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Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay
Even with secondary hypogonadism you could give small enough doses of testosterone cypionate such that LH would not go to zero. However, the contrast is that with secondary the brain is calling its low testosterone level "normal", so any exogenous testosterone immediately works to suppress the...- Cataceous
- Post #29
- Forum: Testosterone and Men's Health Articles
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Shallow Testosterone IM versus SubQ Injections - Lab Results
Any rigorous evidence for this? Until then I'll go by the studies measuring areas-under-the-curve, which do not find a difference between SC and IM. I don't discount that differing absorption rates can affect other parameters, but I remain skeptical of the disappearing-testosterone hypothesis.- Cataceous
- Post #109
- Forum: Testosterone Basics & Questions
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Gel vs injection
I would reject the claim that gels are more physiological than injections. In some cases the diurnal rhythm in serum testosterone is more natural looking. But I think this is outweighed by DHT levels that are often not physiological. Even when DHT is in range it may be relatively large compared...- Cataceous
- Post #3
- Forum: Testosterone Side Effect Management
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Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay
In fact these more complicated techniques are better suited for treating secondary hypogonadism. With short-acting testosterone the troughs in serum testosterone are low enough and long enough that even the overly-sensitive HPTA experiences less suppression. Meanwhile, the peaks to mid- or...- Cataceous
- Post #27
- Forum: Testosterone and Men's Health Articles
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Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay
No, it can be much simpler than that. I believe it's sufficient to provide a fixed background level of testosterone. Then the HPTA can handle the rest with its natural variations. As a simple example, suppose a guy would normally have morning testosterone of 600 ng/dL, but develops testicular...- Cataceous
- Post #23
- Forum: Testosterone and Men's Health Articles
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Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay
There were a couple guys on the old PeakTestosterone forum successfully using this approach. With primary hypogonadism the HPTA feedback mechanisms are largely intact; the brain is calling for a healthy amount of testosterone, but the testicles cannot respond adequately. Therefore it is possible...- Cataceous
- Post #21
- Forum: Testosterone and Men's Health Articles
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Concerned about hair loss: TRT + deca vs TRT alone vs deca alone
A conservative approach that should promote your goals: use a short-acting form of testosterone; switch to topical finasteride and/or dutasteride; use ibutamoren if IGF-1 is below average. Short-acting forms of testosterone include nasal gels, buccal troches and micronized testosterone...- Cataceous
- Post #6
- Forum: Testosterone Side Effect Management
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Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay
One good thing about primary hypogonadism is that testosterone (augmentation) therapy is relatively low risk if you adopt a low-and-slow approach and titrate to achieve normal LH and FSH. In this case you can achieve supplementation without replacement; your HPTA feedback loop keeps operating...- Cataceous
- Post #17
- Forum: Testosterone and Men's Health Articles
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Is Fiber Really Essential?
Grok to the rescue: Direct Answer Research suggests a high-fiber diet likely improves health, with strong evidence for benefits like better digestion, heart health, and blood sugar control. The evidence leans toward reduced risks of heart disease, type 2 diabetes, and certain cancers, though...- Cataceous
- Post #4
- Forum: Nutrition and Supplements
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Where to buy peptides?
Assuming you're in the United States: Many of these peptides are not FDA approved and cannot legally be sold for human use. With respect to the ones that are approved, they generally require a prescription and must be made at approved facilities. All of this regulation is bypassed when the...- Cataceous
- Post #2
- Forum: General Peptide Use & Information
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High Testosterone, is this expected?
This is not too unusual. There's at least one study finding absorption via scrotal skin to be over 50%. Consider that healthy young men typically produce 6-7 mg of testosterone daily. You're potentially getting into the realm of four times that with your two doses. It's different at other...- Cataceous
- Post #2
- Forum: Blood Test Discussion
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Starting TRT Soon
Not above average, above range. This means more than two standard deviations above average. In general there are all kinds of negative associations when hormones are out of range, not least of which is reduced longevity. Although long-term research is lacking, specific to testosterone there are...- Cataceous
- Post #41
- Forum: Testosterone Basics & Questions
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Starting TRT Soon
It's the opposite. The majority should not be dosed excessively just because the more-is-better minority is louder and more demanding. No, it isn't. It makes no sense to start TRT at a dose that is effectively above the physiological production range. Even the recommended starting dose for...- Cataceous
- Post #38
- Forum: Testosterone Basics & Questions
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enclomiphone lowered my testosterone
Throwing out a couple possibilities: Your SHBG dropped between the measurements, such that an increase in free testosterone was concealed. Or you actually have primary hypogonadism, i.e. testicular insufficiency. Have you tested LH?- Cataceous
- Post #2
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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