E2 levels for low SHBG guys

I think that this is the area for low SHBG guys...free Estrogen. Thanks for following along SystemLord

Systemlord said:

Excellent thread! This free E2 test might just be what I need to get dialed in as I'm currently battling high E2 do to my somewhat low SHBG (18-20). I've also heard Dr. Crisler mention that if a guy has SHBG of 20 that having a similar score for E2 could mean it's to high for him do to the free E2 being high relative to his E2.

I'm going to concentrate on free numbers rather than total numbers from now on.

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Systemlord, do I understand it that you're working the E lowering by lowering your daily Cyp dose and that you're not using an AI? I read another thread I think 20mg/D Cyp for you?

Vince Carter said:

Systemlord, do I understand it that you're working the E lowering by lowering your daily Cyp dose and that you're not using an AI? I read another thread I think 20mg/D Cyp for you?

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I started 17.5mg EOD no AI a few days ago and symptoms are disappearing fast, if I can get to the 600-700 range without an AI then great. I'm going to attempt to lose 50-70 pounds then attempt a dose increase without an AI and see how my body converts T to E2, I've read guys who are in good shape physically are the ones who need either no AI or very little. At 20mg EOD I felt as if I was right on the line or barely past the point where E2 starts becoming an issue.

Systemlord said:

I'm going to attempt to lose 50-70 pounds then attempt a dose increase without an AI and see how my body converts T to E2, I've read guys who are in good shape physically are the ones who need either no AI or very little.

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The visceral fat -> aromatase ->E2 -> more visceral feedback loop is vicious. As far as I am concerned, visceral fat is evil.

Systemlord said:

I started 17.5mg EOD no AI a few days ago and symptoms are disappearing fast, if I can get to the 600-700 range without an AI then great. I'm going to attempt to lose 50-70 pounds then attempt a dose increase without an AI and see how my body converts T to E2, I've read guys who are in good shape physically are the ones who need either no AI or very little. At 20mg EOD I felt as if I was right on the line or barely past the point where E2 starts becoming an issue.

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I wish you great success in regard to your weight-loss goal. In many cases you're right, low body fat can minimize the need for an AI. Some men, though, no matter what efforts they undertake, need in. Either way, the loss of the weight will improve your health. Good luck.

Anecdotally, an increase to appx .35mg EOD has resulted in some increased sensitivity and a substantial increase in orgasm intensity, libido is slightly increased. I am opening a .25mg and trying to divide the contents in half so what I'm doing is .25mg plus half (~12.5mg) from a second capsule. No changes to Cyp dose.

Vince, do you carry much body fat? Or no? Thanks, just curious.

No, but more thank I'd like be in bodyfat, though I've been "bulking" lately...5' 9" 225lbs

Looking good! Was just wondering because you seem to need a lot of the AI. .25mg EOD would put me way too low.

I aromatase like crazy for no known reason ive gone all the way down to Cyp only and still have sky high e2 with TT in the 1000-1100, but of course low SHBG means my free T is astronomically high

Systemlord said:

Excellent thread! This free E2 test might just be what I need to get dialed in as I'm currently battling high E2 do to my somewhat low SHBG (18-20). I've also heard Dr. Crisler mention that if a guy has SHBG of 20 that having a similar score for E2 could mean it's to high for him do to the free E2 being high relative to his E2.

I'm going to concentrate on free numbers rather than total numbers from now on.

Click to expand...

Second or third time I think I'm seeing this SHBG value being very close to E2. I'm working a Cyp dose reduction by 4mg/D (42mg drop per week) to see if my Free T will come down and translate to less aromatase/E2/Free E. I have labs in about 10days. I would have to take more AI to get my LC/MS/MS down from 42 which isn't my preferred way of doing it right now, I think .25mg is enough without trying a Cyp dose reduction.

My symptoms of fatigue, weakness, depression, ed, blurry vision sometimes, difficulties walking etc.. have been undiagnosed for a year now.
Have had so many blood tests.
Only thing left really is E2 and Free E2 as the cause I believe on the endocrine side.
My total t was 777(250-940), Free t was 25.6(5-15.6), estrodial was 42(8-42.6). I had shgb tested a few years ago and it was 22(10-61).
I’ve lowered my cypionate dose from 80mg every 5 days to 60mg every 5 days 1 week ago. The 60 mg dose worked great for 3 years symptom wise. When we moved up to 80 mg l felt really good for about 2-3 months and then had very gradual negative symptoms to get to where I am now feeling aweful.
Is there anyway that my numbers and dose changes could be it? This is probably my last endo chance otherwise it’ll be a neurological thing I’m figuring. It’s been only a week and don’t feel any better. Any chance my symptoms could correlate with this?
Thanks

Thought I'd resurrect this one with an update, I'm doing as well as any othertime I suppose, nothing at negative to say about my numbers below, no negative sides, doing quite well but still trying to resolve sexual issues. Penile sensitivity has glimmers of being better, still using Cialis/Viagra with good results. Body acne is getting better but still requires diligent prevention/washing, temperment and mood is still a little iffy. Based on all these things I reduced Cyp to 12mg/D.



At 16mg/D, labs:

16mg/D
200iu HCG once per week
.25mg AI EOD

LC/MS/MS: 18 (<=29)
Estradiol: 23 (<=29)
Estradiol, Free: .62 (<=0.45)
TT: 941 (250-1100)
FT: 291 (35-155)
PSA: 0.6

Vince Carter said:

Thought I'd resurrect this one with an update, I'm doing as well as any othertime I suppose, nothing at negative to say about my numbers below, no negative sides, doing quite well but still trying to resolve sexual issues. Penile sensitivity has glimmers of being better, still using Cialis/Viagra with good results. Body acne is getting better but still requires diligent prevention/washing, temperment and mood is still a little iffy. Based on all these things I reduced Cyp to 12mg/D.



At 16mg/D, labs:

16mg/D
200iu HCG once per week
.25mg AI EOD

LC/MS/MS: 18 (<=29)
Estradiol: 23 (<=29)
Estradiol, Free: .62 (<=0.45)
TT: 941 (250-1100)
FT: 291 (35-155)
PSA: 0.6

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You like your e2 that low?

Vince Carter what is the reason for you being on trt? if you are looking after sexual improvements you might have more success with letting your body producing testosterone naturally even if it's low a lot of folks don't have any sexual problems with low T it's mostly fatigue, not being able to build big muscle, get stronger and stuff like that.. it's one of the reasons i quit trt because I started to have less and less erections on it and less libido maybe has something to do with lack of LH I am not sure
i feel my sex life is better with natural testo but overall quality of life is better on trt (more motivation, stronger, better physique, more energy)
are you still on AI?

35 posts in two pages is a lot to ask someone to read, I know.

Vince Carter said:

Thought I'd resurrect this one with an update, I'm doing as well as any othertime I suppose, nothing at negative to say about my numbers below, no negative sides, doing quite well but still trying to resolve sexual issues. Penile sensitivity has glimmers of being better, still using Cialis/Viagra with good results. Body acne is getting better but still requires diligent prevention/washing, temperment and mood is still a little iffy. Based on all these things I reduced Cyp to 12mg/D.



At 16mg/D, labs:

16mg/D
200iu HCG once per week
.25mg AI EOD

LC/MS/MS: 18 (<=29)
Estradiol: 23 (<=29)
Estradiol, Free: .62 (<=0.45)
TT: 941 (250-1100)
FT: 291 (35-155)
PSA: 0.6

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How is your hematocrit doing with lower dosage?

Are you going to reduce your AI dose too since you’re dropping your test dose?

Also how are your testicles doing on the low dose of HCG? How’s your ejaculate volume? And how does your testicles look compared to a higher dose? I’d like to lower my HCG dose to lower E2 a little, but am worried about testicular atrophy obviously.

The way things look to me is I'll always need the AI, which I could care less about, not doing this to get off the AI, of control my HCT. If I regain the sensitivity and Erection quality then I win all the way around in my book. Sensitivity is noticeable better. I'm tired of a few other things than an AI or HCT.

Scrotum subjectively comparing overtime is much looser and lower with my E knocked down this far. I still think HCG does nothing for me beyond the outward appearance or cosmetic look of everything. My GF likes it. Ejaculate is unchanged over time, never been a "shooter", ever, and can barely hit the floor if I aim it straight down. No complaint, just my normal.

Labs on 6 Jul @ 12mg/D

I assume u've done higher doses of HCG in the past. Have you noticed that your testicles are noticeably smaller while on the small dose of 200iu/ week? Or no difference really?