Oral contraceptives may lower general well-being in healthy women

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Nelson Vergel

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Treatment with the oral contraceptive reduced the global score of the Psychological General Well-Being Index compared with placebo (–4.12; P = .0085). Positive well-being (P = .0492), self-control (P = .0046) and vitality (P = .008) were also negatively affected by oral contraceptives compared with placebo. No difference was found between the oral contraceptive and placebo groups for anxiety, depressed mood or general health. Similarly, researchers observed no significant differences between the two groups for the Beck Depression Inventory.
At baseline, 35% of all participants had moderate to severe distress in general well-being and 7% had moderate to severe depressive symptoms. After treatment, the oral contraceptive group had higher moderate to severe distress in general well-being (44%) compared with the placebo group (38%). No difference was found for moderate to severe depressive symptoms (7% for both).

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