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Defy Medical TRT clinic doctor
  1. C

    [urgent help] battling long long term effect of enclo

    Though it might be too subtle to make a dent in such an extreme sleep disturbance, one thing you could try is measuring your serum progesterone, and if it's at the lower end of the range then supplement with some each night. Progesterone naturally opposes estradiol and is somewhat of a sleep aid...
  2. C

    TRT Peaks and troughs or steady levels. Which is correct?

    I'm not aware of anything new on the subject. The successes of testosterone nasal gel and oral testosterone seem likely to reduce interest in finding ways to more precisely mimic a normal diurnal rhythm in serum testosterone. You may have seen a study referenced by @madman showing that a...
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    Aging and Testosterone dose

    If one is looking to maintain free testosterone at a particular level then it's typical to need dose reductions over time. This is because the metabolic clearance rate of testosterone tends to decrease with age, which in turn increases free testosterone, as mentioned here. It's harder to...
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    TRT Peaks and troughs or steady levels. Which is correct?

    It's a good question, without a definitive answer. There's too much individual variation to say whether you'd find the differences to be subtle or profound. Neither modality produces a natural-looking diurnal rhythm in serum testosterone. However, men can have good results with either...
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    What affects free testosterone under TRT?

    Tempting though it is to veer into some caustic remarks, let's stick to the facts. Are your previous posts based on your understanding of the subject or are they AI generated? If the latter then which AI and which inputs?—And why didn't you disclose AI use at the time? Why don't you or the AI...
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    What affects free testosterone under TRT?

    The reasoning is incorrect and contradicts what is set out in the original post. A drop in SHBG only transiently affects free testosterone. At the new steady state free testosterone returns to its previous value, which is tied only to the testosterone production/dose rate and the clearance rate...
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    Bromantane experiences ?

    No, but it sounds interesting. For me, caffeine has more cons than pros, so it would be nice to have an alternative. I might get some bromantane to try next time I place an order with NS.
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    Bromantane experiences ?

    I see that Nootropic Source has the powdered form—in case anyone is looking for a pretty reliable source. A dosing summary from Grok: Typical oral doses for bromantane powder range from 50–100 mg per day, often taken once in the morning to avoid potential insomnia. A lower starting dose of 25...
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    About to Start a New Protocol

    It's actually neither, though the former—the thin, permeable skin—increases absorption efficiency. It's the prevalence of 5-alpha reductase in the scrotal skin that boosts production of DHT. There can also be a fair bit of aromatase, boosting estradiol as well in many cases. The testes don't...
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    Enclomiphene Pharmacy Options

    Defy Medical was using Taylor Made for enclomiphene until they eventually switched to Empower. The product from both of these places seemed to do the job. As I recall, Taylor Made at one time was having some legal issues, but maybe nothing affecting product quality. I'd say Empower is a slightly...
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    Hypo since 20 y/o - now 30. Thoughts on this bloodwork?

    There are pros and cons to either. Enclomiphene blocks the negative feedback from estradiol, which stimulates the HPTA. The higher LH/FSH then lead to increased testosterone, at least if the testicles are functioning well. Enclomiphene has the advantage of stimulating the entire HPTA. Clinical...
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    Hypo since 20 y/o - now 30. Thoughts on this bloodwork?

    Ok, that confirms the previous number and an unusual pattern. You seem to have bounced back from the first episode in 2016 after dabbling with Clomid and hCG. Possibly you could again. As mentioned above, enclomiphene is usually preferred over Clomid. If you don't get acceptable results with...
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    Hypo since 20 y/o - now 30. Thoughts on this bloodwork?

    You really needed a testosterone measurement to go with that LH/FSH. With the huge variability in your readings I wouldn't trust that it remained at the 91 ng/dL from August, even if that value was correct. There is still uncertainty. No, this combination points to secondary, where the brain...
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    Thoughts / Advice on bloodwork

    I was curious what AI would say about cabergoline vs P5P: Effectiveness Cabergoline is generally more effective for lowering prolactin levels, particularly in cases of hyperprolactinemia in men, such as those caused by prolactinomas. Multiple studies show it can normalize prolactin levels and...
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    Thinking about TRT and could use some guidance

    There are better options than conventional TRT. First, strongly consider switching to topical finasteride. The side effects profile is considerably improved, reducing your risks in the long run. If you still feel as though there's a lot of room for improvement then try a fast-acting testosterone...
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    Thoughts / Advice on bloodwork

    With the caveat that your results are hard to read due to low resolution, it appears that Vermeulen calculated free testosterone is about 11 ng/dL. This is not really into hypogonadal territory. On the other hand, having prolactin near top-of-range can be problematic. If your health and...
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    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    It's still a small enough molecule that you might have reasonable absorption—but "reasonable" is only about 10%, so it's not very efficient. Possibly better if applied to the scrotum. If there is such a thing then you'd want to think about possible side effects; 5ar does more than convert T to...
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    Hypo since 20 y/o - now 30. Thoughts on this bloodwork?

    Your 2016 and 2021 results are contradictory. It seems unusual to move from secondary hypogonadism to the edge of primary and back. Another interpretation is that you've always had borderline testicular insufficiency, but it is masked by secondary hypogonadism. If you're willing, report your new...
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    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    A problem with having limited data is that you can come up with various hypotheses that are consistent with the results yet are vastly different. So here's an update on the examination of testosterone suspension: For a period I switched to an aqueous testosterone solution, as described above. I...
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    Hypo since 20 y/o - now 30. Thoughts on this bloodwork?

    I think you have the right idea: Retest testosterone, and also LH and FSH. Make sure it's done not too long after waking. Throw in SHBG if you're not also testing free testosterone via equilibrium dialysis. Estradiol should probably be in there too. Your 2021 results do hint at testicular...
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    Inject hCG IM for better results?

    The point is that if you open the door to anecdotal evidence then there are examples suggesting faster SC absorption in some cases. However, I have much more confidence in the controlled studies measuring AUCs. No, it takes >40° C to invoke non-negligible degradation. That's not happening...
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    Inject hCG IM for better results?

    It may be far-fetched, but less so than some mysterious and unelucidated mechanism of testosterone destruction.
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    Inject hCG IM for better results?

    If with both SC and IM you ensured you had no injection site leakage and you measured free testosterone at enough time points in an injection cycle to accurately estimate AUC then you'd have some grounds to claim reduced bioavailability. What I've been saying is that measuring testosterone at...
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    Inject hCG IM for better results?

    Fair enough, since there's little, if any, hard data. Anecdotal reports appear to favor it. Grok says this: Injection site leakage, where a small amount of the oil-based medication (such as testosterone enanthate or cypionate) seeps out from the puncture wound after needle withdrawal, appears...
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    Inject hCG IM for better results?

    Occam's razor. There's injection site leakage, a known phenomenon that's almost certainly going to be more prevalent with SC injections. Then there's some mysterious, never directly observed, testosterone-destroying interaction that disappears under controlled conditions—and worse, is assumed to...
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    Inject hCG IM for better results?

    Somehow you forgot about the Xyosted study. Meanwhile there are no controlled studies pointing to dissimilar bioavailability for SC and IM. I presume if I were trying to support an argument with anecdotes that did not even measure the parameter in question then you would jump on that. But now...
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    Inject hCG IM for better results?

    As long as we're fantasizing that someone's going to fund such a study then of course it should include enough samples to generate accurate AUCs. But first, if you're rejecting the explanation involving injection site leakage then you should come up with a remotely plausible alternative...
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    Inject hCG IM for better results?

    Have to re-emphasize: "Clinical data consistently shows that SC administration of testosterone esters achieves comparable bioavailability to IM." Under controlled conditions the bioavailability is the same. What you're left with are basically three things: • Localized side effects. Ok, some...
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    Inject hCG IM for better results?

    Query to Grok: Someone asserts that testosterone esters have less bioavailability when delivered subcutaneously (SC) versus intra-muscularly (IM). I disagree, pointing to Xyosted clinical trials that show similar areas-under-the-curves. He then points to a study showing that hCG does have less...
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    TRT in Canada if borderline Testosterone and Prolactin?

    If you stop there one might think that elevated prolactin equals more dopamine activity. Nope. Modestly high levels of prolactin can reduce dopamine activity in men. Prolactin and dopamine have an inverse relationship in the brain, primarily regulated through the hypothalamic-pituitary axis...
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    7.5mgs daily labs

    Let's keep this in perspective: The lab measurement error is probably around the same size as or greater than the daily variation you see in levels. It's not something to even think about unless you shift to less frequent injections.
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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