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    ‘Bioidentical’ hormone capsule reduces hot flushes in menopausal women

    An investigational combination of 17beta-estradiol and progesterone appears to be safe and effective for reducing hot flash frequency and severity in menopausal women, according to results of the REPLENISH trial.

    No cases of endometrial hyperplasia or endometrial cancer were observed among any of the groups. Consensus reads of active and disordered hyperplasia at 12 months were identified in 2.9% of the 1 mg/100 mg group, 1.7% of the 0.5 mg/100 mg group, 0.3% of the 5 mg/50 mg group, 1.1% of the 0.25 mg/50 mg group, and none of the placebo group.

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