 nmol/L
    Free T % 2.8%

    Estradiol 50pg/ml (not sensitive though) This was a test a week after the above!

    However, I have been feeling like crap for almost 3 weeks, and it I was agradual decline.

    At first, everything was ok
    then, just the first 3 days
    then, the first 2 days
    the next one, just 1 day
    and the very last one I had the shot and felt absolutely 0% difference in sex drive and energy.

    And that was the week of testing. It does not make sense that even having it relatively high for 2-3 days or so, and I did feel 0 libido, etc.

    Can anybody help to see what else could it be? My endo gave up, but did not want to raise my T dose or give me anastrozole.

  6. #5
    Moderator Vince's Avatar
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    Estradiol 50pg/ml (not sensitive though) without knowing your true estradiol levels, you shouldn't consider taking an AI. I would get the right test first.
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

  7. #6
    You are injecting once weekly. That, in and of itself, may be contributing to an estradiol problem, if, indeed, that's at the root of your issues (and you don't know since you were given the wrong test). Why have you and your doctor not split that dose into twice weekly injections? Your SHBG is low...smaller, more frequent injections might well solve your problems. Your protocol is working against you.
    I am not a physician. Comments offered here are for discussion purposes only. Please consult your doctor before initiating, changing, or stopping any therapy.

  8. #7
    I agree totally, poorly designed protocol for you the individual.

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