E2 Under Five - What More Can I Do to Boost It?

Dr Justin Saya MD · May 5, 2017

Transdermal testosterone, especially when applied over a section of the body with a significant fat layer, will typically raise estradiol more than any other modality.

Tammysguy · May 5, 2017

Here is the actual result from Discountedlabs, just to show the evidence. I talked to my doc today. She wants to increase my HCG to 1500 ius. She believes more of this will convert to estrogen. I guess we will find out what happens. I know the risk of this approach is leydig cell desensitization.

The DHEA I have been taking is oral, just a supplement from Swanson Health.

I used a cream before getting shots and had a hard time getting my levels up. If the HCG doesn't work, I will talk to my doctor. I don't know if it would be possible to reduce my testosterone injections and get some of my testosterone from transdermal. I really don't want to go the transdermal route again, but if my e2 doesn't go up, I may have to. Thanks for replying, Dr Saya.

I also take Metformin, 500 mgs at dinner. I take synthroid daily. Lunesta a few nights each week. I don't know if any of these would cause issues.

Dr Justin Saya MD · May 5, 2017

Tammysguy said:
I don't know if it would be possible to reduce my testosterone injections and get some of my testosterone from transdermal. I really don't want to go the transdermal route again, but if my e2 doesn't go up, I may have to. Thanks for replying, Dr Saya.

Yes, augmenting your base injectable regimen with a transdermal would be a nice approach in this scenario.

johndoesmith · May 6, 2017

CoastWatcher said:
https://www.excelmale.com/forum/sho...entation-in-Elderly-Men-A-Meta-Analysis-Study

As Nelson points out, this meta-analysis indicates that estradiol rises in the presence of DHEA in most placebo-controlled studies as of the date of this effort.

Hmm, certainly seems like there's some evidence DHEA increases estradiol in men, but it seems 50/50 in terms of DHEA causing a significant increase and DHEA not causing any increase in E2 in men.

Although this was interesting.

DHEA supplementation did not improve any of the sexual function outcomes evaluated, including overall score of International Index of Erectile Function (IIEF) total score (IIEF-15), IIEF-erectile function domain score, and sexual desire

No additional effect of DHEA supplementation on several other outcomes, including metabolic profile, bone health, sexual function, and QOL, was observed.

So there's just as much evidence that it increases E2 as there is that DHEA does not increase E2. Like most things in hormonal research, the jury is still out.

E2 Under Five - What More Can I Do to Boost It?

Dr Justin Saya MD

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