Vitamin K is associated with a reduced risk of cardiovascular, cancer, or all-cause mortality

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Vince

Super Moderator
Intake of menaquinone was inversely related to all-cause mortality . https://www.ncbi.nlm.nih.gov/pubmed/15514282
.
Increase in dietary intake of vitamin K is associated with a reduced risk of cardiovascular, cancer, or all-cause mortality in a Mediterranean population at high cardiovascular disease risk.
http://jn.nutrition.org/content/144/5/743
.
Clinical Nutrition has published a new long-term study that explores if there is a relationship between intake of phylloquinone and menaquinones (vitamins K1 and K2, respectively) and all-cause and cause-specific mortality. The results showed that high intake of menaquinones (vitamin K2) was associated with a reduced risk of CHD (coronary heart disease) (at least in hypertensive participants), while high intake of phylloquinone (vitamin K1) was not associated with any reduced risks.
Vitamin K intake was not associated with all-cause mortality, cancer mortality and mortality from other causes.

http://www.clinicalnutritionjournal.com/article/S0261-5614(16)30216-3/abstract

http://www.bodyscience.com.au/blog/...-shown-again-to-impact-cardiovascular-health/
 
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Gene Devine

Super Moderator
Vit K is an amazing vitamin in soooo many ways. You need it if you're supplementing calcium or else calcium will just stay in serum and never synthesize into bone density.

I take it religiously.

Also is huge in blood clotting factors...which is great for women who bruise easily.
 

rhino5169

Member
I just re read what I wrote. I guess I was tired so it didn't come out right.
Vitamin K reduces the effect of plavix. If you're taking plavix I think it's pretty important that it's doing its job.
 

Vince

Super Moderator
Plavix is a drug that thins the blood by reducing platelet aggregation. It has nothing to do with vitamin K. Warfarin/coumadin is a blood thinner that works by reducing vitamin K recycling in the liver, which reduces production of the vitamin K dependent proteins that make blood coagulate. Vitamin K supplements do not affect the action of plavix, aspirin, or other platelet aggregation reducing medications. They do affect the action of vitamin K antagonists like warfarin/coumadin.
 

rhino5169

Member
Vitamin K & Plavix. ... Some vitamins may interfere or enhance the effects of medications. Plavix, for example, is a prescription medication that affects blood clotting and taking vitamin K, a vitamin necessary for blood to clot, may affect the biological activity of Plavix.


"Medications classified as anticoagulants, such as warfarin, act directly on vitamin K within the body to prevent the formation of blood clots. Although Plavix, classified as an antiplatelet medication, does not directly interact with vitamin K to prevent the formation of blood clots, you should avoid large fluctuations in vitamin K intake while taking any medication to treat clotting disorders. "
http://www.livestrong.com/article/459092-vitamin-k-plavix/


 

Vince

Super Moderator
Think of it this way: Vitamin K1 (not K2) allows normal coagulation. Plavix blocks (an aspect of) platelet function.
In other words, the K1/K2 do not counteract the platelet-blocking effect of Plavix.
 

Gianluca

Well-Known Member
Vitamin K increase clotting, how about TRT and elevated H&H and the intake of supplemental vit K? I understand the benefits but it scares me to increse the chance to get a blood clot for high HH
 

Vince

Super Moderator
The improvement in insulin sensitivity due to vitamin K2 intake is important. Excess insulin contributes to the formation of soft arterial plaque.
We know that The vitamin K-dependent matrix Gla-protein (MGP) is a potent inhibitor of arterial calcification.
https://www.ncbi.nlm.nih.gov/pubmed/18841280
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555157/
https://www.ncbi.nlm.nih.gov/pubmed/9052783?
Coronary plaque on average is about 20% calcified and 80% non-calcified but some people have plaque which is 100% non-calcified.


 

rhino5169

Member
Interesting.
When you say calcified do you mean hardened areas of plaque on the arterial walls?
If so, my dr wants me to be on a statin not so much for the lipid benefits but he says that it will harden any soft deposits, and that when they are soft there is a chance of rupture causing heart attack or stroke.
 

Vince

Super Moderator
I agree, that calcified plaque is stable plaque, less chance of rupturing and causing a heart attack or stroke.
 

rhino5169

Member
He wants me on 20mg pravastatin.
I've been reluctant because in the last 1.5 years i've been able to get myself off all past meds - 4 insulin shots a day, metformin, lipitor, ramipril, aspirin, to name a few.

I dont want to go back to any meds if possible, but im rethinking the pravastatin, just dont want to deal with the sides.
 

Vince

Super Moderator
He wants me on 20mg pravastatin.
I've been reluctant because in the last 1.5 years i've been able to get myself off all past meds - 4 insulin shots a day, metformin, lipitor, ramipril, aspirin, to name a few.

I dont want to go back to any meds if possible, but im rethinking the pravastatin, just dont want to deal with the sides.


do you have a plaque score, the doctors I see will only put you on a statin if you have plaque
 

Vince

Super Moderator
CT heart scan to check plaque, if you have artery stents. You can't have a CT scan to check artery plaque, stents block image. It sounds like you need a statin, only my opinion.
 

rhino5169

Member
CT heart scan to check plaque, if you have artery stents. You can't have a CT scan to check artery plaque, stents block image. It sounds like you need a statin, only my opinion.

Thanks Vince.
I've been on the fence but have been leaning towards giving it a go but keeping an eye for side effects. I dont want to take a step backwards, but i'd also rather not have a heart attack.

Opinion on Vit K2 even though I have stents and am on Plavix?
 

rhino5169

Member
I keep seeing things like this:

"- Blood thinners. Vitamin K reduces the effectiveness of blood thinning medications and should not be taken if you are on a medication like Coumadin (warfarin) or Plavix."
 

Gianluca

Well-Known Member
from my research, blood thinners work by blocking vit K so that the blood becomes thin, in the other hand blocking Vit K will result in plaque deposit in the arteries, I read this from Lifextention....

I keep seeing things like this:

"- Blood thinners. Vitamin K reduces the effectiveness of blood thinning medications and should not be taken if you are on a medication like Coumadin (warfarin) or Plavix."
 
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