Cortisol Regulation (an Overview)

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Nelson Vergel

Founder, ExcelMale.com
By James Wilson, DC, ND, PhD



Cortisol is responsible for many life-sustaining functions. Although cortisol is secreted by the zona fasciculata in the adrenal glands, it is regulated primarily by the brain. The amount of cortisol circulating at any particular moment is regulated by a complex interaction between the hypothalamus, the pituitary gland, and the adrenal glands. This regulatory trio, often referred to as the HPA axis, operates through a negative feedback system.

The Negative Feedback System
A negative feedback system works like the thermostat in a house or apartment. The thermostat senses the heat in the room and compares it with the desired temperature at which it has been set. When the heat gets too low, the thermostat signals the relay switch to tell the furnace to ignite, sending out hot air into the room and raising the heat. When the heat has risen to the desired level, the thermostat signals the furnace to quit until more heat is needed. This cycle is called a negative feedback system because when enough heat is released, a negative signal is sent to slow or stop the input.

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