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      Article Preview Sleep - its role in maintaining men's health can not be overstated. Recently, at the American Urological Association Convention, three studies were presented that showed just how critical adequate sleep ...
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      Article Preview As part of prostate cancer (PCa) therapy, many men are deprived of all androgens. This "chemical castration" leads to profound hypogonadism and exceedingly low levels of estradiol. It also results ...
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      Article Preview It's been known for years that PDE5 inhibitors, Viagra, Cialis, Levitra, improve erectile function in men. However, a surprising number of men in a double-blind, controlled study of sildenafil (Viagra) ...
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      Article Preview The questions are regularly posed here at Excelmale: Will HCG help me maintain fertility while on a TRT protocol? How much HCG must I use to remain fertile? This case report answers some of those questions.

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      Article Preview It's a mouse study - the point is acknowledged. However, new research at MIT raises some intriguing issues.

      As people age, their intestinal stem cells begin to lose their ability to regenerate. These stem cells are the source for all new intestinal cells, so this decline can make it more difficult to recover from gastrointestinal infections or other conditions that affect the intestine. This age-related loss of stem cell function can be reversed by a 24-hour fast, according to a new study from MIT biologists. The researchers found that fasting dramatically improves stem cells’ ability to regenerate, in both aged and young mice.

      In fasting mice, cells begin breaking down fatty acids instead of glucose, a change that stimulates the stem cells to become more regenerative. The researchers found that they could also boost regeneration with a molecule that activates the same metabolic switch. Such an intervention could potentially help older people recovering from GI infections or cancer patients undergoing chemotherapy, the researchers say.
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      Article Preview
      • Currently, only topical minoxidil (MNX) and oral finasteride (FNS) are approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of androgenetic alopecia.
      • Although FNS is efficacious for hair regrowth, its systemic use is associated with side effects limiting long-term utilization. Exploring topical FNS as an alternative treatment regimen may prove promising.
      • In its systemic form, various side effects such as gynecomastia, breast tenderness, malignant neoplasms of the male breast, decreased ejaculate volume, a decrease in testicular size, testicular pain, reduction in penile curvature, reduction in penile size, sexual disorder, male infertility, high-grade prostate cancer, and prostatitis have been reported.
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      Article Preview One of the most frequent, unwanted side-effect for men on TRT is the rise in hematocrit levels. A recent study of trans men highlighted the issue.



      • In trans persons on gender-affirming hormonal treatment, a decrease (in trans women) or increase (in trans men) in hematocrit is often observed.
      • 625 hormone-naïve trans persons were enrolled in the study.
      • Gender-affirming hormonal treatment was initiated at the first visit.
      • In trans men, serum hematocrit (Hct) levels increased during the first year (+4.9 Hct %, 95% CI 3.82-5.25), with the most pronounced increase during the first 3 months (+2.7 Hct %, 95% CI 1.94-3.29).
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      Current infection with Helicobacter pylori (H. Pylori) was associated with significant subclinical coronary artery stenosis in a population with no prior arterial disease, suggesting a need for earlier diagnosis and treatment of this pathogen to forestall progression to overt disease, researchers reported.

      "This result suggests the possibility that H. pylori eradication might be worthwhile in preventing coronary artery disease, Shinae Kang, MD, PhD, of Yonsei University College of Medicine in Seoul, South Korea, and colleagues wrote online in PLoS One.


      • To address H. pylori's impact on the arteries of healthy individuals, Kang's group studied 463 consecutive patients who underwent voluntary health check-ups at Gangnam Severance Hospital in Seoul during 2007-2014. The mean age of participants was 54.2, and 336 were men.
      • The patients underwent post-biopsy rapid urease testing of gastric mucosa, using the Campylobacter-like organism test (CLO) and were then divided into two groups based on CLO status. Patients also underwent pulse-wave velocity (PWV) measurement and cardiac multidetector computed tomography.
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      Synthetic cannabinoids are designer drugs that differ in some significant ways from the natural cannabinoids found in cannabis plants. They are often marketed as designer drugs or sold in products with claims they give the same effect as cannabis.

      Synthetic cannabinoids (SCs) have been increasingly used all over the world, particularly among young‐adult population. SCs can cause severe adverse effects on several organ systems. However, there are no studies in the literature which have stated the possible relationship between using of SCs and priapism. We present a case of 28‐year‐old man who was diagnosed with a 58‐hr lasting priapism after regular administrations of SCs.

      • The priapism did not resolve either after applying aspiration with irrigation or shunt surgery.
      • Penile prosthesis implantation was performed as a last treatment option.
      • The SCs have been increasingly used among young population in recent years; therefore, new SC‐related ischaemic priapism cases might be encountered in the emergency departments


      "A new cause of ischaemic priapism: Synthetic cannabinoids," Andrologica, 1 April 2018, https://onlinelibrary.wiley.com/doi/...1111/and.13013
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      Adults with hypothyroidism prescribed levothyroxine were more likely to experience lower health-related quality of life and increased comorbidities when compared with similar adults not prescribed thyroid hormone therapy.


      • “Hypothyroidism is a common endocrine disorder, and substitution therapy with levothyroxine is the standard of care,” Hanneke Wouters of University Medical Center Groningen, Netherlands, said during an oral abstract presentation at the Endocrine Society Annual Meeting. “Unfortunately, about 10% of the individuals using this drug continue to experience symptoms and a disturbed wellbeing and a disturbed quality of life, despite the fact that their [thyroid-stimulating hormone] level is within the normal range, so they are euthyroid.”

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      Higher concentrations of arsenic and fluoride in the public drinking water supply in Newfoundland and Labrador may be associated with the high incidence of type 1 diabetes in the Canadian province, according to findings published in BMJ Open Diabetes Research & Care.

      • Newfoundland and Labrador has the second highest incidence rate of type 1 diabetes in the world after Finland, with an incidence rate of 49.9 per 100,000 for children during the 2007-2010 period. The highest incidence during 2007-2010 was among children aged 5 to 9 years, they noted, with an incidence rate ratio of 59.1 for that age group.
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      Adolescents who created real-world diets attempting to avoid exposure to bisphenol A, or BPA, for 7 days experienced no change in urinary BPA levels and reported difficulty in avoiding the endocrine-disrupting chemical, according to findings published in BMJ Open.


      • “Based on our evidence, it is extremely difficult to reduce one’s own exposure to BPA by actively trying to avoid known sources,” Lorna Harries, PhD, associate professor in molecular genetics at the College of Life and Environmental Sciences at the University of Exeter, United Kingdom, told Endocrine Today. “Our study indicates that the control over exposure to BPA currently does not lie with the consumer. At present, the ubiquitous nature of BPA in our environment and inadequacies in current labeling practices mean that it is very difficult to identify BPA-free foods.”



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    • You have probably reached our site in your search for health and potency. Are you wondering who to trust with men’s health information in an online world full of scammers and deception? Well, you are in the right place!

      Welcome to ExcelMale.com, one of the largest and best moderated men’s health forums on the Internet focused on increasing health, potency and productivity in men. With over 13,000 members (as of April 2016) that include educated men, physicians, pharmacists, dietitians, exercise trainers, nutritional supplement experts, and other professionals in the field, ExcelMale is fast becoming a leader in the field. Our forum topics range from testosterone replacement therapy, Trimix injections use for ED, HCG use for better fertility and libido, estradiol management, thyroid function optimization, peptide information, exercise routines, best supplements for men, high protein diets, testosterone side effect management and much more. We also provide men’s health information via Interviews with experts, Videos, and webinars. Last but not least, our members share their reviews of hormone replacement clinics and doctors, compounding pharmacies, pharmaceutical products, supplements, and much more. Our great moderators review every post daily to detect spammers or abuse, so ExcelMale is a safe environment for all men. And since every man wants to help important women in their lives, we do not neglect female health information as we include a folder called “ExcelFemale” to post the latest on HRT in women.


      Search our content by typing your question here.

      Register here to join our community! Don’t be shy, ask questions by posting in any forum folder. We can help each other to regain our best selves!.


      Wishing you the greatest health,

      Nelson Vergel

      Founder